Evaluation of the Effects of Ischemic Injury and Ureteral Obstruction on Delayed Graft Function in Cats After Renal Autotransplantation
To determine the relative importance of ischemic injury to delayed graft function (DGF) in cats. Experimental study. Six intact female cats. Cats had renal autograft transplantation without ureteral transection and reimplantation and a contralateral nephrectomy. Serum creatinine and blood urea nitro...
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| Veröffentlicht in: | Veterinary surgery 2006-06, Vol.35 (4), p.341-346 |
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| creator | MEHL, MARGO L KYLES, ANDREW E REIMER, S. BRENT FLYNN, ALISON K POLLARD, RACHEL E NYLAND, TOM KASS, PHILIP H GRIFFEY, STEPHEN M GREGORY, CLARE R |
| description | To determine the relative importance of ischemic injury to delayed graft function (DGF) in cats. Experimental study. Six intact female cats. Cats had renal autograft transplantation without ureteral transection and reimplantation and a contralateral nephrectomy. Serum creatinine and blood urea nitrogen (BUN) concentrations were measured regularly and abdominal ultrasound was performed before surgery, the day after surgery and twice weekly thereafter. Ultrasound-guided renal biopsy was performed on day 7. Cats were euthanatized on day 21. Histology of the autograft, ureter, bladder, vascular anastomoses sites, and contralateral kidney were performed. Observations were compared with those from an historic group of research cats that had extravesicular ureteroneocystostomy and contralateral nephrectomy. ¹ Five cats completed the study. Serum creatinine and BUN concentrations increased after surgery, peaking at 3.2±0.8 and 77.6±15.9 mg/dL, respectively, 1-2 days after surgery. Serum creatinine concentration returned to the reference interval by 6 days after surgery. BUN gradually decreased in all cats but did not return to the reference interval by study end. Serum creatinine and BUN concentrations were consistently lower but not significantly so (P=.29 and .56, respectively) compared with the historic ureteroneocystostomy group. No ultrasonographic abnormalities or renal biopsy histologic abnormalities were observed. At necropsy, 1 autograft had generalized interstitial fibrosis. Harvesting the renal graft and the ischemia before revascularization causes impaired renal function after engraftment. The process of harvesting and reimplanting the renal graft can contribute to DGF in cats, independent of ureteral obstruction. |
| doi_str_mv | 10.1111/j.1532-950X.2006.00155.x |
| format | Article |
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BRENT ; FLYNN, ALISON K ; POLLARD, RACHEL E ; NYLAND, TOM ; KASS, PHILIP H ; GRIFFEY, STEPHEN M ; GREGORY, CLARE R</creator><creatorcontrib>MEHL, MARGO L ; KYLES, ANDREW E ; REIMER, S. BRENT ; FLYNN, ALISON K ; POLLARD, RACHEL E ; NYLAND, TOM ; KASS, PHILIP H ; GRIFFEY, STEPHEN M ; GREGORY, CLARE R</creatorcontrib><description>To determine the relative importance of ischemic injury to delayed graft function (DGF) in cats. Experimental study. Six intact female cats. Cats had renal autograft transplantation without ureteral transection and reimplantation and a contralateral nephrectomy. Serum creatinine and blood urea nitrogen (BUN) concentrations were measured regularly and abdominal ultrasound was performed before surgery, the day after surgery and twice weekly thereafter. Ultrasound-guided renal biopsy was performed on day 7. Cats were euthanatized on day 21. Histology of the autograft, ureter, bladder, vascular anastomoses sites, and contralateral kidney were performed. Observations were compared with those from an historic group of research cats that had extravesicular ureteroneocystostomy and contralateral nephrectomy. ¹ Five cats completed the study. Serum creatinine and BUN concentrations increased after surgery, peaking at 3.2±0.8 and 77.6±15.9 mg/dL, respectively, 1-2 days after surgery. Serum creatinine concentration returned to the reference interval by 6 days after surgery. BUN gradually decreased in all cats but did not return to the reference interval by study end. Serum creatinine and BUN concentrations were consistently lower but not significantly so (P=.29 and .56, respectively) compared with the historic ureteroneocystostomy group. No ultrasonographic abnormalities or renal biopsy histologic abnormalities were observed. At necropsy, 1 autograft had generalized interstitial fibrosis. Harvesting the renal graft and the ischemia before revascularization causes impaired renal function after engraftment. The process of harvesting and reimplanting the renal graft can contribute to DGF in cats, independent of ureteral obstruction.</description><identifier>ISSN: 0161-3499</identifier><identifier>EISSN: 1532-950X</identifier><identifier>DOI: 10.1111/j.1532-950X.2006.00155.x</identifier><identifier>PMID: 16756614</identifier><language>eng</language><publisher>Malden, USA: Malden, USA : Blackwell Publishing Inc</publisher><subject>Animals ; Blood Urea Nitrogen ; Cat Diseases - blood ; Cat Diseases - diagnostic imaging ; Cat Diseases - pathology ; Cat Diseases - surgery ; Cats ; Creatinine - blood ; Delayed Graft Function - veterinary ; Female ; graft rejection ; Injuries ; ischemia ; Ischemia - veterinary ; Kidney - blood supply ; Kidney - diagnostic imaging ; kidney transplant ; Kidney Transplantation - methods ; Kidney Transplantation - veterinary ; Kidneys ; physiological response ; postoperative complications ; Postoperative Complications - veterinary ; renal function ; Skin & tissue grafts ; surgical transplantation ; tissue repair ; Transplants & implants ; Ultrasonography ; uremia ; ureter ; Ureteral Obstruction - veterinary ; urinary tract ; Urogenital system ; Veterinary services</subject><ispartof>Veterinary surgery, 2006-06, Vol.35 (4), p.341-346</ispartof><rights>Copyright 2006 by The American College of Veterinary Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4575-a5cccf7c85b027f722332d57f45318a4c6372d6b301ab7a608e4c7609cc570cb3</citedby><cites>FETCH-LOGICAL-c4575-a5cccf7c85b027f722332d57f45318a4c6372d6b301ab7a608e4c7609cc570cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-950X.2006.00155.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-950X.2006.00155.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16756614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MEHL, MARGO L</creatorcontrib><creatorcontrib>KYLES, ANDREW E</creatorcontrib><creatorcontrib>REIMER, S. BRENT</creatorcontrib><creatorcontrib>FLYNN, ALISON K</creatorcontrib><creatorcontrib>POLLARD, RACHEL E</creatorcontrib><creatorcontrib>NYLAND, TOM</creatorcontrib><creatorcontrib>KASS, PHILIP H</creatorcontrib><creatorcontrib>GRIFFEY, STEPHEN M</creatorcontrib><creatorcontrib>GREGORY, CLARE R</creatorcontrib><title>Evaluation of the Effects of Ischemic Injury and Ureteral Obstruction on Delayed Graft Function in Cats After Renal Autotransplantation</title><title>Veterinary surgery</title><addtitle>Vet Surg</addtitle><description>To determine the relative importance of ischemic injury to delayed graft function (DGF) in cats. Experimental study. Six intact female cats. Cats had renal autograft transplantation without ureteral transection and reimplantation and a contralateral nephrectomy. Serum creatinine and blood urea nitrogen (BUN) concentrations were measured regularly and abdominal ultrasound was performed before surgery, the day after surgery and twice weekly thereafter. Ultrasound-guided renal biopsy was performed on day 7. Cats were euthanatized on day 21. Histology of the autograft, ureter, bladder, vascular anastomoses sites, and contralateral kidney were performed. Observations were compared with those from an historic group of research cats that had extravesicular ureteroneocystostomy and contralateral nephrectomy. ¹ Five cats completed the study. Serum creatinine and BUN concentrations increased after surgery, peaking at 3.2±0.8 and 77.6±15.9 mg/dL, respectively, 1-2 days after surgery. Serum creatinine concentration returned to the reference interval by 6 days after surgery. BUN gradually decreased in all cats but did not return to the reference interval by study end. Serum creatinine and BUN concentrations were consistently lower but not significantly so (P=.29 and .56, respectively) compared with the historic ureteroneocystostomy group. No ultrasonographic abnormalities or renal biopsy histologic abnormalities were observed. At necropsy, 1 autograft had generalized interstitial fibrosis. Harvesting the renal graft and the ischemia before revascularization causes impaired renal function after engraftment. The process of harvesting and reimplanting the renal graft can contribute to DGF in cats, independent of ureteral obstruction.</description><subject>Animals</subject><subject>Blood Urea Nitrogen</subject><subject>Cat Diseases - blood</subject><subject>Cat Diseases - diagnostic imaging</subject><subject>Cat Diseases - pathology</subject><subject>Cat Diseases - surgery</subject><subject>Cats</subject><subject>Creatinine - blood</subject><subject>Delayed Graft Function - veterinary</subject><subject>Female</subject><subject>graft rejection</subject><subject>Injuries</subject><subject>ischemia</subject><subject>Ischemia - veterinary</subject><subject>Kidney - blood supply</subject><subject>Kidney - diagnostic imaging</subject><subject>kidney transplant</subject><subject>Kidney Transplantation - methods</subject><subject>Kidney Transplantation - veterinary</subject><subject>Kidneys</subject><subject>physiological response</subject><subject>postoperative complications</subject><subject>Postoperative Complications - veterinary</subject><subject>renal function</subject><subject>Skin & tissue grafts</subject><subject>surgical transplantation</subject><subject>tissue repair</subject><subject>Transplants & implants</subject><subject>Ultrasonography</subject><subject>uremia</subject><subject>ureter</subject><subject>Ureteral Obstruction - veterinary</subject><subject>urinary tract</subject><subject>Urogenital system</subject><subject>Veterinary services</subject><issn>0161-3499</issn><issn>1532-950X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd9u0zAUxi0EYmXwCmBxwV2C_8R2coNUStdVmpjEKOzOchybJaRJsR3WPsFeG6ephsQVvrGPzu_7zpE_ACBGKY7nfZNiRklSMHSbEoR4ihBmLN0_AbPHxlMwQ5jjhGZFcQZeeN8ghIoso8_BGeaCcY6zGXhY_lbtoELdd7C3MNwZuLTW6ODHcu31ndnWGq67ZnAHqLoKbpwJxqkWXpc-uEFP0g5-Mq06mAqunLIBXgzd1Kk7uFDRbW6jCn4xXVTOh9AHpzq_a1UXjsNfgmdWtd68Ot3nYHOx_Lq4TK6uV-vF_CrRGRMsUUxrbYXOWYmIsIIQSknFhM0YxbnKNKeCVLykCKtSKI5yk2nBUaE1E0iX9By8m3x3rv81GB_ktvbatHER0w9e8hwxlDMewbf_gE0_uLi9lwQzjjE9QvkEadd774yVO1dvlTtIjOSYlGzkGIgcA5FjUvKYlNxH6euT_1BuTfVXeIomAh8m4L5uzeG_jeW3m83xGQ2SyaD2wewfDZT7Kbmggsnvn1fyUnwkeHEr5DjwzcRb1Uv1w9Vebm4IwvEvUY6znNM_PYe7GA</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>MEHL, MARGO L</creator><creator>KYLES, ANDREW E</creator><creator>REIMER, S. BRENT</creator><creator>FLYNN, ALISON K</creator><creator>POLLARD, RACHEL E</creator><creator>NYLAND, TOM</creator><creator>KASS, PHILIP H</creator><creator>GRIFFEY, STEPHEN M</creator><creator>GREGORY, CLARE R</creator><general>Malden, USA : Blackwell Publishing Inc</general><general>Blackwell Publishing Inc</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200606</creationdate><title>Evaluation of the Effects of Ischemic Injury and Ureteral Obstruction on Delayed Graft Function in Cats After Renal Autotransplantation</title><author>MEHL, MARGO L ; KYLES, ANDREW E ; REIMER, S. BRENT ; FLYNN, ALISON K ; POLLARD, RACHEL E ; NYLAND, TOM ; KASS, PHILIP H ; GRIFFEY, STEPHEN M ; GREGORY, CLARE R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4575-a5cccf7c85b027f722332d57f45318a4c6372d6b301ab7a608e4c7609cc570cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Blood Urea Nitrogen</topic><topic>Cat Diseases - blood</topic><topic>Cat Diseases - diagnostic imaging</topic><topic>Cat Diseases - pathology</topic><topic>Cat Diseases - surgery</topic><topic>Cats</topic><topic>Creatinine - blood</topic><topic>Delayed Graft Function - veterinary</topic><topic>Female</topic><topic>graft rejection</topic><topic>Injuries</topic><topic>ischemia</topic><topic>Ischemia - veterinary</topic><topic>Kidney - blood supply</topic><topic>Kidney - diagnostic imaging</topic><topic>kidney transplant</topic><topic>Kidney Transplantation - methods</topic><topic>Kidney Transplantation - veterinary</topic><topic>Kidneys</topic><topic>physiological response</topic><topic>postoperative complications</topic><topic>Postoperative Complications - veterinary</topic><topic>renal function</topic><topic>Skin & tissue grafts</topic><topic>surgical transplantation</topic><topic>tissue repair</topic><topic>Transplants & implants</topic><topic>Ultrasonography</topic><topic>uremia</topic><topic>ureter</topic><topic>Ureteral Obstruction - veterinary</topic><topic>urinary tract</topic><topic>Urogenital system</topic><topic>Veterinary services</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MEHL, MARGO L</creatorcontrib><creatorcontrib>KYLES, ANDREW E</creatorcontrib><creatorcontrib>REIMER, S. BRENT</creatorcontrib><creatorcontrib>FLYNN, ALISON K</creatorcontrib><creatorcontrib>POLLARD, RACHEL E</creatorcontrib><creatorcontrib>NYLAND, TOM</creatorcontrib><creatorcontrib>KASS, PHILIP H</creatorcontrib><creatorcontrib>GRIFFEY, STEPHEN M</creatorcontrib><creatorcontrib>GREGORY, CLARE R</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MEHL, MARGO L</au><au>KYLES, ANDREW E</au><au>REIMER, S. BRENT</au><au>FLYNN, ALISON K</au><au>POLLARD, RACHEL E</au><au>NYLAND, TOM</au><au>KASS, PHILIP H</au><au>GRIFFEY, STEPHEN M</au><au>GREGORY, CLARE R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Effects of Ischemic Injury and Ureteral Obstruction on Delayed Graft Function in Cats After Renal Autotransplantation</atitle><jtitle>Veterinary surgery</jtitle><addtitle>Vet Surg</addtitle><date>2006-06</date><risdate>2006</risdate><volume>35</volume><issue>4</issue><spage>341</spage><epage>346</epage><pages>341-346</pages><issn>0161-3499</issn><eissn>1532-950X</eissn><abstract>To determine the relative importance of ischemic injury to delayed graft function (DGF) in cats. Experimental study. Six intact female cats. Cats had renal autograft transplantation without ureteral transection and reimplantation and a contralateral nephrectomy. Serum creatinine and blood urea nitrogen (BUN) concentrations were measured regularly and abdominal ultrasound was performed before surgery, the day after surgery and twice weekly thereafter. Ultrasound-guided renal biopsy was performed on day 7. Cats were euthanatized on day 21. Histology of the autograft, ureter, bladder, vascular anastomoses sites, and contralateral kidney were performed. Observations were compared with those from an historic group of research cats that had extravesicular ureteroneocystostomy and contralateral nephrectomy. ¹ Five cats completed the study. Serum creatinine and BUN concentrations increased after surgery, peaking at 3.2±0.8 and 77.6±15.9 mg/dL, respectively, 1-2 days after surgery. Serum creatinine concentration returned to the reference interval by 6 days after surgery. BUN gradually decreased in all cats but did not return to the reference interval by study end. Serum creatinine and BUN concentrations were consistently lower but not significantly so (P=.29 and .56, respectively) compared with the historic ureteroneocystostomy group. No ultrasonographic abnormalities or renal biopsy histologic abnormalities were observed. At necropsy, 1 autograft had generalized interstitial fibrosis. Harvesting the renal graft and the ischemia before revascularization causes impaired renal function after engraftment. The process of harvesting and reimplanting the renal graft can contribute to DGF in cats, independent of ureteral obstruction.</abstract><cop>Malden, USA</cop><pub>Malden, USA : Blackwell Publishing Inc</pub><pmid>16756614</pmid><doi>10.1111/j.1532-950X.2006.00155.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Veterinary surgery, 2006-06, Vol.35 (4), p.341-346 |
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| subjects | Animals Blood Urea Nitrogen Cat Diseases - blood Cat Diseases - diagnostic imaging Cat Diseases - pathology Cat Diseases - surgery Cats Creatinine - blood Delayed Graft Function - veterinary Female graft rejection Injuries ischemia Ischemia - veterinary Kidney - blood supply Kidney - diagnostic imaging kidney transplant Kidney Transplantation - methods Kidney Transplantation - veterinary Kidneys physiological response postoperative complications Postoperative Complications - veterinary renal function Skin & tissue grafts surgical transplantation tissue repair Transplants & implants Ultrasonography uremia ureter Ureteral Obstruction - veterinary urinary tract Urogenital system Veterinary services |
| title | Evaluation of the Effects of Ischemic Injury and Ureteral Obstruction on Delayed Graft Function in Cats After Renal Autotransplantation |
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