Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview
The discovery of a second receptor for prostaglandin D2, chemoattractant receptor-homologous molecule expressed on T helper type 2 (CRTH2), has revived significant efforts into the development of small-molecule antagonists for allergic diseases as the receptor is predominantly expressed on cells suc...
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| Veröffentlicht in: | Expert opinion on investigational drugs 2005-07, Vol.14 (7), p.769-773 |
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| container_title | Expert opinion on investigational drugs |
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| creator | Ly, Tai Wei Bacon, Kevin B |
| description | The discovery of a second receptor for prostaglandin D2, chemoattractant receptor-homologous molecule expressed on T helper type 2 (CRTH2), has revived significant efforts into the development of small-molecule antagonists for allergic diseases as the receptor is predominantly expressed on cells such as eosinophils, TH2 cells and basophils, which are major pro-inflammatory cells in diseases such as asthma and allergic rhinitis. This brief review serves to illustrate current patent literature focusing on the similarities and differences of an ever-growing number of CRTH2 antagonists emerging from corporate laboratories. |
| doi_str_mv | 10.1517/13543784.14.7.769 |
| format | Article |
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This brief review serves to illustrate current patent literature focusing on the similarities and differences of an ever-growing number of CRTH2 antagonists emerging from corporate laboratories.</description><subject>allergy</subject><subject>Animals</subject><subject>asthma</subject><subject>carboxylic acid</subject><subject>CRTH2</subject><subject>DP receptor</subject><subject>Humans</subject><subject>Hypersensitivity - drug therapy</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - pathology</subject><subject>indoles</subject><subject>Inflammation Mediators - antagonists & inhibitors</subject><subject>Inflammation Mediators - physiology</subject><subject>Prostaglandin Antagonists - pharmacology</subject><subject>Prostaglandin Antagonists - therapeutic use</subject><subject>prostaglandin D2</subject><subject>ramatroban</subject><subject>Receptors, Immunologic - antagonists & inhibitors</subject><subject>Receptors, Immunologic - physiology</subject><subject>Receptors, Prostaglandin - antagonists & inhibitors</subject><subject>Receptors, Prostaglandin - physiology</subject><issn>1354-3784</issn><issn>1744-7658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LHTEYRoNYqtX-ADclK3dzm0yS-WjdlEtbC0KhWuguvCZvvCPJRJOM4r9v5N5SurGrBHLOQziEnHC24or377lQUvSDXHG56ld9N-6RQ95L2fSdGvbrvb43z8ABeZPzLWMtG5V4TQ54x9pWdd0h-XUZwPsmRI9m8UjXP67OWwpzgZs4T7lk6mKiZYO0JIQScC40OlodTDeTodPsPIQAZYrzh-rR-IDpYcLHY_LKgc_4dncekZ9fPl-tz5uL71-_rT9dNEYKVRorHUrjcBzs4EwnRsd4i1J2Iygl7WBbh8bK8Xrgo-tHZlmLwCUoroywTIkjcrrdvUvxfsFcdJiyQe9hxrhk3Q1MDLXSf8G2crw2qSDfgibFnBM6fZemAOlJc6afu-s_3TWXute1e3Xe7caX64D2r7ELXYGzLVCDxRTgMSZvdYEnH5NLMJspa_HS_sd_9A2CLxsDCfVtXNJcC7_wu99YPqTF</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Ly, Tai Wei</creator><creator>Bacon, Kevin B</creator><general>Ashley Publications Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview</title><author>Ly, Tai Wei ; Bacon, Kevin B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-d4fe4cfe98d8fc639f012e4469a554d8d2fecd49b819f790d02ea14a515c3d053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>allergy</topic><topic>Animals</topic><topic>asthma</topic><topic>carboxylic acid</topic><topic>CRTH2</topic><topic>DP receptor</topic><topic>Humans</topic><topic>Hypersensitivity - drug therapy</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - pathology</topic><topic>indoles</topic><topic>Inflammation Mediators - antagonists & inhibitors</topic><topic>Inflammation Mediators - physiology</topic><topic>Prostaglandin Antagonists - pharmacology</topic><topic>Prostaglandin Antagonists - therapeutic use</topic><topic>prostaglandin D2</topic><topic>ramatroban</topic><topic>Receptors, Immunologic - antagonists & inhibitors</topic><topic>Receptors, Immunologic - physiology</topic><topic>Receptors, Prostaglandin - antagonists & inhibitors</topic><topic>Receptors, Prostaglandin - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ly, Tai Wei</creatorcontrib><creatorcontrib>Bacon, Kevin B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Expert opinion on investigational drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ly, Tai Wei</au><au>Bacon, Kevin B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview</atitle><jtitle>Expert opinion on investigational drugs</jtitle><addtitle>Expert Opin Investig Drugs</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>14</volume><issue>7</issue><spage>769</spage><epage>773</epage><pages>769-773</pages><issn>1354-3784</issn><eissn>1744-7658</eissn><abstract>The discovery of a second receptor for prostaglandin D2, chemoattractant receptor-homologous molecule expressed on T helper type 2 (CRTH2), has revived significant efforts into the development of small-molecule antagonists for allergic diseases as the receptor is predominantly expressed on cells such as eosinophils, TH2 cells and basophils, which are major pro-inflammatory cells in diseases such as asthma and allergic rhinitis. 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| fulltext | fulltext |
| identifier | ISSN: 1354-3784 |
| ispartof | Expert opinion on investigational drugs, 2005-07, Vol.14 (7), p.769-773 |
| issn | 1354-3784 1744-7658 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68038437 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | allergy Animals asthma carboxylic acid CRTH2 DP receptor Humans Hypersensitivity - drug therapy Hypersensitivity - immunology Hypersensitivity - pathology indoles Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - physiology Prostaglandin Antagonists - pharmacology Prostaglandin Antagonists - therapeutic use prostaglandin D2 ramatroban Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - physiology Receptors, Prostaglandin - antagonists & inhibitors Receptors, Prostaglandin - physiology |
| title | Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview |
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