Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

Expression profiling of T24 cells revealed that 17 out of 313 human miRNAs were upregulated more than 3-fold by simultaneous treatment with the chromatin-modifying drugs 5-aza-2′-deoxycytidine and 4-phenylbutyric acid. One of these, miR-127, is embedded in a CpG island and is highly induced from its...

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Veröffentlicht in:	Cancer cell 2006-06, Vol.9 (6), p.435-443
Hauptverfasser:	Saito, Yoshimasa, Liang, Gangning, Egger, Gerda, Friedman, Jeffrey M., Chuang, Jody C., Coetzee, Gerhard A., Jones, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Azacitidine - analogs & derivatives Azacitidine - pharmacology Cell Line, Tumor CELLCYCLE Chromatin - metabolism CpG Islands DNA DNA Methylation - drug effects DNA-Binding Proteins - metabolism Down-Regulation Epigenesis, Genetic Histone Deacetylase Inhibitors Humans MicroRNAs - biosynthesis MicroRNAs - metabolism Phenylbutyrates - pharmacology Promoter Regions, Genetic Proto-Oncogene Proteins c-bcl-6 - metabolism RNA
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