PET neuroimaging of [ 11C]mirtazapine enantiomers in pigs

Previously, we used positron emission tomography (PET) for studying the pharmacokinetics of rac-[ 11C]mirtazapine in living brain. Our findings showed that rac-[ 11C]mirtazapine has suitable properties for PET neuroimaging. However, separate studies of enantiomers are typically required for characte...

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Veröffentlicht in:	European neuropsychopharmacology 2006-07, Vol.16 (5), p.350-357
Hauptverfasser:	Smith, Donald F., Marthi, Katalin, Munk, Ole L., Cumming, Paul, Hansen, Søren B., Jakobsen, Steen
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 11C]Mirtazapine Animals Antidepressant Blood Chemical Analysis Brain - diagnostic imaging Carbon Radioisotopes Enantiomers Female Injections, Intravenous Isotope Labeling Mianserin - analogs & derivatives Mianserin - blood Mianserin - pharmacokinetics PET neuroimaging Pharmacokinetics Porcine brain Positron-Emission Tomography Radiometry Radiopharmaceuticals - blood Radiopharmaceuticals - pharmacokinetics Stereoisomerism Swine Whole-Body Counting
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