Prevention of Immune Responses to Human Erythropoietin in Cynomolgus Monkeys (Macaca fascicularis)

Genes and proteins of human origin are often administered to monkeys for research purposes, however, it can be difficult to obtain sufficient levels of the products in vivo due to immunological clearance. In this study, we showed that human erythropoietin (hEPO) induces generation of anti-hEPO antib...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2006, Vol.68(5), pp.507-510
Hauptverfasser:	AGEYAMA, Naohide, HANAZONO, Yutaka, SHIBATA, Hiroaki, ONO, Fumiko, NAGASHIMA, Takeyuki, UEDA, Yasuji, YOSHIKAWA, Yasuhiro, HASEGAWA, Mamoru, OZAWA, Keiya, TERAO, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - blood Antibody Formation - drug effects cyclosporin A Cyclosporine - pharmacology Cynomolgus cynomolgus monkey erythropoietin Erythropoietin - immunology Female Hemoglobins - analysis Humans Hypersensitivity, Immediate - prevention & control Hypersensitivity, Immediate - veterinary Immunosuppressive Agents - pharmacology Macaca fascicularis Macaca fascicularis - blood Macaca fascicularis - immunology Male
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