Grape Seed Procyanidins Prevent Oxidative Injury by Modulating the Expression of Antioxidant Enzyme Systems

In the present paper, we report the effect of a grape seed procyanidin extract (GSPE) on antioxidant enzyme systems (AOEs). Gene expression was tested using the hepatocarcinoma cell line HepG2 by exposing it to several GSPE doses between 0 and 100 mg/L for 24 h. We evaluated mRNA expression and enzy...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2005-07, Vol.53 (15), p.6080-6086
Hauptverfasser:	Puiggròs, Francesc, Llópiz, Niurka, Ardévol, Anna, Bladé, Cinta, Arola, Lluís, Salvadó, M. Josepa
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line, Tumor Food industries Fruit and vegetable industries Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - drug effects Glutathione Peroxidase - genetics Glutathione Reductase - genetics Glutathione Transferase - genetics Hepatoblastoma Humans Liver Neoplasms Oxidative Stress - drug effects Proanthocyanidins - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Seeds - chemistry Superoxide Dismutase - genetics Vitis - chemistry
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