Detailed Description of the Conformation and Location of Membrane-Bound Erythromycin A Using Isotropic Bicelles

Although many nonpeptidic drugs target biological membrane and membrane proteins, it is still difficult to define the membrane-bound structure of the drugs. In this study, we utilized bicelles as a membrane model, since the bicelles, which have planar lipid bilayer portions, are thought to be a more...

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Veröffentlicht in:Journal of medicinal chemistry 2006-06, Vol.49 (12), p.3501-3508
Hauptverfasser: Matsumori, Nobuaki, Morooka, Atsushi, Murata, Michio
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Sprache:eng
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