Self-reactive CD4+ T cells and B cells in the blood in health and autoimmune disease: increased frequency of thyroglobulin-reactive cells in Graves' disease

The mechanisms underlying activation of potentially self-reactive circulating B cells and T cells remain unclear. We measured the uptake of a self-antigen, thyroglobulin, by antigen presenting cells, and the subsequent proliferation of CD4(+) T cells and B cells from healthy controls and patients wi...

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Veröffentlicht in:	Journal of clinical immunology 2006-03, Vol.26 (2), p.126-137
Hauptverfasser:	Nielsen, Claus H, Moeller, Ane Christine, Hegedüs, Laszlo, Bendtzen, Klaus, Leslie, R Graham Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantibodies - immunology B-Lymphocytes - immunology CD4-Positive T-Lymphocytes - immunology Complement System Proteins - immunology Graves Disease - blood Graves Disease - immunology Hashimoto Disease - blood Hashimoto Disease - immunology Humans Lymphocyte Activation - drug effects Thyroglobulin - blood Thyroglobulin - immunology Thyroglobulin - pharmacology
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