Selenium treatment protects diabetes-induced biochemical and ultrastructural alterations in liver tissue

We have shown that a single dose of streptozotocin (STZ) (50 mg/kg body weight) injected into rats caused significant changes in some antioxidant enzyme activities, such as glutathione peroxidase, glutathione reductase, glutathione-S-transferase, glucose-6-phosphate dehydrogenase, and 6-phosphogluco...

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Veröffentlicht in:	Biological trace element research 2005-06, Vol.105 (1-3), p.135-150
Hauptverfasser:	Can, Belgin, Ulusu, N Nuray, Kilinç, Kamer, Leyla Acan, N, Saran, Yüksel, Turan, Belma
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Blood Glucose - metabolism Body Weight Cytoplasm - metabolism Dehydrogenase Diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Enzymatic activity Enzymes Glucosephosphate Dehydrogenase - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism Hepatocytes - metabolism Liver Liver - drug effects Liver - metabolism Liver - pathology Liver - ultrastructure Microscopy, Electron Mitochondria - metabolism Oxidative Stress Phosphogluconate Dehydrogenase - metabolism Polyribosomes - metabolism Rats Rats, Wistar Rodents Selenium Selenium - blood Selenium - metabolism Selenium - pharmacology Sodium Sodium Selenite - pharmacology Tissues
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