Trypanosoma cruzi Proteome
To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi. Peptides mapping to 2784 proteins in 1168 protein groups from the annotated T. cruzi genome were identif...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2005-07, Vol.309 (5733), p.473-476 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 476 |
|---|---|
| container_issue | 5733 |
| container_start_page | 473 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 309 |
| creator | Atwood, J. A Weatherly, D. B Minning, T. A Bundy, B Cavola, C Opperdoes, F. R Orlando, R Tarleton, R. L |
| description | To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi. Peptides mapping to 2784 proteins in 1168 protein groups from the annotated T. cruzi genome were identified across the four life-cycle stages. Protein products were identified from >1000 genes annotated as "hypothetical" in the sequenced genome, including members of a newly defined gene family annotated as mucin-associated surface proteins. The four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes. |
| doi_str_mv | 10.1126/science.1110289 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68037615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A134675164</galeid><jstor_id>3842238</jstor_id><sourcerecordid>A134675164</sourcerecordid><originalsourceid>FETCH-LOGICAL-c639t-65aed9519935860b61fdeb85271d7743e655d135be3e0a65c239bd5d9d8688283</originalsourceid><addsrcrecordid>eNqN0lGL1DAQB_AiireePgsieggKPvQuk2zS5PFu0fVgcYW78zWk6bR0aZs1acG7T2-WFnVlwSUPJZ3fDC3zT5KXQM4BqLgItsbOYrwAoVI9SmZAFE8VJexxMiOEiVSSjJ8kz0LYEBJrij1NTkAQSjImZsmrW3-_NZ0LrjVn1g8P9dk373p0LT5PnpSmCfhiep4md58_3S6-pKv18npxuUqtYKpPBTdYKA5KMS4FyQWUBeaS0wyKLJszFJwXwHiODIkR3FKm8oIXqpBCSirZafJhnLv17seAoddtHSw2jenQDUELSVgmgP8XQiYlMFARvvsHbtzgu_gTmgITZE6liCgdUWUa1HVXut4bW2GH3jSuw7KOry-BzUXGQcyjPz_g4ymwre3Bho97DdH0-LOvzBCCvr75erxdfz_eXi2PtnK52rfpIWtd02CFOu58sd73F6O33oXgsdRbX7fG32sgepdOPaVTT-mMHW-mvQx5i8UfP8UxgvcTMMGapvSms3X4yykuSLYb9Hp0m9A7_7vO5JxStkvU27FcGqdN5eOIuxtKgBEgED-ds18_FfdI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213604286</pqid></control><display><type>article</type><title>Trypanosoma cruzi Proteome</title><source>MEDLINE</source><source>Science Magazine</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Atwood, J. A ; Weatherly, D. B ; Minning, T. A ; Bundy, B ; Cavola, C ; Opperdoes, F. R ; Orlando, R ; Tarleton, R. L</creator><creatorcontrib>Atwood, J. A ; Weatherly, D. B ; Minning, T. A ; Bundy, B ; Cavola, C ; Opperdoes, F. R ; Orlando, R ; Tarleton, R. L</creatorcontrib><description>To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi. Peptides mapping to 2784 proteins in 1168 protein groups from the annotated T. cruzi genome were identified across the four life-cycle stages. Protein products were identified from >1000 genes annotated as "hypothetical" in the sequenced genome, including members of a newly defined gene family annotated as mucin-associated surface proteins. The four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1110289</identifier><identifier>PMID: 16020736</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Adaptation, Physiological ; Amastigotes ; Analysis ; Animals ; Antigens, Protozoan - analysis ; Biochemistry ; Biochemistry. Physiology. Immunology. Molecular biology ; Biological and medical sciences ; Causes of ; Chromatography, Liquid ; Computational Biology ; Databases, Genetic ; DNA ; Energy Metabolism ; Enzymes ; Enzymes - genetics ; Enzymes - metabolism ; Epimastigotes ; Fundamental and applied biological sciences. Psychology ; Genes, Protozoan ; Genetic aspects ; Genome, Protozoan ; Genomes ; Genomics ; Glycoproteins - analysis ; Glycoproteins - genetics ; Health aspects ; Histidine - metabolism ; Insect carriers of disease ; Insect vectors ; Insects as carriers of disease ; Life Cycle Stages ; Life cycles ; Mass Spectrometry ; Membrane Proteins - analysis ; Membrane Proteins - genetics ; Mucins - analysis ; Multigene Family ; Neuraminidase - analysis ; Neuraminidase - genetics ; Parasite hosts ; Parasites ; Peptides - analysis ; Protein Transport ; Proteins ; Proteome ; Proteomes ; Proteomics ; Protozoa ; Protozoan Proteins - analysis ; Protozoan Proteins - genetics ; Protozoan Proteins - metabolism ; Protozoans ; Tropical diseases ; Trypanosoma cruzi ; Trypanosoma cruzi - chemistry ; Trypanosoma cruzi - genetics ; Trypanosoma cruzi - growth & development ; Trypanosoma cruzi - metabolism ; Trypanosomatina ; Trypomastigotes</subject><ispartof>Science (American Association for the Advancement of Science), 2005-07, Vol.309 (5733), p.473-476</ispartof><rights>Copyright 2005 American Association for the Advancement of Science</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2005 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 15, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c639t-65aed9519935860b61fdeb85271d7743e655d135be3e0a65c239bd5d9d8688283</citedby><cites>FETCH-LOGICAL-c639t-65aed9519935860b61fdeb85271d7743e655d135be3e0a65c239bd5d9d8688283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3842238$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3842238$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16956079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16020736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atwood, J. A</creatorcontrib><creatorcontrib>Weatherly, D. B</creatorcontrib><creatorcontrib>Minning, T. A</creatorcontrib><creatorcontrib>Bundy, B</creatorcontrib><creatorcontrib>Cavola, C</creatorcontrib><creatorcontrib>Opperdoes, F. R</creatorcontrib><creatorcontrib>Orlando, R</creatorcontrib><creatorcontrib>Tarleton, R. L</creatorcontrib><title>Trypanosoma cruzi Proteome</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi. Peptides mapping to 2784 proteins in 1168 protein groups from the annotated T. cruzi genome were identified across the four life-cycle stages. Protein products were identified from >1000 genes annotated as "hypothetical" in the sequenced genome, including members of a newly defined gene family annotated as mucin-associated surface proteins. The four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes.</description><subject>Adaptation, Physiological</subject><subject>Amastigotes</subject><subject>Analysis</subject><subject>Animals</subject><subject>Antigens, Protozoan - analysis</subject><subject>Biochemistry</subject><subject>Biochemistry. Physiology. Immunology. Molecular biology</subject><subject>Biological and medical sciences</subject><subject>Causes of</subject><subject>Chromatography, Liquid</subject><subject>Computational Biology</subject><subject>Databases, Genetic</subject><subject>DNA</subject><subject>Energy Metabolism</subject><subject>Enzymes</subject><subject>Enzymes - genetics</subject><subject>Enzymes - metabolism</subject><subject>Epimastigotes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Protozoan</subject><subject>Genetic aspects</subject><subject>Genome, Protozoan</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Glycoproteins - analysis</subject><subject>Glycoproteins - genetics</subject><subject>Health aspects</subject><subject>Histidine - metabolism</subject><subject>Insect carriers of disease</subject><subject>Insect vectors</subject><subject>Insects as carriers of disease</subject><subject>Life Cycle Stages</subject><subject>Life cycles</subject><subject>Mass Spectrometry</subject><subject>Membrane Proteins - analysis</subject><subject>Membrane Proteins - genetics</subject><subject>Mucins - analysis</subject><subject>Multigene Family</subject><subject>Neuraminidase - analysis</subject><subject>Neuraminidase - genetics</subject><subject>Parasite hosts</subject><subject>Parasites</subject><subject>Peptides - analysis</subject><subject>Protein Transport</subject><subject>Proteins</subject><subject>Proteome</subject><subject>Proteomes</subject><subject>Proteomics</subject><subject>Protozoa</subject><subject>Protozoan Proteins - analysis</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - metabolism</subject><subject>Protozoans</subject><subject>Tropical diseases</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - chemistry</subject><subject>Trypanosoma cruzi - genetics</subject><subject>Trypanosoma cruzi - growth & development</subject><subject>Trypanosoma cruzi - metabolism</subject><subject>Trypanosomatina</subject><subject>Trypomastigotes</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0lGL1DAQB_AiireePgsieggKPvQuk2zS5PFu0fVgcYW78zWk6bR0aZs1acG7T2-WFnVlwSUPJZ3fDC3zT5KXQM4BqLgItsbOYrwAoVI9SmZAFE8VJexxMiOEiVSSjJ8kz0LYEBJrij1NTkAQSjImZsmrW3-_NZ0LrjVn1g8P9dk373p0LT5PnpSmCfhiep4md58_3S6-pKv18npxuUqtYKpPBTdYKA5KMS4FyQWUBeaS0wyKLJszFJwXwHiODIkR3FKm8oIXqpBCSirZafJhnLv17seAoddtHSw2jenQDUELSVgmgP8XQiYlMFARvvsHbtzgu_gTmgITZE6liCgdUWUa1HVXut4bW2GH3jSuw7KOry-BzUXGQcyjPz_g4ymwre3Bho97DdH0-LOvzBCCvr75erxdfz_eXi2PtnK52rfpIWtd02CFOu58sd73F6O33oXgsdRbX7fG32sgepdOPaVTT-mMHW-mvQx5i8UfP8UxgvcTMMGapvSms3X4yykuSLYb9Hp0m9A7_7vO5JxStkvU27FcGqdN5eOIuxtKgBEgED-ds18_FfdI</recordid><startdate>20050715</startdate><enddate>20050715</enddate><creator>Atwood, J. A</creator><creator>Weatherly, D. B</creator><creator>Minning, T. A</creator><creator>Bundy, B</creator><creator>Cavola, C</creator><creator>Opperdoes, F. R</creator><creator>Orlando, R</creator><creator>Tarleton, R. L</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050715</creationdate><title>Trypanosoma cruzi Proteome</title><author>Atwood, J. A ; Weatherly, D. B ; Minning, T. A ; Bundy, B ; Cavola, C ; Opperdoes, F. R ; Orlando, R ; Tarleton, R. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c639t-65aed9519935860b61fdeb85271d7743e655d135be3e0a65c239bd5d9d8688283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adaptation, Physiological</topic><topic>Amastigotes</topic><topic>Analysis</topic><topic>Animals</topic><topic>Antigens, Protozoan - analysis</topic><topic>Biochemistry</topic><topic>Biochemistry. Physiology. Immunology. Molecular biology</topic><topic>Biological and medical sciences</topic><topic>Causes of</topic><topic>Chromatography, Liquid</topic><topic>Computational Biology</topic><topic>Databases, Genetic</topic><topic>DNA</topic><topic>Energy Metabolism</topic><topic>Enzymes</topic><topic>Enzymes - genetics</topic><topic>Enzymes - metabolism</topic><topic>Epimastigotes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Protozoan</topic><topic>Genetic aspects</topic><topic>Genome, Protozoan</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Glycoproteins - analysis</topic><topic>Glycoproteins - genetics</topic><topic>Health aspects</topic><topic>Histidine - metabolism</topic><topic>Insect carriers of disease</topic><topic>Insect vectors</topic><topic>Insects as carriers of disease</topic><topic>Life Cycle Stages</topic><topic>Life cycles</topic><topic>Mass Spectrometry</topic><topic>Membrane Proteins - analysis</topic><topic>Membrane Proteins - genetics</topic><topic>Mucins - analysis</topic><topic>Multigene Family</topic><topic>Neuraminidase - analysis</topic><topic>Neuraminidase - genetics</topic><topic>Parasite hosts</topic><topic>Parasites</topic><topic>Peptides - analysis</topic><topic>Protein Transport</topic><topic>Proteins</topic><topic>Proteome</topic><topic>Proteomes</topic><topic>Proteomics</topic><topic>Protozoa</topic><topic>Protozoan Proteins - analysis</topic><topic>Protozoan Proteins - genetics</topic><topic>Protozoan Proteins - metabolism</topic><topic>Protozoans</topic><topic>Tropical diseases</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - chemistry</topic><topic>Trypanosoma cruzi - genetics</topic><topic>Trypanosoma cruzi - growth & development</topic><topic>Trypanosoma cruzi - metabolism</topic><topic>Trypanosomatina</topic><topic>Trypomastigotes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atwood, J. A</creatorcontrib><creatorcontrib>Weatherly, D. B</creatorcontrib><creatorcontrib>Minning, T. A</creatorcontrib><creatorcontrib>Bundy, B</creatorcontrib><creatorcontrib>Cavola, C</creatorcontrib><creatorcontrib>Opperdoes, F. R</creatorcontrib><creatorcontrib>Orlando, R</creatorcontrib><creatorcontrib>Tarleton, R. L</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atwood, J. A</au><au>Weatherly, D. B</au><au>Minning, T. A</au><au>Bundy, B</au><au>Cavola, C</au><au>Opperdoes, F. R</au><au>Orlando, R</au><au>Tarleton, R. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trypanosoma cruzi Proteome</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2005-07-15</date><risdate>2005</risdate><volume>309</volume><issue>5733</issue><spage>473</spage><epage>476</epage><pages>473-476</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi. Peptides mapping to 2784 proteins in 1168 protein groups from the annotated T. cruzi genome were identified across the four life-cycle stages. Protein products were identified from >1000 genes annotated as "hypothetical" in the sequenced genome, including members of a newly defined gene family annotated as mucin-associated surface proteins. The four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>16020736</pmid><doi>10.1126/science.1110289</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2005-07, Vol.309 (5733), p.473-476 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68037615 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Adaptation, Physiological Amastigotes Analysis Animals Antigens, Protozoan - analysis Biochemistry Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Causes of Chromatography, Liquid Computational Biology Databases, Genetic DNA Energy Metabolism Enzymes Enzymes - genetics Enzymes - metabolism Epimastigotes Fundamental and applied biological sciences. Psychology Genes, Protozoan Genetic aspects Genome, Protozoan Genomes Genomics Glycoproteins - analysis Glycoproteins - genetics Health aspects Histidine - metabolism Insect carriers of disease Insect vectors Insects as carriers of disease Life Cycle Stages Life cycles Mass Spectrometry Membrane Proteins - analysis Membrane Proteins - genetics Mucins - analysis Multigene Family Neuraminidase - analysis Neuraminidase - genetics Parasite hosts Parasites Peptides - analysis Protein Transport Proteins Proteome Proteomes Proteomics Protozoa Protozoan Proteins - analysis Protozoan Proteins - genetics Protozoan Proteins - metabolism Protozoans Tropical diseases Trypanosoma cruzi Trypanosoma cruzi - chemistry Trypanosoma cruzi - genetics Trypanosoma cruzi - growth & development Trypanosoma cruzi - metabolism Trypanosomatina Trypomastigotes |
| title | Trypanosoma cruzi Proteome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T05%3A39%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trypanosoma%20cruzi%20Proteome&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Atwood,%20J.%20A&rft.date=2005-07-15&rft.volume=309&rft.issue=5733&rft.spage=473&rft.epage=476&rft.pages=473-476&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1110289&rft_dat=%3Cgale_proqu%3EA134675164%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213604286&rft_id=info:pmid/16020736&rft_galeid=A134675164&rft_jstor_id=3842238&rfr_iscdi=true |