Body-Mass Index and Symptoms of Gastroesophageal Reflux in Women

Obesity is a known risk factor for gastroesophageal reflux disease. Among more than 10,000 women enrolled in the Nurses' Health Study, body-mass index was associated with symptoms of gastroesophageal reflux in both normal-weight and overweight women. Weight gain was associated with symptoms of...

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Veröffentlicht in:The New England journal of medicine 2006-06, Vol.354 (22), p.2340-2348
Hauptverfasser: Jacobson, Brian C, Somers, Samuel C, Fuchs, Charles S, Kelly, Ciarán P, Camargo, Carlos A
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container_end_page 2348
container_issue 22
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container_title The New England journal of medicine
container_volume 354
creator Jacobson, Brian C
Somers, Samuel C
Fuchs, Charles S
Kelly, Ciarán P
Camargo, Carlos A
description Obesity is a known risk factor for gastroesophageal reflux disease. Among more than 10,000 women enrolled in the Nurses' Health Study, body-mass index was associated with symptoms of gastroesophageal reflux in both normal-weight and overweight women. Weight gain was associated with symptoms of reflux, even in women with a normal body-mass index at baseline. Body-mass index was associated with symptoms of gastroesophageal reflux in both normal-weight and overweight women. Weight gain was associated with symptoms of reflux, even in women with a normal body-mass index at baseline. Gastroesophageal reflux disease, with hallmark symptoms of heartburn and acid regurgitation, 1 is a common disorder, affecting up to 60 percent of persons at some time during the course of a year and 20 to 30 percent of persons at least weekly. 2 , 3 Gastroesophageal reflux disease accounts for at least 9 million office visits to physicians in the United States each year and costs approximately $10 billion annually. 4 Frequent or severe symptoms of gastroesophageal reflux disease are associated with time lost from work, 5 impaired health-related quality of life, 6 and esophageal adenocarcinoma, 7 further emphasizing the clinical significance of this entity. Several cross-sectional . . .
doi_str_mv 10.1056/NEJMoa054391
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Gastroesophageal reflux disease, with hallmark symptoms of heartburn and acid regurgitation, 1 is a common disorder, affecting up to 60 percent of persons at some time during the course of a year and 20 to 30 percent of persons at least weekly. 2 , 3 Gastroesophageal reflux disease accounts for at least 9 million office visits to physicians in the United States each year and costs approximately $10 billion annually. 4 Frequent or severe symptoms of gastroesophageal reflux disease are associated with time lost from work, 5 impaired health-related quality of life, 6 and esophageal adenocarcinoma, 7 further emphasizing the clinical significance of this entity. 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Among more than 10,000 women enrolled in the Nurses' Health Study, body-mass index was associated with symptoms of gastroesophageal reflux in both normal-weight and overweight women. Weight gain was associated with symptoms of reflux, even in women with a normal body-mass index at baseline. Body-mass index was associated with symptoms of gastroesophageal reflux in both normal-weight and overweight women. Weight gain was associated with symptoms of reflux, even in women with a normal body-mass index at baseline. 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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine
subjects Acids
Adult
Asthma
Biological and medical sciences
Body Mass Index
Chronic obstructive pulmonary disease
Cohort Studies
Digestive system
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - etiology
General aspects
Heartburn - etiology
Humans
Lifestyles
Logistic Models
Medical sciences
Middle Aged
Multivariate Analysis
Nurses
Obesity - complications
Other diseases. Semiology
Overweight
Questionnaires
Risk Factors
Severity of Illness Index
Surveys and Questionnaires
Throat
Waist-Hip Ratio
Weight Gain
Womens health
title Body-Mass Index and Symptoms of Gastroesophageal Reflux in Women
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