pH-Sensitive polymer blends used as coating materials to control drug release from spherical beads: elucidation of the underlying mass transport mechanisms

To elucidate the drug release mechanisms from pellets coated with pH-sensitive polymer blends. Verapamil hydrochloride-loaded beads were coated with various blends of a water-insoluble and an enteric polymer, ethylcellulose:Eudragit L and Eudragit NE:Eudragit L, respectively. Both experimental and t...

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Veröffentlicht in:	Pharmaceutical research 2005-07, Vol.22 (7), p.1129-1141
Hauptverfasser:	Lecomte, Florence, Siepmann, Juergen, Walther, Mathias, MacRae, Ross J, Bodmeier, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Cellulose - analogs & derivatives Cellulose - chemistry Delayed-Action Preparations - chemistry Drug Compounding Drug delivery systems Drug dosages Hydrogen-Ion Concentration Methacrylates - chemistry Microscopy, Electron, Scanning Permeability Pharmacy Polymer blends Polymers - chemistry Protective coatings Solubility Time Factors Verapamil - administration & dosage Verapamil - chemistry Water - analysis Water - chemistry
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