SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation

Vertebrate skeletogenesis involves two processes, skeletal patterning and osteoblast differentiation. Here, we show that Satb2, encoding a nuclear matrix protein, is expressed in branchial arches and in cells of the osteoblast lineage. Satb2−/− mice exhibit both craniofacial abnormalities that resem...

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Veröffentlicht in:	Cell 2006-06, Vol.125 (5), p.971-986
Hauptverfasser:	Dobreva, Gergana, Chahrour, Maria, Dautzenberg, Marcel, Chirivella, Laura, Kanzler, Benoit, Fariñas, Isabel, Karsenty, Gerard, Grosschedl, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 4 - genetics Animals Body Patterning - genetics Branchial Region - abnormalities Branchial Region - cytology Branchial Region - metabolism Cell Differentiation - genetics Core Binding Factor Alpha 1 Subunit - genetics Craniofacial Abnormalities - genetics Craniofacial Abnormalities - metabolism Craniofacial Abnormalities - physiopathology Facial Bones - abnormalities Facial Bones - metabolism Gene Expression Regulation, Developmental - genetics Genes, Homeobox - genetics Homeodomain Proteins - genetics Matrix Attachment Region Binding Proteins - genetics Mice Mice, Knockout Mutation - genetics Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis - genetics Repressor Proteins - genetics Skull - abnormalities Transcription Factors - genetics
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