Protein misfolding, functional amyloid, and human disease

Peptides or proteins convert under some conditions from their soluble forms into highly ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging from neurodegenerative disorders to systemic amyloidoses. In this review, we identify the diseases known to be assoc...

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Veröffentlicht in:	Annual review of biochemistry 2006-01, Vol.75 (1), p.333-366
Hauptverfasser:	Chiti, Fabrizio, Dobson, Christopher M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Amino Acid Sequence Amyloid - chemistry Amyloid - genetics Amyloid - metabolism Amyloidosis - metabolism Amyloidosis - pathology Amyloidosis - physiopathology Biodiversity Humans Models, Molecular Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - physiopathology Neurological disorders Pathology Peptides Polymorphism, Genetic Protein Conformation Protein Folding Proteins
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