Lactosylceramide in lysosomal storage disorders. A comparative immunohistochemical and biochemical study

Immunohistochemical studies of the presence of lactosylceramide (LacCer) in lysosomal storage disorders (LSDs) were done using anti-LacCer monoclonal antibody of the CDw 17 type (clone MG-2). No sign of an association between LacCer and the lysosomal system in normal cells was observed, except for h...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2005-07, Vol.447 (1), p.31-44
Hauptverfasser:	HULKOVA, H, LEDVINOVA, J, ASFAW, B, KOUBEK, K, KOPRIVA, K, ELLEDER, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, CD - analysis Antigens, CD - metabolism Biological and medical sciences Biomarkers - analysis Cerebral Cortex - chemistry Cerebral Cortex - metabolism Cerebral Cortex - pathology Child Chromatography, Thin Layer - methods Comparative studies Histiocytes - chemistry Histiocytes - metabolism Histiocytes - pathology Humans Immunohistochemistry - methods Investigative techniques, diagnostic techniques (general aspects) Lactosylceramides - analysis Lactosylceramides - metabolism Liver - chemistry Liver - metabolism Liver - pathology Lysosomal Storage Diseases - classification Lysosomal Storage Diseases - metabolism Lysosomal Storage Diseases - pathology Macrophages - chemistry Macrophages - metabolism Macrophages - pathology Medical sciences Neurons - chemistry Neurons - metabolism Neurons - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Spleen - chemistry Spleen - metabolism Spleen - pathology Thin layer chromatography
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