Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography. To o...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2006-06, Vol.173 (12), p.1309-1315 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Hasegawa, Masaru Nasuhara, Yasuyuki Onodera, Yuya Makita, Hironi Nagai, Katsura Fuke, Satoshi Ito, Yoko Betsuyaku, Tomoko Nishimura, Masaharu |
| description | Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography.
To obtain longitudinal images and accurately analyze short axis images of airways with an inner diameter>or=2 mm located anywhere in the lung with new software for measuring airway dimensions using curved multiplanar reconstruction.
In 52 patients with clinically stable COPD (stage I, 14; stage II, 22; stage III, 14; stage IV, 2), we used the software to analyze the relationship of the airflow limitation index (FEV1, % predicted) with the airway dimensions from the third to the sixth generations of the apical bronchus (B1) of the right upper lobe and the anterior basal bronchus (B8) of the right lower lobe.
Airway luminal area (Ai) and wall area percent (WA%) were significantly correlated with FEV1 (% predicted). More importantly, the correlation coefficients (r) improved as the airways became smaller in size from the third (segmental) to sixth generations in both bronchi (Ai: r=0.26, 0.37, 0.58, and 0.64 for B1; r=0.60, 0.65, 0.63, and 0.73 for B8).
We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD is more closely related to the dimensions of the distal (small) airways than proximal (large) airways. |
| doi_str_mv | 10.1164/rccm.200601-037OC |
| format | Article |
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To obtain longitudinal images and accurately analyze short axis images of airways with an inner diameter>or=2 mm located anywhere in the lung with new software for measuring airway dimensions using curved multiplanar reconstruction.
In 52 patients with clinically stable COPD (stage I, 14; stage II, 22; stage III, 14; stage IV, 2), we used the software to analyze the relationship of the airflow limitation index (FEV1, % predicted) with the airway dimensions from the third to the sixth generations of the apical bronchus (B1) of the right upper lobe and the anterior basal bronchus (B8) of the right lower lobe.
Airway luminal area (Ai) and wall area percent (WA%) were significantly correlated with FEV1 (% predicted). More importantly, the correlation coefficients (r) improved as the airways became smaller in size from the third (segmental) to sixth generations in both bronchi (Ai: r=0.26, 0.37, 0.58, and 0.64 for B1; r=0.60, 0.65, 0.63, and 0.73 for B8).
We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD is more closely related to the dimensions of the distal (small) airways than proximal (large) airways.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200601-037OC</identifier><identifier>PMID: 16556695</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bronchi - pathology ; Bronchography ; Chronic obstructive pulmonary disease ; Chronic obstructive pulmonary disease, asthma ; Cohort Studies ; Emphysema ; Female ; Forced Expiratory Volume - physiology ; Functional Residual Capacity - physiology ; Humans ; Image Processing, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; Intensive care medicine ; Male ; Medical imaging ; Medical sciences ; Middle Aged ; Phantoms, Imaging ; Pneumology ; Pulmonary Diffusing Capacity - physiology ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary Disease, Chronic Obstructive - pathology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Pulmonary Ventilation - physiology ; Residual Volume - physiology ; Software ; Software Validation ; Tomography ; Tomography, X-Ray Computed ; Total Lung Capacity - physiology ; Vital Capacity - physiology ; Work stations</subject><ispartof>American journal of respiratory and critical care medicine, 2006-06, Vol.173 (12), p.1309-1315</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright American Thoracic Society Jun 15, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-fc4aaa749a4d2ce88aeec09504dd408f27e8c4e3ceeac501d21086d93d42e2f73</citedby><cites>FETCH-LOGICAL-c545t-fc4aaa749a4d2ce88aeec09504dd408f27e8c4e3ceeac501d21086d93d42e2f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4025,4026,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17859377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16556695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, Masaru</creatorcontrib><creatorcontrib>Nasuhara, Yasuyuki</creatorcontrib><creatorcontrib>Onodera, Yuya</creatorcontrib><creatorcontrib>Makita, Hironi</creatorcontrib><creatorcontrib>Nagai, Katsura</creatorcontrib><creatorcontrib>Fuke, Satoshi</creatorcontrib><creatorcontrib>Ito, Yoko</creatorcontrib><creatorcontrib>Betsuyaku, Tomoko</creatorcontrib><creatorcontrib>Nishimura, Masaharu</creatorcontrib><title>Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography.
To obtain longitudinal images and accurately analyze short axis images of airways with an inner diameter>or=2 mm located anywhere in the lung with new software for measuring airway dimensions using curved multiplanar reconstruction.
In 52 patients with clinically stable COPD (stage I, 14; stage II, 22; stage III, 14; stage IV, 2), we used the software to analyze the relationship of the airflow limitation index (FEV1, % predicted) with the airway dimensions from the third to the sixth generations of the apical bronchus (B1) of the right upper lobe and the anterior basal bronchus (B8) of the right lower lobe.
Airway luminal area (Ai) and wall area percent (WA%) were significantly correlated with FEV1 (% predicted). More importantly, the correlation coefficients (r) improved as the airways became smaller in size from the third (segmental) to sixth generations in both bronchi (Ai: r=0.26, 0.37, 0.58, and 0.64 for B1; r=0.60, 0.65, 0.63, and 0.73 for B8).
We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD is more closely related to the dimensions of the distal (small) airways than proximal (large) airways.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bronchi - pathology</subject><subject>Bronchography</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cohort Studies</subject><subject>Emphysema</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Functional Residual Capacity - physiology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phantoms, Imaging</subject><subject>Pneumology</subject><subject>Pulmonary Diffusing Capacity - physiology</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</subject><subject>Pulmonary Disease, Chronic Obstructive - pathology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Residual Volume - physiology</subject><subject>Software</subject><subject>Software Validation</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><subject>Total Lung Capacity - physiology</subject><subject>Vital Capacity - physiology</subject><subject>Work stations</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE2LFDEQhoMo7rr6A7xII-hFeq10Pjo5LuMnDIyCgrdQm652MnSn16TbwX9v2hlY8FSheOqt1MPYcw7XnGv5Nnk_XjcAGngNot1tHrBLroSqpW3hYXlDK2op7Y8L9iTnAwBvDIfH7IJrpbS26pJ9vQmpH6ZjtQ1jmHEOU6wwdlVpH_FP9S6MFHNp5irEarNPUwy-2t3mOS1-Dr-p-rIM4xQxrWwmzPSUPepxyPTsXK_Y9w_vv20-1dvdx8-bm23tlVRz3XuJiK20KLvGkzFI5MEqkF0nwfRNS8ZLEp4IvQLeNRyM7qzoZENN34or9vqUe5emXwvl2Y0hexoGjDQt2WkD0gKYAr78DzxMS4rlb45bq7XQZoX4CfJpyjlR7-5SGMtZjoNbZbtVtjvJdv9kl5kX5-DldqTufuJstwCvzgBmj0OfMPqQ77nWKCva9ZQ3J24ffu6PIZHLIw5DieUOD-ti3grHG8cFWPEX1veXtw</recordid><startdate>20060615</startdate><enddate>20060615</enddate><creator>Hasegawa, Masaru</creator><creator>Nasuhara, Yasuyuki</creator><creator>Onodera, Yuya</creator><creator>Makita, Hironi</creator><creator>Nagai, Katsura</creator><creator>Fuke, Satoshi</creator><creator>Ito, Yoko</creator><creator>Betsuyaku, Tomoko</creator><creator>Nishimura, Masaharu</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20060615</creationdate><title>Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease</title><author>Hasegawa, Masaru ; Nasuhara, Yasuyuki ; Onodera, Yuya ; Makita, Hironi ; Nagai, Katsura ; Fuke, Satoshi ; Ito, Yoko ; Betsuyaku, Tomoko ; Nishimura, Masaharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-fc4aaa749a4d2ce88aeec09504dd408f27e8c4e3ceeac501d21086d93d42e2f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bronchi - pathology</topic><topic>Bronchography</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cohort Studies</topic><topic>Emphysema</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Functional Residual Capacity - physiology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phantoms, Imaging</topic><topic>Pneumology</topic><topic>Pulmonary Diffusing Capacity - physiology</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</topic><topic>Pulmonary Disease, Chronic Obstructive - pathology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Residual Volume - physiology</topic><topic>Software</topic><topic>Software Validation</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><topic>Total Lung Capacity - physiology</topic><topic>Vital Capacity - physiology</topic><topic>Work stations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Masaru</creatorcontrib><creatorcontrib>Nasuhara, Yasuyuki</creatorcontrib><creatorcontrib>Onodera, Yuya</creatorcontrib><creatorcontrib>Makita, Hironi</creatorcontrib><creatorcontrib>Nagai, Katsura</creatorcontrib><creatorcontrib>Fuke, Satoshi</creatorcontrib><creatorcontrib>Ito, Yoko</creatorcontrib><creatorcontrib>Betsuyaku, Tomoko</creatorcontrib><creatorcontrib>Nishimura, Masaharu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Masaru</au><au>Nasuhara, Yasuyuki</au><au>Onodera, Yuya</au><au>Makita, Hironi</au><au>Nagai, Katsura</au><au>Fuke, Satoshi</au><au>Ito, Yoko</au><au>Betsuyaku, Tomoko</au><au>Nishimura, Masaharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2006-06-15</date><risdate>2006</risdate><volume>173</volume><issue>12</issue><spage>1309</spage><epage>1315</epage><pages>1309-1315</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography.
To obtain longitudinal images and accurately analyze short axis images of airways with an inner diameter>or=2 mm located anywhere in the lung with new software for measuring airway dimensions using curved multiplanar reconstruction.
In 52 patients with clinically stable COPD (stage I, 14; stage II, 22; stage III, 14; stage IV, 2), we used the software to analyze the relationship of the airflow limitation index (FEV1, % predicted) with the airway dimensions from the third to the sixth generations of the apical bronchus (B1) of the right upper lobe and the anterior basal bronchus (B8) of the right lower lobe.
Airway luminal area (Ai) and wall area percent (WA%) were significantly correlated with FEV1 (% predicted). More importantly, the correlation coefficients (r) improved as the airways became smaller in size from the third (segmental) to sixth generations in both bronchi (Ai: r=0.26, 0.37, 0.58, and 0.64 for B1; r=0.60, 0.65, 0.63, and 0.73 for B8).
We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD is more closely related to the dimensions of the distal (small) airways than proximal (large) airways.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>16556695</pmid><doi>10.1164/rccm.200601-037OC</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2006-06, Vol.173 (12), p.1309-1315 |
| issn | 1073-449X 1535-4970 |
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| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bronchi - pathology Bronchography Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Cohort Studies Emphysema Female Forced Expiratory Volume - physiology Functional Residual Capacity - physiology Humans Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional - methods Intensive care medicine Male Medical imaging Medical sciences Middle Aged Phantoms, Imaging Pneumology Pulmonary Diffusing Capacity - physiology Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Pulmonary Ventilation - physiology Residual Volume - physiology Software Software Validation Tomography Tomography, X-Ray Computed Total Lung Capacity - physiology Vital Capacity - physiology Work stations |
| title | Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease |
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