effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet
The objective of this study was to evaluate the effects of local Lactobacillus strains (NTU 101 and 102) on cholesterol-lowering effects in vivo. Thirty male hamsters were housed, divided into five groups, and fed on a cholesterol diet (5 g/kg diet) to induce hypercholesterolemia. Milk fermented by...
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| description | The objective of this study was to evaluate the effects of local Lactobacillus strains (NTU 101 and 102) on cholesterol-lowering effects in vivo. Thirty male hamsters were housed, divided into five groups, and fed on a cholesterol diet (5 g/kg diet) to induce hypercholesterolemia. Milk fermented by Lactobacillus paracasei subsp. paracasei NTU 101, Lactobacillus plantarum NTU 102, and Lactobacillus acidophilus BCRC 17010 was administrated for this study. After treatment with different fermented milk, blood was taken and liver was removed for the determination of lipoproteins, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride. Lactobacilli and bifidobacteria decreased (10⁵) in the control group; when hamsters were fed on fermented milk, the number of lactobacilli (10⁷-10⁸) and bifidobacteria (10⁵-10⁷) was increased. Serum and liver total cholesterol levels were significantly reduced by about 26.4, 23.5, and 30.1% and by about 17.7, 15.9, and 13.4% when hamsters were given fermented milk. However, serum HDL-C and LDL-C were also reduced. The results of this study showed that the hypocholesterolemic effect of local Lactobacillus strains was attributed to its ability to lower serum and liver total cholesterol levels. Thus, local Lactobacillus strains could significantly increase probiotic count. |
| doi_str_mv | 10.1007/s00253-005-0145-0 |
| format | Article |
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Thirty male hamsters were housed, divided into five groups, and fed on a cholesterol diet (5 g/kg diet) to induce hypercholesterolemia. Milk fermented by Lactobacillus paracasei subsp. paracasei NTU 101, Lactobacillus plantarum NTU 102, and Lactobacillus acidophilus BCRC 17010 was administrated for this study. After treatment with different fermented milk, blood was taken and liver was removed for the determination of lipoproteins, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride. Lactobacilli and bifidobacteria decreased (10⁵) in the control group; when hamsters were fed on fermented milk, the number of lactobacilli (10⁷-10⁸) and bifidobacteria (10⁵-10⁷) was increased. Serum and liver total cholesterol levels were significantly reduced by about 26.4, 23.5, and 30.1% and by about 17.7, 15.9, and 13.4% when hamsters were given fermented milk. However, serum HDL-C and LDL-C were also reduced. The results of this study showed that the hypocholesterolemic effect of local Lactobacillus strains was attributed to its ability to lower serum and liver total cholesterol levels. Thus, local Lactobacillus strains could significantly increase probiotic count.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-005-0145-0</identifier><identifier>PMID: 16172889</identifier><identifier>CODEN: AMBIDG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Bifidobacterium - metabolism ; Biological and medical sciences ; Biotechnology ; Cecum - microbiology ; Cholesterol ; Cholesterol - blood ; Cholesterol, Dietary - administration & dosage ; Colony Count, Microbial ; Cricetinae ; Cultured Milk Products ; Diet ; Feces - microbiology ; Fundamental and applied biological sciences. Psychology ; High density lipoprotein ; Hypercholesterolemia - metabolism ; Hypercholesterolemia - microbiology ; Lactobacillus - metabolism ; Lactobacillus acidophilus ; Lactobacillus paracasei ; Lactobacillus plantarum ; Lipid Metabolism ; Liver - metabolism ; Low density lipoprotein ; Male ; Mesocricetus ; Milk ; Random Allocation</subject><ispartof>Applied microbiology and biotechnology, 2006-06, Vol.71 (2), p.238-245</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-e213dff0c3b57f8055c5140edc1b112746ad34711bbba837e327fd06e43e7e23</citedby><cites>FETCH-LOGICAL-c477t-e213dff0c3b57f8055c5140edc1b112746ad34711bbba837e327fd06e43e7e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17900967$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16172889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiu, C.H</creatorcontrib><creatorcontrib>Lu, T.Y</creatorcontrib><creatorcontrib>Tseng, Y.Y</creatorcontrib><creatorcontrib>Pan, T.M</creatorcontrib><title>effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><description>The objective of this study was to evaluate the effects of local Lactobacillus strains (NTU 101 and 102) on cholesterol-lowering effects in vivo. Thirty male hamsters were housed, divided into five groups, and fed on a cholesterol diet (5 g/kg diet) to induce hypercholesterolemia. Milk fermented by Lactobacillus paracasei subsp. paracasei NTU 101, Lactobacillus plantarum NTU 102, and Lactobacillus acidophilus BCRC 17010 was administrated for this study. After treatment with different fermented milk, blood was taken and liver was removed for the determination of lipoproteins, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride. Lactobacilli and bifidobacteria decreased (10⁵) in the control group; when hamsters were fed on fermented milk, the number of lactobacilli (10⁷-10⁸) and bifidobacteria (10⁵-10⁷) was increased. Serum and liver total cholesterol levels were significantly reduced by about 26.4, 23.5, and 30.1% and by about 17.7, 15.9, and 13.4% when hamsters were given fermented milk. However, serum HDL-C and LDL-C were also reduced. The results of this study showed that the hypocholesterolemic effect of local Lactobacillus strains was attributed to its ability to lower serum and liver total cholesterol levels. Thus, local Lactobacillus strains could significantly increase probiotic count.</description><subject>Animals</subject><subject>Bifidobacterium - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cecum - microbiology</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, Dietary - administration & dosage</subject><subject>Colony Count, Microbial</subject><subject>Cricetinae</subject><subject>Cultured Milk Products</subject><subject>Diet</subject><subject>Feces - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>High density lipoprotein</subject><subject>Hypercholesterolemia - metabolism</subject><subject>Hypercholesterolemia - microbiology</subject><subject>Lactobacillus - metabolism</subject><subject>Lactobacillus acidophilus</subject><subject>Lactobacillus paracasei</subject><subject>Lactobacillus plantarum</subject><subject>Lipid Metabolism</subject><subject>Liver - metabolism</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Mesocricetus</subject><subject>Milk</subject><subject>Random Allocation</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0U2PFCEQBmBiNO64-gO8aMdEb61VQEP30Wz8Sibx4HomNF3ssNLNCN0H_71MZpJNvHiBQB4qVbyMvUR4jwD6QwHgnWgBuhZQ1uUR26EUvAWF8jHbAequ1d3QX7FnpdwDIO-VesquUKHmfT_s2ETek1tLk3yzt25No3Uhxq20nvJMy0pTM4f4q0lLE8Mx1BOtdkwxlLkJS3Owc1kpl8ZXWM0h3B1ad0iRTtcpNlOg9Tl74m0s9OKyX7Pbz59ub762--9fvt183LdOar22xFFM3oMTY6d9D13nOpRAk8MRkWup7CSkRhzH0fZCk-DaT6BICtLExTV7dy57zOn3VhswcyiOYrQLpa0Y1YOsc8N_IYf6TdVW-OYfeJ-2vNQZjOKdrh0qWRGekcuplEzeHHOYbf5jEMwpJ3POydSczCknc-rg1aXwNs40Pby4BFPB2wuwxdnos11cKA9ODwCD0tW9Pjtvk7F3uZqfPzigAIQBuQLxF_Xqo40</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Chiu, C.H</creator><creator>Lu, T.Y</creator><creator>Tseng, Y.Y</creator><creator>Pan, T.M</creator><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet</title><author>Chiu, C.H ; Lu, T.Y ; Tseng, Y.Y ; Pan, T.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-e213dff0c3b57f8055c5140edc1b112746ad34711bbba837e327fd06e43e7e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Bifidobacterium - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cecum - microbiology</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, Dietary - administration & dosage</topic><topic>Colony Count, Microbial</topic><topic>Cricetinae</topic><topic>Cultured Milk Products</topic><topic>Diet</topic><topic>Feces - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>High density lipoprotein</topic><topic>Hypercholesterolemia - metabolism</topic><topic>Hypercholesterolemia - microbiology</topic><topic>Lactobacillus - metabolism</topic><topic>Lactobacillus acidophilus</topic><topic>Lactobacillus paracasei</topic><topic>Lactobacillus plantarum</topic><topic>Lipid Metabolism</topic><topic>Liver - metabolism</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Mesocricetus</topic><topic>Milk</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiu, C.H</creatorcontrib><creatorcontrib>Lu, T.Y</creatorcontrib><creatorcontrib>Tseng, Y.Y</creatorcontrib><creatorcontrib>Pan, T.M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ProQuest Biological Science Collection</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiu, C.H</au><au>Lu, T.Y</au><au>Tseng, Y.Y</au><au>Pan, T.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet</atitle><jtitle>Applied microbiology and biotechnology</jtitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>71</volume><issue>2</issue><spage>238</spage><epage>245</epage><pages>238-245</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><coden>AMBIDG</coden><abstract>The objective of this study was to evaluate the effects of local Lactobacillus strains (NTU 101 and 102) on cholesterol-lowering effects in vivo. Thirty male hamsters were housed, divided into five groups, and fed on a cholesterol diet (5 g/kg diet) to induce hypercholesterolemia. Milk fermented by Lactobacillus paracasei subsp. paracasei NTU 101, Lactobacillus plantarum NTU 102, and Lactobacillus acidophilus BCRC 17010 was administrated for this study. After treatment with different fermented milk, blood was taken and liver was removed for the determination of lipoproteins, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride. Lactobacilli and bifidobacteria decreased (10⁵) in the control group; when hamsters were fed on fermented milk, the number of lactobacilli (10⁷-10⁸) and bifidobacteria (10⁵-10⁷) was increased. Serum and liver total cholesterol levels were significantly reduced by about 26.4, 23.5, and 30.1% and by about 17.7, 15.9, and 13.4% when hamsters were given fermented milk. However, serum HDL-C and LDL-C were also reduced. The results of this study showed that the hypocholesterolemic effect of local Lactobacillus strains was attributed to its ability to lower serum and liver total cholesterol levels. Thus, local Lactobacillus strains could significantly increase probiotic count.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16172889</pmid><doi>10.1007/s00253-005-0145-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Bifidobacterium - metabolism Biological and medical sciences Biotechnology Cecum - microbiology Cholesterol Cholesterol - blood Cholesterol, Dietary - administration & dosage Colony Count, Microbial Cricetinae Cultured Milk Products Diet Feces - microbiology Fundamental and applied biological sciences. Psychology High density lipoprotein Hypercholesterolemia - metabolism Hypercholesterolemia - microbiology Lactobacillus - metabolism Lactobacillus acidophilus Lactobacillus paracasei Lactobacillus plantarum Lipid Metabolism Liver - metabolism Low density lipoprotein Male Mesocricetus Milk Random Allocation |
| title | effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet |
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