A novel electroporation device for gene delivery in large animals and humans

Intramuscular injection of plasmid DNA followed by electrical stimulation (electroporation) is an efficient method for achieving therapeutic levels of encoded proteins or eliciting efficient immune responses in smaller animals such as mice and rats. Electroporation in larger animals and humans poses...

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Veröffentlicht in:	Vaccine 2006-05, Vol.24 (21), p.4667-4670
Hauptverfasser:	Tjelle, Torunn Elisabeth, Salte, Ragnar, Mathiesen, Iacob, Kjeken, Rune
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation beta-Galactosidase - genetics Deoxyribonucleic acid Design DNA DNA vaccination Efficiency Electrodes Electroporation Electroporation - instrumentation Equipment Design Gene expression Gene Transfer Techniques Genetic Therapy Green Fluorescent Proteins - genetics Humans Immunization Injection Mice Needles Pain Rats Sheep
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