Seven Years of HAART Impact on Ophthalmic Management of HIV-Infected Patients
Purpose: The widespread use of highly active antiretroviral therapy (HAART) has changed the clinical picture of HIV-associated eye disease. We evaluated the incidence of ocular manifestations of HIV infection since the introduction of HAART. Methods: Between January 1996 and December 2002, we examin...
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| Veröffentlicht in: | Ocular immunology and inflammation 2005-04, Vol.13 (2-3), p.213-218 |
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| container_title | Ocular immunology and inflammation |
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| creator | Kahraman, Günal Krepler, Katharina Franz, Carmen Ries, Eva Maar, Noemi Wedrich, Andreas Rieger, Armin Dejaco-Ruhswurm, Irene |
| description | Purpose: The widespread use of highly active antiretroviral therapy (HAART) has changed the clinical picture of HIV-associated eye disease. We evaluated the incidence of ocular manifestations of HIV infection since the introduction of HAART. Methods: Between January 1996 and December 2002, we examined 539 HIV-infected patients in our hospital. Follow-up of the patients was performed in case of ophthalmologic symptoms, regardless of current immunologic status, or for screening. Results: A total of 217 patients (40.3%) had HIV-associated eye disease. Of these patients, 42.0% had no eye symptoms. Fifty-eight (10.8%) of the 539 patients had cytomegalovirus (CMV) retinitis, most of whom had CMV retinitis before receiving HAART. Four patients developed immune-recovery uveitis. A total of 145 patients (26.9%) had HIV-related microangiopathy and 96 (17.8%) had dry-eye syndrome. Conclusion: The introduction of HAART had a major impact on the medical history of patients with HIV-related eye disease with improved survival time and decreased morbidity. |
| doi_str_mv | 10.1080/09273940490912443 |
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We evaluated the incidence of ocular manifestations of HIV infection since the introduction of HAART. Methods: Between January 1996 and December 2002, we examined 539 HIV-infected patients in our hospital. Follow-up of the patients was performed in case of ophthalmologic symptoms, regardless of current immunologic status, or for screening. Results: A total of 217 patients (40.3%) had HIV-associated eye disease. Of these patients, 42.0% had no eye symptoms. Fifty-eight (10.8%) of the 539 patients had cytomegalovirus (CMV) retinitis, most of whom had CMV retinitis before receiving HAART. Four patients developed immune-recovery uveitis. A total of 145 patients (26.9%) had HIV-related microangiopathy and 96 (17.8%) had dry-eye syndrome. Conclusion: The introduction of HAART had a major impact on the medical history of patients with HIV-related eye disease with improved survival time and decreased morbidity.</description><identifier>ISSN: 0927-3948</identifier><identifier>EISSN: 1744-5078</identifier><identifier>DOI: 10.1080/09273940490912443</identifier><identifier>PMID: 16019681</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Acquired immunodeficiency syndrome (AIDS) ; Adolescent ; Adult ; Aged ; AIDS-Related Opportunistic Infections - drug therapy ; AIDS-Related Opportunistic Infections - epidemiology ; AIDS-Related Opportunistic Infections - immunology ; Anti-HIV Agents - therapeutic use ; Antiretroviral Therapy, Highly Active ; Austria - epidemiology ; CD4 Lymphocyte Count ; cytomegalovirus (CMV) retinitis ; Cytomegalovirus Retinitis - drug therapy ; Cytomegalovirus Retinitis - epidemiology ; Cytomegalovirus Retinitis - immunology ; Female ; Follow-Up Studies ; highly active antiretroviral therapy (HAART) ; HIV infection ; HIV-1 - genetics ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; RNA, Viral - genetics ; Treatment Outcome</subject><ispartof>Ocular immunology and inflammation, 2005-04, Vol.13 (2-3), p.213-218</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-8a01c36752fb63e9753b0829d1739a302bea0e5cf2c7b30fab2c365b0f4c6d473</citedby><cites>FETCH-LOGICAL-c404t-8a01c36752fb63e9753b0829d1739a302bea0e5cf2c7b30fab2c365b0f4c6d473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09273940490912443$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09273940490912443$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,59624,59730,60413,60519,61198,61233,61379,61414</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16019681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kahraman, Günal</creatorcontrib><creatorcontrib>Krepler, Katharina</creatorcontrib><creatorcontrib>Franz, Carmen</creatorcontrib><creatorcontrib>Ries, Eva</creatorcontrib><creatorcontrib>Maar, Noemi</creatorcontrib><creatorcontrib>Wedrich, Andreas</creatorcontrib><creatorcontrib>Rieger, Armin</creatorcontrib><creatorcontrib>Dejaco-Ruhswurm, Irene</creatorcontrib><title>Seven Years of HAART Impact on Ophthalmic Management of HIV-Infected Patients</title><title>Ocular immunology and inflammation</title><addtitle>Ocul Immunol Inflamm</addtitle><description>Purpose: The widespread use of highly active antiretroviral therapy (HAART) has changed the clinical picture of HIV-associated eye disease. We evaluated the incidence of ocular manifestations of HIV infection since the introduction of HAART. Methods: Between January 1996 and December 2002, we examined 539 HIV-infected patients in our hospital. Follow-up of the patients was performed in case of ophthalmologic symptoms, regardless of current immunologic status, or for screening. Results: A total of 217 patients (40.3%) had HIV-associated eye disease. Of these patients, 42.0% had no eye symptoms. Fifty-eight (10.8%) of the 539 patients had cytomegalovirus (CMV) retinitis, most of whom had CMV retinitis before receiving HAART. Four patients developed immune-recovery uveitis. A total of 145 patients (26.9%) had HIV-related microangiopathy and 96 (17.8%) had dry-eye syndrome. Conclusion: The introduction of HAART had a major impact on the medical history of patients with HIV-related eye disease with improved survival time and decreased morbidity.</description><subject>Acquired immunodeficiency syndrome (AIDS)</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>AIDS-Related Opportunistic Infections - epidemiology</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Austria - epidemiology</subject><subject>CD4 Lymphocyte Count</subject><subject>cytomegalovirus (CMV) retinitis</subject><subject>Cytomegalovirus Retinitis - drug therapy</subject><subject>Cytomegalovirus Retinitis - epidemiology</subject><subject>Cytomegalovirus Retinitis - immunology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>highly active antiretroviral therapy (HAART)</subject><subject>HIV infection</subject><subject>HIV-1 - genetics</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>RNA, Viral - genetics</subject><subject>Treatment Outcome</subject><issn>0927-3948</issn><issn>1744-5078</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1rGzEQxUVIaNykf0AuZU-5bTta7SfJxYSmMSQk5KPQk5jVjuo1u5IrySn-7yvXhhICPg3M_N7jzWPsjMMXDjV8hSarRJND3kDDszwXB2zCqzxPC6jqQzbZ3NMI1Mfso_cLgEg2_AM75iXwpqz5hN090SuZ5Ceh84nVyc10-viczMYlqpBYk9wv52GOw9ir5A4N_qKRTPgHzn6kM6NJBeqSBwx93PtTdqRx8PRpN0_Yy_W356ub9Pb---xqepuqGDakNQJXoqyKTLeloKYqRAt11nQ8voMCspYQqFA6U1UrQGObRbxoQeeq7PJKnLDzre_S2d8r8kGOvVc0DGjIrrwsaxB1xYsI8i2onPXekZZL14_o1pKD3HQo33UYNZ935qt2pO6_YldaBC63QG-0dSP-sW7oZMD1YJ12aFTvpdjnf_FGPiccwlyhI7mwK2dicXvS_QUOko-c</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Kahraman, Günal</creator><creator>Krepler, Katharina</creator><creator>Franz, Carmen</creator><creator>Ries, Eva</creator><creator>Maar, Noemi</creator><creator>Wedrich, Andreas</creator><creator>Rieger, Armin</creator><creator>Dejaco-Ruhswurm, Irene</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Seven Years of HAART Impact on Ophthalmic Management of HIV-Infected Patients</title><author>Kahraman, Günal ; Krepler, Katharina ; Franz, Carmen ; Ries, Eva ; Maar, Noemi ; Wedrich, Andreas ; Rieger, Armin ; Dejaco-Ruhswurm, Irene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-8a01c36752fb63e9753b0829d1739a302bea0e5cf2c7b30fab2c365b0f4c6d473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acquired immunodeficiency syndrome (AIDS)</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS-Related Opportunistic Infections - drug therapy</topic><topic>AIDS-Related Opportunistic Infections - epidemiology</topic><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Austria - epidemiology</topic><topic>CD4 Lymphocyte Count</topic><topic>cytomegalovirus (CMV) retinitis</topic><topic>Cytomegalovirus Retinitis - drug therapy</topic><topic>Cytomegalovirus Retinitis - epidemiology</topic><topic>Cytomegalovirus Retinitis - immunology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>highly active antiretroviral therapy (HAART)</topic><topic>HIV infection</topic><topic>HIV-1 - genetics</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>RNA, Viral - genetics</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kahraman, Günal</creatorcontrib><creatorcontrib>Krepler, Katharina</creatorcontrib><creatorcontrib>Franz, Carmen</creatorcontrib><creatorcontrib>Ries, Eva</creatorcontrib><creatorcontrib>Maar, Noemi</creatorcontrib><creatorcontrib>Wedrich, Andreas</creatorcontrib><creatorcontrib>Rieger, Armin</creatorcontrib><creatorcontrib>Dejaco-Ruhswurm, Irene</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ocular immunology and inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kahraman, Günal</au><au>Krepler, Katharina</au><au>Franz, Carmen</au><au>Ries, Eva</au><au>Maar, Noemi</au><au>Wedrich, Andreas</au><au>Rieger, Armin</au><au>Dejaco-Ruhswurm, Irene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seven Years of HAART Impact on Ophthalmic Management of HIV-Infected Patients</atitle><jtitle>Ocular immunology and inflammation</jtitle><addtitle>Ocul Immunol Inflamm</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>13</volume><issue>2-3</issue><spage>213</spage><epage>218</epage><pages>213-218</pages><issn>0927-3948</issn><eissn>1744-5078</eissn><abstract>Purpose: The widespread use of highly active antiretroviral therapy (HAART) has changed the clinical picture of HIV-associated eye disease. We evaluated the incidence of ocular manifestations of HIV infection since the introduction of HAART. Methods: Between January 1996 and December 2002, we examined 539 HIV-infected patients in our hospital. Follow-up of the patients was performed in case of ophthalmologic symptoms, regardless of current immunologic status, or for screening. Results: A total of 217 patients (40.3%) had HIV-associated eye disease. Of these patients, 42.0% had no eye symptoms. Fifty-eight (10.8%) of the 539 patients had cytomegalovirus (CMV) retinitis, most of whom had CMV retinitis before receiving HAART. Four patients developed immune-recovery uveitis. A total of 145 patients (26.9%) had HIV-related microangiopathy and 96 (17.8%) had dry-eye syndrome. 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| subjects | Acquired immunodeficiency syndrome (AIDS) Adolescent Adult Aged AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - epidemiology AIDS-Related Opportunistic Infections - immunology Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active Austria - epidemiology CD4 Lymphocyte Count cytomegalovirus (CMV) retinitis Cytomegalovirus Retinitis - drug therapy Cytomegalovirus Retinitis - epidemiology Cytomegalovirus Retinitis - immunology Female Follow-Up Studies highly active antiretroviral therapy (HAART) HIV infection HIV-1 - genetics Humans Incidence Male Middle Aged Retrospective Studies RNA, Viral - genetics Treatment Outcome |
| title | Seven Years of HAART Impact on Ophthalmic Management of HIV-Infected Patients |
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