Differentiation Between Cerebrospinal Fluid and Serum with Electronic Nose
The study investigates the ability of the electronic nose to differentiate between cerebrospinal fluid (CSF) and serum and to identify an unknown specimen as CSF or serum. CSF and serum specimens were heated and tested with an organic semiconductor-based Cyranose 320 electronic nose (Cyrons Sciences...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2005-07, Vol.133 (1), p.16-19 |
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| container_title | Otolaryngology-head and neck surgery |
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| creator | Aronzon, Anna Hanson, C. William Thaler, Erica R. |
| description | The study investigates the ability of the electronic nose to differentiate between cerebrospinal fluid (CSF) and serum and to identify an unknown specimen as CSF or serum.
CSF and serum specimens were heated and tested with an organic semiconductor-based Cyranose 320 electronic nose (Cyrons Sciences, Pasadena, CA). Data from the 32-element sensor array were subjected to principal component analysis to depict differences in odorant patterns.
The electronic nose was able to distinguish between CSF and serum isolates with Mahalanobis distance >5. Furthermore, the electronic nose was able to place unknown specimens in the appropriate class of CSF or serum.
The electronic nose is a novel method that may allow rapid, low cost, and reliable distinction between CSF and serum in a clinical setting.
Because the results are available almost immediately, the electronic nose is a powerful tool that in the future may allow for rapid diagnosis of CSF leaks in the office setting. |
| doi_str_mv | 10.1016/j.otohns.2005.03.021 |
| format | Article |
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CSF and serum specimens were heated and tested with an organic semiconductor-based Cyranose 320 electronic nose (Cyrons Sciences, Pasadena, CA). Data from the 32-element sensor array were subjected to principal component analysis to depict differences in odorant patterns.
The electronic nose was able to distinguish between CSF and serum isolates with Mahalanobis distance >5. Furthermore, the electronic nose was able to place unknown specimens in the appropriate class of CSF or serum.
The electronic nose is a novel method that may allow rapid, low cost, and reliable distinction between CSF and serum in a clinical setting.
Because the results are available almost immediately, the electronic nose is a powerful tool that in the future may allow for rapid diagnosis of CSF leaks in the office setting.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1016/j.otohns.2005.03.021</identifier><identifier>PMID: 16025046</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Cerebrospinal Fluid - chemistry ; Clinical Chemistry Tests - instrumentation ; Diagnostic Techniques and Procedures - instrumentation ; Electronics - instrumentation ; Humans ; Serum - chemistry ; Specimen Handling - instrumentation</subject><ispartof>Otolaryngology-head and neck surgery, 2005-07, Vol.133 (1), p.16-19</ispartof><rights>2005 American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc.</rights><rights>2005 Official journal of the American Academy of Otolaryngology–Head and Neck Surgery Foundation</rights><rights>2005 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4550-7a6c5bf02b0ed7db7d211c4d89a0de99d563db1af0e3ea3f731e73053d9b78373</citedby><cites>FETCH-LOGICAL-c4550-7a6c5bf02b0ed7db7d211c4d89a0de99d563db1af0e3ea3f731e73053d9b78373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2005.03.021$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1016/j.otohns.2005.03.021$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,1411,21798,27901,27902,43597,43598,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16025046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aronzon, Anna</creatorcontrib><creatorcontrib>Hanson, C. William</creatorcontrib><creatorcontrib>Thaler, Erica R.</creatorcontrib><title>Differentiation Between Cerebrospinal Fluid and Serum with Electronic Nose</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>The study investigates the ability of the electronic nose to differentiate between cerebrospinal fluid (CSF) and serum and to identify an unknown specimen as CSF or serum.
CSF and serum specimens were heated and tested with an organic semiconductor-based Cyranose 320 electronic nose (Cyrons Sciences, Pasadena, CA). Data from the 32-element sensor array were subjected to principal component analysis to depict differences in odorant patterns.
The electronic nose was able to distinguish between CSF and serum isolates with Mahalanobis distance >5. Furthermore, the electronic nose was able to place unknown specimens in the appropriate class of CSF or serum.
The electronic nose is a novel method that may allow rapid, low cost, and reliable distinction between CSF and serum in a clinical setting.
Because the results are available almost immediately, the electronic nose is a powerful tool that in the future may allow for rapid diagnosis of CSF leaks in the office setting.</description><subject>Cerebrospinal Fluid - chemistry</subject><subject>Clinical Chemistry Tests - instrumentation</subject><subject>Diagnostic Techniques and Procedures - instrumentation</subject><subject>Electronics - instrumentation</subject><subject>Humans</subject><subject>Serum - chemistry</subject><subject>Specimen Handling - instrumentation</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EokvpGyCUE7eEcRzbiYSQ6LZLQVV7gJ4tx55Qr7L2Yies-va4ykrcaE-WRv_3a_wNIe8oVBSo-LitwhTufapqAF4Bq6CmL8iKQidL0VL5kqyAdk3Ju649IW9S2gKAEFK-JidUQM2hESvy_cINA0b0k9OTC744x-mA6It1HvYxpL3zeiw24-xsob0tfmCcd8XBTffF5YhmisE7U9yEhG_Jq0GPCc-O7ym521z-XF-V17dfv62_XJem4RxKqYXh_QB1D2il7aWtKTWNbTsNFrvOcsFsT_UAyFCzQTKKkgFntutlyyQ7JR-W3n0Mv2dMk9q5ZHActccwJyVaaCSIOgebJWjyP1LEQe2j2-n4oCioR4dqqxaH6tGhAqayw4y9P_bP_Q7tP-goLQc-LYGDG_HhWaXq9urmfAO8riHjdMGT_oVqG-aYDaendvq8MJjF_nEYVTIOvUHrYj6CssH9v-AvSeqn8Q</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Aronzon, Anna</creator><creator>Hanson, C. William</creator><creator>Thaler, Erica R.</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200507</creationdate><title>Differentiation Between Cerebrospinal Fluid and Serum with Electronic Nose</title><author>Aronzon, Anna ; Hanson, C. William ; Thaler, Erica R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4550-7a6c5bf02b0ed7db7d211c4d89a0de99d563db1af0e3ea3f731e73053d9b78373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Cerebrospinal Fluid - chemistry</topic><topic>Clinical Chemistry Tests - instrumentation</topic><topic>Diagnostic Techniques and Procedures - instrumentation</topic><topic>Electronics - instrumentation</topic><topic>Humans</topic><topic>Serum - chemistry</topic><topic>Specimen Handling - instrumentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aronzon, Anna</creatorcontrib><creatorcontrib>Hanson, C. William</creatorcontrib><creatorcontrib>Thaler, Erica R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aronzon, Anna</au><au>Hanson, C. William</au><au>Thaler, Erica R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiation Between Cerebrospinal Fluid and Serum with Electronic Nose</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2005-07</date><risdate>2005</risdate><volume>133</volume><issue>1</issue><spage>16</spage><epage>19</epage><pages>16-19</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>The study investigates the ability of the electronic nose to differentiate between cerebrospinal fluid (CSF) and serum and to identify an unknown specimen as CSF or serum.
CSF and serum specimens were heated and tested with an organic semiconductor-based Cyranose 320 electronic nose (Cyrons Sciences, Pasadena, CA). Data from the 32-element sensor array were subjected to principal component analysis to depict differences in odorant patterns.
The electronic nose was able to distinguish between CSF and serum isolates with Mahalanobis distance >5. Furthermore, the electronic nose was able to place unknown specimens in the appropriate class of CSF or serum.
The electronic nose is a novel method that may allow rapid, low cost, and reliable distinction between CSF and serum in a clinical setting.
Because the results are available almost immediately, the electronic nose is a powerful tool that in the future may allow for rapid diagnosis of CSF leaks in the office setting.</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>16025046</pmid><doi>10.1016/j.otohns.2005.03.021</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-5998 |
| ispartof | Otolaryngology-head and neck surgery, 2005-07, Vol.133 (1), p.16-19 |
| issn | 0194-5998 1097-6817 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68047062 |
| source | SAGE Complete A-Z List; MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Cerebrospinal Fluid - chemistry Clinical Chemistry Tests - instrumentation Diagnostic Techniques and Procedures - instrumentation Electronics - instrumentation Humans Serum - chemistry Specimen Handling - instrumentation |
| title | Differentiation Between Cerebrospinal Fluid and Serum with Electronic Nose |
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