GMF-knockout mice are unable to induce brain-derived neurotrophic factor after exercise
We earlier reported that overexpression of glia maturation factor (GMF) in cultured astrocytes enhances the production of brain-derived neurotrophic factor (BDNF). The current study was conducted to find out whether BDNF production is impaired in animals devoid of GMF. To this end GMF-knockout (KO)...
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| Veröffentlicht in: | Neurochemical research 2006-04, Vol.31 (4), p.579-584 |
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| container_title | Neurochemical research |
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| creator | Zaheer, Asgar Haas, Joel T Reyes, Carlos Mathur, Satya N Yang, Baoli Lim, Ramon |
| description | We earlier reported that overexpression of glia maturation factor (GMF) in cultured astrocytes enhances the production of brain-derived neurotrophic factor (BDNF). The current study was conducted to find out whether BDNF production is impaired in animals devoid of GMF. To this end GMF-knockout (KO) mice were subjected to exercise and the neurotrophin mRNAs were determined by real-time RT-PCR. Compared to wild-type (WT) mice, there is a decrease in exercise-induced BDNF in the KO mice. The observation was correlated with the finding that, in WT mice, exercise increases GMF expression. The results are consistent with the hypothesis that GMF is necessary for exercise-induction of BDNF, and that GMF may promote neuroprotection through BDNF production. |
| doi_str_mv | 10.1007/s11064-006-9049-3 |
| format | Article |
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The current study was conducted to find out whether BDNF production is impaired in animals devoid of GMF. To this end GMF-knockout (KO) mice were subjected to exercise and the neurotrophin mRNAs were determined by real-time RT-PCR. Compared to wild-type (WT) mice, there is a decrease in exercise-induced BDNF in the KO mice. The observation was correlated with the finding that, in WT mice, exercise increases GMF expression. The results are consistent with the hypothesis that GMF is necessary for exercise-induction of BDNF, and that GMF may promote neuroprotection through BDNF production.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-006-9049-3</identifier><identifier>PMID: 16758368</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Female ; Glia Maturation Factor - genetics ; Glia Maturation Factor - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Growth Factor - genetics ; Nerve Growth Factor - metabolism ; Neuroprotective Agents - metabolism ; Neurotrophin 3 - genetics ; Neurotrophin 3 - metabolism ; Physical Conditioning, Animal ; RNA, Messenger - metabolism</subject><ispartof>Neurochemical research, 2006-04, Vol.31 (4), p.579-584</ispartof><rights>Springer Science+Business Media, Inc. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-109361aa832f1f7fe72387d03043c5010d4b408a584bfccb8e56d431f77d23893</citedby><cites>FETCH-LOGICAL-c357t-109361aa832f1f7fe72387d03043c5010d4b408a584bfccb8e56d431f77d23893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16758368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaheer, Asgar</creatorcontrib><creatorcontrib>Haas, Joel T</creatorcontrib><creatorcontrib>Reyes, Carlos</creatorcontrib><creatorcontrib>Mathur, Satya N</creatorcontrib><creatorcontrib>Yang, Baoli</creatorcontrib><creatorcontrib>Lim, Ramon</creatorcontrib><title>GMF-knockout mice are unable to induce brain-derived neurotrophic factor after exercise</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>We earlier reported that overexpression of glia maturation factor (GMF) in cultured astrocytes enhances the production of brain-derived neurotrophic factor (BDNF). 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| subjects | Animals Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Female Glia Maturation Factor - genetics Glia Maturation Factor - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Neuroprotective Agents - metabolism Neurotrophin 3 - genetics Neurotrophin 3 - metabolism Physical Conditioning, Animal RNA, Messenger - metabolism |
| title | GMF-knockout mice are unable to induce brain-derived neurotrophic factor after exercise |
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