Dendritic Size of Pyramidal Neurons Differs among Mouse Cortical Regions

Neocortical circuits share anatomical and physiological similarities among different species and cortical areas. Because of this, a ‘canonical’ cortical microcircuit could form the functional unit of the neocortex and perform the same basic computation on different types of inputs. However, variatio...

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Veröffentlicht in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2006-07, Vol.16 (7), p.990-1001
Hauptverfasser: Benavides-Piccione, Ruth, Hamzei-Sichani, Farid, Ballesteros-Yáñez, Inmaculada, DeFelipe, Javier, Yuste, Rafael
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container_end_page 1001
container_issue 7
container_start_page 990
container_title Cerebral cortex (New York, N.Y. 1991)
container_volume 16
creator Benavides-Piccione, Ruth
Hamzei-Sichani, Farid
Ballesteros-Yáñez, Inmaculada
DeFelipe, Javier
Yuste, Rafael
description Neocortical circuits share anatomical and physiological similarities among different species and cortical areas. Because of this, a ‘canonical’ cortical microcircuit could form the functional unit of the neocortex and perform the same basic computation on different types of inputs. However, variations in pyramidal cell structure between different primate cortical areas exist, indicating that different cortical areas could be built out of different neuronal cell types. In the present study, we have investigated the dendritic architecture of 90 layer II/III pyramidal neurons located in different cortical regions along a rostrocaudal axis in the mouse neocortex, using, for the first time, a blind multidimensional analysis of over 150 morphological variables, rather than evaluating along single morphological parameters. These cortical regions included the secondary motor cortex (M2), the secondary somatosensory cortex (S2), and the lateral secondary visual cortex and association temporal cortex (V2L/TeA). Confirming earlier primate studies, we find that basal dendritic morphologies are characteristically different between different cortical regions. In addition, we demonstrate that these differences are not related to the physical location of the neuron and cannot be easily explained assuming rostrocaudal gradients within the cortex. Our data suggest that each cortical region is built with specific neuronal components.
doi_str_mv 10.1093/cercor/bhj041
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source MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals
subjects Animals
Cells, Cultured
Cerebral Cortex - cytology
Circuit
cluster analysis
Dendrites - ultrastructure
Lucifer Yellow
Mice
Nerve Net - cytology
PCA
Primates
Pyramidal Cells - cytology
title Dendritic Size of Pyramidal Neurons Differs among Mouse Cortical Regions
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