14-3-3 proteins in cell cycle regulation

Co-ordinated progression through the cell cycle is essential for the maintenance of genomic integrity. Several checkpoint mechanisms guarantee that the next step in cell cycle progression is only entered after error-free completion of the previous phase. Cell cycle deregulation caused by changes in...

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Veröffentlicht in:	Seminars in cancer biology 2006-06, Vol.16 (3), p.183-192
Hauptverfasser:	Hermeking, Heiko, Benzinger, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 14-3-3 Proteins - chemistry 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism 14-3-3σ Animals CDC2-cyclin B CDC25 cdc25 Phosphatases - metabolism Cell cycle Cell Cycle - genetics Cell Cycle - physiology Cyclin-Dependent Kinases - metabolism Cyclins - metabolism DNA Damage E2F1 Transcription Factor - metabolism Eukaryotic Cells - cytology G1 Phase G2 Phase Humans Mitosis Protein Isoforms - metabolism S Phase Signal Transduction - physiology Transcription Factors - metabolism Tumor Suppressor Protein p53 - metabolism
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