The Mechanical Properties of Infrainguinal Vascular Bypass Grafts: Their Role in Influencing Patency
When autologous vein is unavailable, prosthetic graft materials, particularly expanded polytetrafluoroethylene are used for peripheral arterial revascularisation. Poor long term patency of prosthetic materials is due to distal anastomotic intimal hyperplasia. Intimal hyperplasia is directly linked t...
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| Veröffentlicht in: | European journal of vascular and endovascular surgery 2006-06, Vol.31 (6), p.627-636 |
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| container_title | European journal of vascular and endovascular surgery |
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| creator | Sarkar, S. Salacinski, H.J. Hamilton, G. Seifalian, A.M. |
| description | When autologous vein is unavailable, prosthetic graft materials, particularly expanded polytetrafluoroethylene are used for peripheral arterial revascularisation. Poor long term patency of prosthetic materials is due to distal anastomotic intimal hyperplasia. Intimal hyperplasia is directly linked to shear stress abnormalities at the vessel wall. Compliance and calibre mismatch between native vessel and graft, as well as anastomotic line stress concentration contribute towards unnatural wall shear stress. High porosity reduces graft compliance by causing fibrovascular infiltration, whereas low porosity discourages the development of an endothelial lining and hence effective antithrombogenicity. Therefore, consideration of mechanical properties is necessary in graft development. Current research into synthetic vascular grafts concentrates on simulating the mechanical properties of native arteries and tissue engineering aims to construct a new biological arterial conduit. |
| doi_str_mv | 10.1016/j.ejvs.2006.01.006 |
| format | Article |
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Poor long term patency of prosthetic materials is due to distal anastomotic intimal hyperplasia. Intimal hyperplasia is directly linked to shear stress abnormalities at the vessel wall. Compliance and calibre mismatch between native vessel and graft, as well as anastomotic line stress concentration contribute towards unnatural wall shear stress. High porosity reduces graft compliance by causing fibrovascular infiltration, whereas low porosity discourages the development of an endothelial lining and hence effective antithrombogenicity. Therefore, consideration of mechanical properties is necessary in graft development. 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Poor long term patency of prosthetic materials is due to distal anastomotic intimal hyperplasia. Intimal hyperplasia is directly linked to shear stress abnormalities at the vessel wall. Compliance and calibre mismatch between native vessel and graft, as well as anastomotic line stress concentration contribute towards unnatural wall shear stress. High porosity reduces graft compliance by causing fibrovascular infiltration, whereas low porosity discourages the development of an endothelial lining and hence effective antithrombogenicity. Therefore, consideration of mechanical properties is necessary in graft development. Current research into synthetic vascular grafts concentrates on simulating the mechanical properties of native arteries and tissue engineering aims to construct a new biological arterial conduit.</description><subject>Anastomosis</subject><subject>Anastomosis, Surgical</subject><subject>Animals</subject><subject>Arteries - pathology</subject><subject>Arteries - surgery</subject><subject>Biomechanical Phenomena</subject><subject>Blood Flow Velocity</subject><subject>Blood Vessel Prosthesis</subject><subject>Compliance</subject><subject>Compliance mismatch</subject><subject>Graft caliber</subject><subject>Graft Occlusion, Vascular - prevention & control</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Infrainguinal bypass</subject><subject>Intimal hyperplasia</subject><subject>Lower Extremity - blood supply</subject><subject>Polyethylene Terephthalates</subject><subject>Polytetrafluoroethylene</subject><subject>Polyurethane</subject><subject>Polyurethanes</subject><subject>Porosity</subject><subject>Pressure</subject><subject>Prosthesis Design</subject><subject>Pulsatile Flow</subject><subject>Tissue Engineering</subject><subject>Tunica Intima - pathology</subject><subject>Vascular graft</subject><subject>Vascular Patency</subject><subject>Vessel wall mechanics</subject><issn>1078-5884</issn><issn>1532-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UEtLAzEYDKL4_gMeJCdvu-bRpFvxokVrQVFEvYavybc2Zbtbk91C_71ZWvDmaQbmATOEXHCWc8b19SLHxTrmgjGdM54n2CPHXEmRCa7VfuJsWGSqKAZH5CTGBWNMcakOyVGSuZRDfUzcxxzpC9o51N5CRd9Cs8LQeoy0Kem0LgP4-rvzddK-INqugkDvNyuIkU4ClG28oanCB_reVEh93WeqDmubYvQN2sQ2Z-SghCri-Q5Pyefjw8f4KXt-nUzHd8-ZlaOizbQaWQXCOY4cFHNKAZZOSKuZ0AOhGXBISjEbWdAMsZBqpAezgSiGToEV8pRcbXtXofnpMLZm6aPFqoIamy4aXTA5FLo3iq3RhibGgKVZBb-EsDGcmf5bszD9t6b_1jBuEqTQ5a69my3R_UV2ZybD7daAaePaYzDR-rQfnQ9oW-Ma_1__L29vi2M</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Sarkar, S.</creator><creator>Salacinski, H.J.</creator><creator>Hamilton, G.</creator><creator>Seifalian, A.M.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>The Mechanical Properties of Infrainguinal Vascular Bypass Grafts: Their Role in Influencing Patency</title><author>Sarkar, S. ; 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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Anastomosis Anastomosis, Surgical Animals Arteries - pathology Arteries - surgery Biomechanical Phenomena Blood Flow Velocity Blood Vessel Prosthesis Compliance Compliance mismatch Graft caliber Graft Occlusion, Vascular - prevention & control Humans Hyperplasia Infrainguinal bypass Intimal hyperplasia Lower Extremity - blood supply Polyethylene Terephthalates Polytetrafluoroethylene Polyurethane Polyurethanes Porosity Pressure Prosthesis Design Pulsatile Flow Tissue Engineering Tunica Intima - pathology Vascular graft Vascular Patency Vessel wall mechanics |
| title | The Mechanical Properties of Infrainguinal Vascular Bypass Grafts: Their Role in Influencing Patency |
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