A Polymorphism in Plasma Platelet-activating Factor Acetylhydrolase is Involved in Resistance to Immunoglobulin Treatment in Kawasaki Disease

To investigate whether reduced levels of plasma platelet-activating factor acetylhydrolase (PAF-AH) as a result of a genetic polymorphism are involved in the pathogenesis of Kawasaki disease (KD). The frequency of a V279F polymorphism (G/T transversion) in the PAF-AH gene was quantified in 76 Japane...

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Veröffentlicht in:	The Journal of pediatrics 2005-07, Vol.147 (1), p.78-83
Hauptverfasser:	Minami, Takaomi, Suzuki, Hiroyuki, Takeuchi, Takashi, Uemura, Shigeru, Sugatani, Junko, Yoshikawa, Norishige
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics Biological and medical sciences Case-Control Studies Child Child, Preschool Drug Resistance - genetics Female General aspects Humans Immunoglobulins, Intravenous - pharmacology Infant Japan - epidemiology Male Medical sciences Mucocutaneous Lymph Node Syndrome - drug therapy Mucocutaneous Lymph Node Syndrome - epidemiology Mucocutaneous Lymph Node Syndrome - genetics Polymorphism, Genetic Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Statistics, Nonparametric
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