Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity
After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a...
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| Veröffentlicht in: | International journal of hyperthermia 2005-05, Vol.21 (3), p.247-257 |
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| container_title | International journal of hyperthermia |
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| creator | Kuang, M. Liu, S. Q. Saijo, K. Uchimura, E. Huang, L. Leong, K.W. Lu, M. D. Huang, J. F. Ohno, T. |
| description | After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use. |
| doi_str_mv | 10.1080/02656730500052027 |
| format | Article |
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Q. ; Saijo, K. ; Uchimura, E. ; Huang, L. ; Leong, K.W. ; Lu, M. D. ; Huang, J. F. ; Ohno, T.</creator><creatorcontrib>Kuang, M. ; Liu, S. Q. ; Saijo, K. ; Uchimura, E. ; Huang, L. ; Leong, K.W. ; Lu, M. D. ; Huang, J. F. ; Ohno, T.</creatorcontrib><description>After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use.</description><identifier>ISSN: 0265-6736</identifier><identifier>EISSN: 1464-5157</identifier><identifier>DOI: 10.1080/02656730500052027</identifier><identifier>PMID: 16019851</identifier><identifier>CODEN: IJHYEQ</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Cancer Vaccines ; Carcinoma, Lewis Lung - pathology ; Carcinoma, Lewis Lung - radiotherapy ; Carcinoma, Lewis Lung - surgery ; Cardiology. Vascular system ; CD3 Complex - immunology ; Cell Line, Tumor ; Cytokine ; Electrocoagulation - methods ; Female ; Graft Rejection ; Granulocyte-Macrophage Colony-Stimulating Factor - genetics ; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology ; Humans ; immunotherapy ; in situ vaccination ; Intensive care medicine ; Interleukin-2 - genetics ; Interleukin-2 - pharmacology ; Killer Cells, Natural - immunology ; Lung Neoplasms - pathology ; Lung Neoplasms - radiotherapy ; Lung Neoplasms - surgery ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Microspheres ; microwave ; Microwaves - therapeutic use ; Neoplasm Transplantation ; Recombinant Proteins - pharmacology ; T-Lymphocytes, Cytotoxic - immunology ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Tumor Burden ; tumour coagulation</subject><ispartof>International journal of hyperthermia, 2005-05, Vol.21 (3), p.247-257</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-14a27468da5eaa7f15e28cc375fee872f0207c7c5abcc91572a2a26943dbcd453</citedby><cites>FETCH-LOGICAL-c434t-14a27468da5eaa7f15e28cc375fee872f0207c7c5abcc91572a2a26943dbcd453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/02656730500052027$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/02656730500052027$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16801879$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16019851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuang, M.</creatorcontrib><creatorcontrib>Liu, S. Q.</creatorcontrib><creatorcontrib>Saijo, K.</creatorcontrib><creatorcontrib>Uchimura, E.</creatorcontrib><creatorcontrib>Huang, L.</creatorcontrib><creatorcontrib>Leong, K.W.</creatorcontrib><creatorcontrib>Lu, M. D.</creatorcontrib><creatorcontrib>Huang, J. F.</creatorcontrib><creatorcontrib>Ohno, T.</creatorcontrib><title>Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity</title><title>International journal of hyperthermia</title><addtitle>Int J Hyperthermia</addtitle><description>After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Cancer Vaccines</subject><subject>Carcinoma, Lewis Lung - pathology</subject><subject>Carcinoma, Lewis Lung - radiotherapy</subject><subject>Carcinoma, Lewis Lung - surgery</subject><subject>Cardiology. Vascular system</subject><subject>CD3 Complex - immunology</subject><subject>Cell Line, Tumor</subject><subject>Cytokine</subject><subject>Electrocoagulation - methods</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - genetics</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology</subject><subject>Humans</subject><subject>immunotherapy</subject><subject>in situ vaccination</subject><subject>Intensive care medicine</subject><subject>Interleukin-2 - genetics</subject><subject>Interleukin-2 - pharmacology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microspheres</subject><subject>microwave</subject><subject>Microwaves - therapeutic use</subject><subject>Neoplasm Transplantation</subject><subject>Recombinant Proteins - pharmacology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Tumor Burden</subject><subject>tumour coagulation</subject><issn>0265-6736</issn><issn>1464-5157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDuPEzEURi0EYsPCD6BBbqAbsD1-TIAGrXistIgG6tGNx0O8-DH4QZSaP45DsgKEtHLhwuf7fO9B6DElzykZyAvCpJCqJ4IQIhhh6g5aUS55J6hQd9Hq8N41QJ6hBzlfN4oLpu6jMyoJXQ-CrtDPj1anuIMfBpfqY01YR_haHRQbA15czdgGnG2puCQDxZtQ8M6WLdb7Er_ZYDp_aFggFaudyS_xZZiq_h2PM15iOSQgFNslk-1Uwd38ZL2vwZb9Q3RvBpfNo9N9jr68e_v54kN39en95cWbq07znpeOcmCKy2ECYQDUTIVhg9a9ErMxg2IzYURppQVstF43AwzakWveTxs9cdGfo2fH3iXF79XkMnqbtXEOgok1j3IgvWxGG0iPYFss52TmcUnWQ9qPlIwH8-N_5lvmyam8bryZ_iROqhvw9ARA1uDmBEHb_Bc3EDqodeNeHzkb5pg87GJy01hg72K6CfW3zfHqn_jWgCtbDcmM1016aIJv2eIX41-0Rg</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Kuang, M.</creator><creator>Liu, S. Q.</creator><creator>Saijo, K.</creator><creator>Uchimura, E.</creator><creator>Huang, L.</creator><creator>Leong, K.W.</creator><creator>Lu, M. D.</creator><creator>Huang, J. F.</creator><creator>Ohno, T.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity</title><author>Kuang, M. ; Liu, S. Q. ; Saijo, K. ; Uchimura, E. ; Huang, L. ; Leong, K.W. ; Lu, M. D. ; Huang, J. F. ; Ohno, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-14a27468da5eaa7f15e28cc375fee872f0207c7c5abcc91572a2a26943dbcd453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Cancer Vaccines</topic><topic>Carcinoma, Lewis Lung - pathology</topic><topic>Carcinoma, Lewis Lung - radiotherapy</topic><topic>Carcinoma, Lewis Lung - surgery</topic><topic>Cardiology. Vascular system</topic><topic>CD3 Complex - immunology</topic><topic>Cell Line, Tumor</topic><topic>Cytokine</topic><topic>Electrocoagulation - methods</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - genetics</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology</topic><topic>Humans</topic><topic>immunotherapy</topic><topic>in situ vaccination</topic><topic>Intensive care medicine</topic><topic>Interleukin-2 - genetics</topic><topic>Interleukin-2 - pharmacology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microspheres</topic><topic>microwave</topic><topic>Microwaves - therapeutic use</topic><topic>Neoplasm Transplantation</topic><topic>Recombinant Proteins - pharmacology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Tumor Burden</topic><topic>tumour coagulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuang, M.</creatorcontrib><creatorcontrib>Liu, S. Q.</creatorcontrib><creatorcontrib>Saijo, K.</creatorcontrib><creatorcontrib>Uchimura, E.</creatorcontrib><creatorcontrib>Huang, L.</creatorcontrib><creatorcontrib>Leong, K.W.</creatorcontrib><creatorcontrib>Lu, M. D.</creatorcontrib><creatorcontrib>Huang, J. 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F.</au><au>Ohno, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity</atitle><jtitle>International journal of hyperthermia</jtitle><addtitle>Int J Hyperthermia</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>21</volume><issue>3</issue><spage>247</spage><epage>257</epage><pages>247-257</pages><issn>0265-6736</issn><eissn>1464-5157</eissn><coden>IJHYEQ</coden><abstract>After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>16019851</pmid><doi>10.1080/02656730500052027</doi><tpages>11</tpages></addata></record> |
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| ispartof | International journal of hyperthermia, 2005-05, Vol.21 (3), p.247-257 |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Cancer Vaccines Carcinoma, Lewis Lung - pathology Carcinoma, Lewis Lung - radiotherapy Carcinoma, Lewis Lung - surgery Cardiology. Vascular system CD3 Complex - immunology Cell Line, Tumor Cytokine Electrocoagulation - methods Female Graft Rejection Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans immunotherapy in situ vaccination Intensive care medicine Interleukin-2 - genetics Interleukin-2 - pharmacology Killer Cells, Natural - immunology Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Lung Neoplasms - surgery Male Medical sciences Mice Mice, Inbred C57BL Microspheres microwave Microwaves - therapeutic use Neoplasm Transplantation Recombinant Proteins - pharmacology T-Lymphocytes, Cytotoxic - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor Burden tumour coagulation |
| title | Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: Induction of potent anti-residual tumour immunity |
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