Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells

In the current study, we investigated the effect of simvastatin on the ability of high glucose (HG) and ANG II to activate the JAK2-STAT signaling cascade and induce glomerular mesangial cell (GMC) growth. We found that pretreatment with simvastatin significantly inhibited HG- and ANG II-induced col...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2006-07, Vol.291 (1), p.F116-F121
Hauptverfasser:	Banes-Berceli, Amy K, Shaw, Sean, Ma, Guochuan, Brands, Michael, Eaton, Douglas C, Stern, David M, Fulton, David, Caldwell, R William, Marrero, Mario B
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - physiology Animals Anticholesteremic Agents - pharmacology Blood Glucose - physiology Cells, Cultured Collagen Type IV - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetic Nephropathies - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation - drug effects Janus Kinase 2 Male Mesangial Cells - chemistry Mesangial Cells - drug effects Mesangial Cells - physiology Phosphorylation - drug effects Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism Rats Rats, Sprague-Dawley rho GTP-Binding Proteins - physiology Signal Transduction - drug effects Simvastatin - pharmacology STAT1 Transcription Factor - metabolism STAT3 Transcription Factor - metabolism Terpenes - pharmacology
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