Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments
Trisomy 21 or Down syndrome (DS) is a complex syndrome, of genetic origin with multiple and variable neurobiological and neuropsychological manifestations. DS patients have consistent signs of brain damage along their lives, but understanding the biology of DS is complicated due to the extraordinary...
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| Veröffentlicht in: | Behavior genetics 2006-05, Vol.36 (3), p.454-468 |
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| creator | Dierssen, Mara Ortiz-Abalia, Jon Arqué, Glòria de Lagrán, María Martínez Fillat, Cristina |
| description | Trisomy 21 or Down syndrome (DS) is a complex syndrome, of genetic origin with multiple and variable neurobiological and neuropsychological manifestations. DS patients have consistent signs of brain damage along their lives, but understanding the biology of DS is complicated due to the extraordinary heterogeneity of the phenotypic signs. Thus, treatment of DS mental retardation poses significant challenges for clinicians and scientists. The review addresses the classical pharmacological and environmental treatments and also critically reviews the new possibilities that are emerging from the exciting advances in gene or cell therapy. We describe some of the most recent developments in the field and give a sense of the prospects for future prevention and therapy. |
| doi_str_mv | 10.1007/s10519-006-9050-2 |
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DS patients have consistent signs of brain damage along their lives, but understanding the biology of DS is complicated due to the extraordinary heterogeneity of the phenotypic signs. Thus, treatment of DS mental retardation poses significant challenges for clinicians and scientists. The review addresses the classical pharmacological and environmental treatments and also critically reviews the new possibilities that are emerging from the exciting advances in gene or cell therapy. 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DS patients have consistent signs of brain damage along their lives, but understanding the biology of DS is complicated due to the extraordinary heterogeneity of the phenotypic signs. Thus, treatment of DS mental retardation poses significant challenges for clinicians and scientists. The review addresses the classical pharmacological and environmental treatments and also critically reviews the new possibilities that are emerging from the exciting advances in gene or cell therapy. We describe some of the most recent developments in the field and give a sense of the prospects for future prevention and therapy.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>16520905</pmid><doi>10.1007/s10519-006-9050-2</doi><tpages>15</tpages></addata></record> |
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| subjects | Adults Aggressiveness Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biology Biomedical research Brain - pathology Brain damage Brain injury Brain research Cell therapy Cognitive therapy Disease Models, Animal Down syndrome Down Syndrome - drug therapy Down Syndrome - genetics Down Syndrome - therapy Down's syndrome Downs syndrome Evidence based research Evidence-based medicine Evidence-Based Medicine - methods Evidence-Based Medicine - trends Genes Humans Infant Intellectual disabilities Mice N-Methylaspartate - physiology Newborn babies Phenotype Prospects Research parks Therapeutic approaches Treatment methods Trisomy Trisomy 21 |
| title | Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments |
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