Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma
Little is known about the Bcl-2 family members in mesothelioma. These proteins are involved in the control of apoptosis, carrying out both pro- and anti- apoptotic functions. Immunohistochemistry was used to examine the expression of p53 and Bcl-2 family members in 54 archival mesothelioma samples (...
Gespeichert in:
| Veröffentlicht in: | Acta oncologica 2006, Vol.45 (4), p.449-453 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 453 |
|---|---|
| container_issue | 4 |
| container_start_page | 449 |
| container_title | Acta oncologica |
| container_volume | 45 |
| creator | O'Kane, Sara L. Pound, Rachelle J. Campbell, Anne Chaudhuri, Nilanjan Lind, Michael J. Cawkwell, Lynn |
| description | Little is known about the Bcl-2 family members in mesothelioma. These proteins are involved in the control of apoptosis, carrying out both pro- and anti- apoptotic functions. Immunohistochemistry was used to examine the expression of p53 and Bcl-2 family members in 54 archival mesothelioma samples (39 epithelial, 15 sarcomatoid tumours). Overexpression of p53 was observed in 81% (44/54). For anti-apoptotic proteins, overexpression was recorded as follows: Bcl-2 40% (22/54), Bcl-XL 24% (13/54), Mcl-1 92% (50/54). For pro-apoptotic proteins, loss of expression was recorded as follows: Bad 25% (14/54), Bak 24% (13/54), Bax 42% (23/54), Bid 37% (20/54), Bim 18% (10/54). Statistically significant differences between epithelial and sarcomatoid tumours were observed for Bid (p < 0.001), Bad (p = 0.012) and Bcl-XL (p = 0.03). Significant differences in abnormal expression of apoptosis proteins were found between epithelial and sarcomatoid subtypes but histological subtype was the only factor with significant association to patient prognosis. |
| doi_str_mv | 10.1080/02841860500468927 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68051546</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68051546</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-1ab6785ac3c1c0efdf00d4179f9d504e98998231fef2e636347f443c818301cd3</originalsourceid><addsrcrecordid>eNp9kE1Lw0AURQdRbK3-ADeSlbvoe_mYTHCltVWhRRcK3YXp5I1NmWTqTAL235vSggvB1Vuccy-8y9glwg2CgFuIRIKCQwqQcJFH2REbIk8xjCK-OGbDHQ97YTFgZ96vASCKs_SUDZBnHFDgkD1OvjeOvK9sE1gdPCgTRsFU1pXZBnOql-R8UDXBXJrqs5FNG7wZ6pw0PfS2XZGpbC3P2YmWxtPF4Y7Yx3TyPn4OZ69PL-P7WagSzNoQ5ZJnIpUqVqiAdKkByp7kOi9TSCgXeS6iGDXpiHjM4yTTSRIrgSIGVGU8Ytf73o2zXx35tqgrr8gY2ZDtfMEFpJgmvBdxLypnvXeki42raum2BUKxm674M12fuTqUd8uayt_EYateuNsLVaOtq-WKpGlXSjoq1rZzTf_5P_U_Cul6PQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68051546</pqid></control><display><type>article</type><title>Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma</title><source>MEDLINE</source><source>Taylor & Francis Journals Complete</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>O'Kane, Sara L. ; Pound, Rachelle J. ; Campbell, Anne ; Chaudhuri, Nilanjan ; Lind, Michael J. ; Cawkwell, Lynn</creator><creatorcontrib>O'Kane, Sara L. ; Pound, Rachelle J. ; Campbell, Anne ; Chaudhuri, Nilanjan ; Lind, Michael J. ; Cawkwell, Lynn</creatorcontrib><description>Little is known about the Bcl-2 family members in mesothelioma. These proteins are involved in the control of apoptosis, carrying out both pro- and anti- apoptotic functions. Immunohistochemistry was used to examine the expression of p53 and Bcl-2 family members in 54 archival mesothelioma samples (39 epithelial, 15 sarcomatoid tumours). Overexpression of p53 was observed in 81% (44/54). For anti-apoptotic proteins, overexpression was recorded as follows: Bcl-2 40% (22/54), Bcl-XL 24% (13/54), Mcl-1 92% (50/54). For pro-apoptotic proteins, loss of expression was recorded as follows: Bad 25% (14/54), Bak 24% (13/54), Bax 42% (23/54), Bid 37% (20/54), Bim 18% (10/54). Statistically significant differences between epithelial and sarcomatoid tumours were observed for Bid (p < 0.001), Bad (p = 0.012) and Bcl-XL (p = 0.03). Significant differences in abnormal expression of apoptosis proteins were found between epithelial and sarcomatoid subtypes but histological subtype was the only factor with significant association to patient prognosis.</description><identifier>ISSN: 0284-186X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.1080/02841860500468927</identifier><identifier>PMID: 16760181</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Aged ; Apoptosis ; bcl-2 Homologous Antagonist-Killer Protein - metabolism ; bcl-2-Associated X Protein - metabolism ; bcl-X Protein - metabolism ; BH3 Interacting Domain Death Agonist Protein - metabolism ; Female ; Humans ; Male ; Mesothelioma - metabolism ; Mesothelioma - pathology ; Middle Aged ; Neoplasms, Glandular and Epithelial - metabolism ; Neoplasms, Glandular and Epithelial - pathology ; Pleural Neoplasms - metabolism ; Pleural Neoplasms - pathology ; Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><ispartof>Acta oncologica, 2006, Vol.45 (4), p.449-453</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-1ab6785ac3c1c0efdf00d4179f9d504e98998231fef2e636347f443c818301cd3</citedby><cites>FETCH-LOGICAL-c417t-1ab6785ac3c1c0efdf00d4179f9d504e98998231fef2e636347f443c818301cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/02841860500468927$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/02841860500468927$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4014,27914,27915,27916,61210,61391</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16760181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Kane, Sara L.</creatorcontrib><creatorcontrib>Pound, Rachelle J.</creatorcontrib><creatorcontrib>Campbell, Anne</creatorcontrib><creatorcontrib>Chaudhuri, Nilanjan</creatorcontrib><creatorcontrib>Lind, Michael J.</creatorcontrib><creatorcontrib>Cawkwell, Lynn</creatorcontrib><title>Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Little is known about the Bcl-2 family members in mesothelioma. These proteins are involved in the control of apoptosis, carrying out both pro- and anti- apoptotic functions. Immunohistochemistry was used to examine the expression of p53 and Bcl-2 family members in 54 archival mesothelioma samples (39 epithelial, 15 sarcomatoid tumours). Overexpression of p53 was observed in 81% (44/54). For anti-apoptotic proteins, overexpression was recorded as follows: Bcl-2 40% (22/54), Bcl-XL 24% (13/54), Mcl-1 92% (50/54). For pro-apoptotic proteins, loss of expression was recorded as follows: Bad 25% (14/54), Bak 24% (13/54), Bax 42% (23/54), Bid 37% (20/54), Bim 18% (10/54). Statistically significant differences between epithelial and sarcomatoid tumours were observed for Bid (p < 0.001), Bad (p = 0.012) and Bcl-XL (p = 0.03). Significant differences in abnormal expression of apoptosis proteins were found between epithelial and sarcomatoid subtypes but histological subtype was the only factor with significant association to patient prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Apoptosis</subject><subject>bcl-2 Homologous Antagonist-Killer Protein - metabolism</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>bcl-X Protein - metabolism</subject><subject>BH3 Interacting Domain Death Agonist Protein - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mesothelioma - metabolism</subject><subject>Mesothelioma - pathology</subject><subject>Middle Aged</subject><subject>Neoplasms, Glandular and Epithelial - metabolism</subject><subject>Neoplasms, Glandular and Epithelial - pathology</subject><subject>Pleural Neoplasms - metabolism</subject><subject>Pleural Neoplasms - pathology</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AURQdRbK3-ADeSlbvoe_mYTHCltVWhRRcK3YXp5I1NmWTqTAL235vSggvB1Vuccy-8y9glwg2CgFuIRIKCQwqQcJFH2REbIk8xjCK-OGbDHQ97YTFgZ96vASCKs_SUDZBnHFDgkD1OvjeOvK9sE1gdPCgTRsFU1pXZBnOql-R8UDXBXJrqs5FNG7wZ6pw0PfS2XZGpbC3P2YmWxtPF4Y7Yx3TyPn4OZ69PL-P7WagSzNoQ5ZJnIpUqVqiAdKkByp7kOi9TSCgXeS6iGDXpiHjM4yTTSRIrgSIGVGU8Ytf73o2zXx35tqgrr8gY2ZDtfMEFpJgmvBdxLypnvXeki42raum2BUKxm674M12fuTqUd8uayt_EYateuNsLVaOtq-WKpGlXSjoq1rZzTf_5P_U_Cul6PQ</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>O'Kane, Sara L.</creator><creator>Pound, Rachelle J.</creator><creator>Campbell, Anne</creator><creator>Chaudhuri, Nilanjan</creator><creator>Lind, Michael J.</creator><creator>Cawkwell, Lynn</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma</title><author>O'Kane, Sara L. ; Pound, Rachelle J. ; Campbell, Anne ; Chaudhuri, Nilanjan ; Lind, Michael J. ; Cawkwell, Lynn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1ab6785ac3c1c0efdf00d4179f9d504e98998231fef2e636347f443c818301cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apoptosis</topic><topic>bcl-2 Homologous Antagonist-Killer Protein - metabolism</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>bcl-X Protein - metabolism</topic><topic>BH3 Interacting Domain Death Agonist Protein - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mesothelioma - metabolism</topic><topic>Mesothelioma - pathology</topic><topic>Middle Aged</topic><topic>Neoplasms, Glandular and Epithelial - metabolism</topic><topic>Neoplasms, Glandular and Epithelial - pathology</topic><topic>Pleural Neoplasms - metabolism</topic><topic>Pleural Neoplasms - pathology</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Kane, Sara L.</creatorcontrib><creatorcontrib>Pound, Rachelle J.</creatorcontrib><creatorcontrib>Campbell, Anne</creatorcontrib><creatorcontrib>Chaudhuri, Nilanjan</creatorcontrib><creatorcontrib>Lind, Michael J.</creatorcontrib><creatorcontrib>Cawkwell, Lynn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Kane, Sara L.</au><au>Pound, Rachelle J.</au><au>Campbell, Anne</au><au>Chaudhuri, Nilanjan</au><au>Lind, Michael J.</au><au>Cawkwell, Lynn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>2006</date><risdate>2006</risdate><volume>45</volume><issue>4</issue><spage>449</spage><epage>453</epage><pages>449-453</pages><issn>0284-186X</issn><eissn>1651-226X</eissn><abstract>Little is known about the Bcl-2 family members in mesothelioma. These proteins are involved in the control of apoptosis, carrying out both pro- and anti- apoptotic functions. Immunohistochemistry was used to examine the expression of p53 and Bcl-2 family members in 54 archival mesothelioma samples (39 epithelial, 15 sarcomatoid tumours). Overexpression of p53 was observed in 81% (44/54). For anti-apoptotic proteins, overexpression was recorded as follows: Bcl-2 40% (22/54), Bcl-XL 24% (13/54), Mcl-1 92% (50/54). For pro-apoptotic proteins, loss of expression was recorded as follows: Bad 25% (14/54), Bak 24% (13/54), Bax 42% (23/54), Bid 37% (20/54), Bim 18% (10/54). Statistically significant differences between epithelial and sarcomatoid tumours were observed for Bid (p < 0.001), Bad (p = 0.012) and Bcl-XL (p = 0.03). Significant differences in abnormal expression of apoptosis proteins were found between epithelial and sarcomatoid subtypes but histological subtype was the only factor with significant association to patient prognosis.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16760181</pmid><doi>10.1080/02841860500468927</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0284-186X |
| ispartof | Acta oncologica, 2006, Vol.45 (4), p.449-453 |
| issn | 0284-186X 1651-226X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68051546 |
| source | MEDLINE; Taylor & Francis Journals Complete; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Aged Apoptosis bcl-2 Homologous Antagonist-Killer Protein - metabolism bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism BH3 Interacting Domain Death Agonist Protein - metabolism Female Humans Male Mesothelioma - metabolism Mesothelioma - pathology Middle Aged Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Pleural Neoplasms - metabolism Pleural Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism |
| title | Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T18%3A41%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20Bcl-2%20Family%20Members%20in%20Malignant%20Pleural%20Mesothelioma&rft.jtitle=Acta%20oncologica&rft.au=O'Kane,%20Sara%20L.&rft.date=2006&rft.volume=45&rft.issue=4&rft.spage=449&rft.epage=453&rft.pages=449-453&rft.issn=0284-186X&rft.eissn=1651-226X&rft_id=info:doi/10.1080/02841860500468927&rft_dat=%3Cproquest_cross%3E68051546%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68051546&rft_id=info:pmid/16760181&rfr_iscdi=true |