Antihypoxic and antinecrotic effect of mexidol in skin ischemia
Course treatment with mexidol in a dose of 25 mg/kg for 3 days decreased activities of aspartate transaminase and creatine phosphokinase in the plasma on day 3 after the incidence of skin ischemia (by 1.3 and 1.66 times, respectively). Under these conditions the index of cytolysis decreased by 1.3 t...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2005-02, Vol.139 (2), p.202-206 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 139 |
| creator | Galenko-Yaroshevskii, V P Bagmetova, E N Fil'chukova, I A Sidel'nikov, A Yu Popkov, V A Gorelashvili, A S Antelava, N A Sukoyan, G V |
| description | Course treatment with mexidol in a dose of 25 mg/kg for 3 days decreased activities of aspartate transaminase and creatine phosphokinase in the plasma on day 3 after the incidence of skin ischemia (by 1.3 and 1.66 times, respectively). Under these conditions the index of cytolysis decreased by 1.3 times. Therefore, mexidol prevented progression of necrotic processes in the skin. Mexidol therapy of animals with skin ischemia restored the reserve capacity of systems for energy supply and antioxidant defense. The systems of NADH-ubiquinone reductase and succinate-ubiquinone reductase served as the targets for the action of mexidol. Mexidol significantly decreased the damaging effect of reactive oxygen species. Dermatoprotective properties of mexidol were associated with its influence on the energy supply system (regulation of enzyme activity in the electron transport chain, ubiquinone metabolism) and antioxidant defense. |
| doi_str_mv | 10.1007/s10517-005-0248-8 |
| format | Article |
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| subjects | Animals Antioxidants - pharmacology Antioxidants - therapeutic use Cell Hypoxia - drug effects Electron Transport Complex I - metabolism Electron Transport Complex II - metabolism Ischemia - drug therapy Ischemia - enzymology Necrosis - drug therapy Picolines - pharmacology Picolines - therapeutic use Rats Skin - blood supply Skin - pathology |
| title | Antihypoxic and antinecrotic effect of mexidol in skin ischemia |
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