Induction and activity-dependent reversal of persistent LTP and LTD in lateral perforant path synapses in vivo

The reversibility of long-term potentiation (LTP) and heterosynaptic long-term depression (LTD) lasting weeks was examined in the lateral perforant path of freely moving adult Sprague–Dawley rats. LTP lasting weeks was rapidly reversed within minutes by high-frequency heterosynaptic stimulation of t...

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Veröffentlicht in:	Neurobiology of learning and memory 2006-07, Vol.86 (1), p.82-90
Hauptverfasser:	Abraham, W.C., Mason-Parker, S.E., Irvine, G.I., Logan, B., Gill, A.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anatomical correlates of behavior Animal Animals Behavioral psychophysiology Biological and medical sciences Brain Dentate gyrus Dentate Gyrus - cytology Dentate Gyrus - physiology Electric Stimulation Enriched environment Environment Fundamental and applied biological sciences. Psychology Hippocampus Learning Learning. Memory Long-Term Potentiation - physiology Long-Term Synaptic Depression - physiology Male Memory Neurology NMDA receptors Perforant Pathway - cytology Perforant Pathway - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - physiology Rodents Statistics, Nonparametric Synapses - physiology Synaptic plasticity Time Factors Watermaze
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