Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation

Nutritional status has a major impact on the immune response and this is in part mediated by leptin, a pro-inflammatory cytokine. Preliminary data suggest that antagonism of leptin may offer a therapeutic approach for the treatment of some inflammatory disorders. We have tested monoclonal antibodies...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of immunological methods 2006-05, Vol.312 (1), p.190-200
Hauptverfasser:	Fazeli, Mehdi, Zarkesh-Esfahani, Hamid, Wu, Zida, Maamra, Mabrouka, Bidlingmaier, Martin, Pockley, A. Graham, Watson, Philip, Matarese, Giuseppe, Strasburger, Christian J., Ross, Richard J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagonist Antibodies Antibodies, Monoclonal - genetics Antibodies, Monoclonal - isolation & purification Antibodies, Monoclonal - pharmacology antigen binding fragment Biological and medical sciences c-sis inducible element Cytokine receptors Dose-Response Relationship, Immunologic Escherichia coli Fab Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - genetics Jak/STAT Janus kinase/signal transducers and activators of transcription leptin leptin receptor Lymphocyte Activation - drug effects mAb MAPK mitogen activated protein kinase Molecular immunology monoclonal antibody Monocytes Monocytes - drug effects Monocytes - immunology ObR PBMC peripheral blood mononuclear cell Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - immunology Receptors, Leptin Recombinant Proteins - biosynthesis Recombinant Proteins - genetics SIE Signal Transduction T cells T-Lymphocytes - drug effects T-Lymphocytes - immunology Techniques TNF-α tumor necrosis factor alpha Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!