Photo- and Thermal-Stability Studies on Benzimidazole Anthelmintics by HPLC and GC-MS

Photo- and thermal-stability of the anthelmintics Albendazole, Mebendazole and Fenbendazole as in solid as in solution form has been investigated, by using a Xenon arc lamp as a radiation source, according to the ICH guideline for the drug stability tests. The degradation process was monitored by a...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2006, Vol.54(6), pp.802-806
Hauptverfasser:	Ragno, Gaetano, Risoli, Antonella, Ioele, Giuseppina, Luca, Michele De
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthelmintics - chemistry benzimidazole anthelmintics Benzimidazoles - chemistry Chemistry, Pharmaceutical Chromatography, High Pressure Liquid - methods Drug Stability Gas Chromatography-Mass Spectrometry - methods GC-MS HPLC Photochemistry photodegradation Temperature thermal-degradation
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