Inhibition of in vivo angiogenesis by N-β-alanyl-5- S-glutathionyl-3,4-dihydroxyphenylalanine

N-β-alanyl-5- S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), an antibacterial substance isolated from the flesh fly, inhibits human tumor growth in the nude mice model; however, the mechanism of its action is unclear. The in vivo antitumor effect includes the inhibition of tumor cell prolifera...

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Veröffentlicht in:	European journal of pharmacology 2006-06, Vol.539 (3), p.151-157
Hauptverfasser:	Nishikawa, Takeshi, Akiyama, Nobuko, Kunimasa, Kazuhiro, Oikawa, Tsutomu, Ishizuka, Masaaki, Tsujimoto, Masafumi, Natori, Shunji
Format:	Artikel
Sprache:	eng
Schlagworte:	5-S-GAD Angiogenesis Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Antiangiogenic agent Biological and medical sciences Cell Line, Tumor Chick Embryo Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - pharmacology Dihydroxyphenylalanine - therapeutic use Dose-Response Relationship, Drug Female Glutathione - analogs & derivatives Glutathione - pharmacology Glutathione - therapeutic use Humans Medical sciences Mice Mice, Inbred C57BL Mice, Inbred ICR Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Pharmacology. Drug treatments Tumor therapy Xenograft Model Antitumor Assays - methods
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