SzA mutations of the B subunit of the Drosophila vacuolar H⁺ ATPase identify conserved residues essential for function in fly and yeast

V-ATPases play multiple roles in eukaryotes: in Drosophila, null mutations are recessive lethal. Here, mutations underlying five extant lethal alleles of vha55, encoding the B subunit, were identified, including a premature termination codon and two mutations very close to residues thought to partic...

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