New Amides of 5-Acylamino-3-Methyl-4-Isothiazolecarboxylic Acid and their Immunotropic Activity
Several new amides 4 of 5‐substituted 3‐methyl‐4‐isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino‐acid esters. Activities of the obtai...
Gespeichert in:
| Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 2005-07, Vol.338 (7), p.322-328 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 328 |
|---|---|
| container_issue | 7 |
| container_start_page | 322 |
| container_title | Archiv der Pharmazie (Weinheim) |
| container_volume | 338 |
| creator | Lipnicka, Urszula Regiec, Andrzej Sułkowski, Emil Zimecki, Michał |
| description | Several new amides 4 of 5‐substituted 3‐methyl‐4‐isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino‐acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo. |
| doi_str_mv | 10.1002/ardp.200400903 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68035859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20813363</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4123-733b611c8020418c24f5df12e1925d96d90063286b21c29cf7d4130cc2128f0f3</originalsourceid><addsrcrecordid>eNqFkEtvEzEURi0EoqGwZYlmxc7h-l7bmVkOBdpI6UM8xNJyPB7FMBOn9oR2-PWkTVS668qLe74j6zD2VsBUAOAHm5rNFAEkQAX0jE2EQsGlKOVzNgHSimskOmKvcv4FAASoXrIjoSqFKOWEmQt_U9R9aHwuYlsoXruxs31YR0783A-rseOSz3McVsH-jZ13Ni3j7dgFV9QuNIVdN8Ww8iEV877fruOQ4ub-NoQ_YRhfsxet7bJ_c3iP2Y8vn7-fnPHF5en8pF5wJwUSnxEttRCuBITd5x3KVjWtQC8qVE2lmwpAE5Z6icJh5dpZIwWBcyiwbKGlY_Z-792keL31eTB9yM53nV37uM1Gl0CqVNWTIEIpiDTtwOkedCnmnHxrNin0No1GgLlrb-7am4f2u8G7g3m77H3zHz_E3gHVHrgJnR-f0Jn666erx3K-34Y8-NuHrU2_jZ7RTJmfF6fm7OM3IRZwZRb0D-0Pnb8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20813363</pqid></control><display><type>article</type><title>New Amides of 5-Acylamino-3-Methyl-4-Isothiazolecarboxylic Acid and their Immunotropic Activity</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lipnicka, Urszula ; Regiec, Andrzej ; Sułkowski, Emil ; Zimecki, Michał</creator><creatorcontrib>Lipnicka, Urszula ; Regiec, Andrzej ; Sułkowski, Emil ; Zimecki, Michał</creatorcontrib><description>Several new amides 4 of 5‐substituted 3‐methyl‐4‐isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino‐acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo.</description><identifier>ISSN: 0365-6233</identifier><identifier>EISSN: 1521-4184</identifier><identifier>DOI: 10.1002/ardp.200400903</identifier><identifier>PMID: 15952244</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>5-amino-3-methylisothiazolecarboxamides ; Amides - chemical synthesis ; Amides - immunology ; Amides - pharmacology ; Animals ; Antibody Formation - drug effects ; Antibody Formation - immunology ; Cell Proliferation - drug effects ; Chemistry, Pharmaceutical - methods ; Chemistry, Pharmaceutical - trends ; Erythrocytes - drug effects ; Erythrocytes - immunology ; Hypersensitivity, Delayed - drug therapy ; Hypersensitivity, Delayed - immunology ; Immunotropic activity ; Male ; Mice ; Mice, Inbred CBA ; Sheep ; Spleen - cytology ; Synthesis ; Thiazoles - chemical synthesis ; Thiazoles - immunology ; Thiazoles - pharmacology</subject><ispartof>Archiv der Pharmazie (Weinheim), 2005-07, Vol.338 (7), p.322-328</ispartof><rights>Copyright © 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4123-733b611c8020418c24f5df12e1925d96d90063286b21c29cf7d4130cc2128f0f3</citedby><cites>FETCH-LOGICAL-c4123-733b611c8020418c24f5df12e1925d96d90063286b21c29cf7d4130cc2128f0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fardp.200400903$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15952244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lipnicka, Urszula</creatorcontrib><creatorcontrib>Regiec, Andrzej</creatorcontrib><creatorcontrib>Sułkowski, Emil</creatorcontrib><creatorcontrib>Zimecki, Michał</creatorcontrib><title>New Amides of 5-Acylamino-3-Methyl-4-Isothiazolecarboxylic Acid and their Immunotropic Activity</title><title>Archiv der Pharmazie (Weinheim)</title><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><description>Several new amides 4 of 5‐substituted 3‐methyl‐4‐isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino‐acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo.</description><subject>5-amino-3-methylisothiazolecarboxamides</subject><subject>Amides - chemical synthesis</subject><subject>Amides - immunology</subject><subject>Amides - pharmacology</subject><subject>Animals</subject><subject>Antibody Formation - drug effects</subject><subject>Antibody Formation - immunology</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chemistry, Pharmaceutical - trends</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - immunology</subject><subject>Hypersensitivity, Delayed - drug therapy</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immunotropic activity</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Sheep</subject><subject>Spleen - cytology</subject><subject>Synthesis</subject><subject>Thiazoles - chemical synthesis</subject><subject>Thiazoles - immunology</subject><subject>Thiazoles - pharmacology</subject><issn>0365-6233</issn><issn>1521-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtvEzEURi0EoqGwZYlmxc7h-l7bmVkOBdpI6UM8xNJyPB7FMBOn9oR2-PWkTVS668qLe74j6zD2VsBUAOAHm5rNFAEkQAX0jE2EQsGlKOVzNgHSimskOmKvcv4FAASoXrIjoSqFKOWEmQt_U9R9aHwuYlsoXruxs31YR0783A-rseOSz3McVsH-jZ13Ni3j7dgFV9QuNIVdN8Ww8iEV877fruOQ4ub-NoQ_YRhfsxet7bJ_c3iP2Y8vn7-fnPHF5en8pF5wJwUSnxEttRCuBITd5x3KVjWtQC8qVE2lmwpAE5Z6icJh5dpZIwWBcyiwbKGlY_Z-792keL31eTB9yM53nV37uM1Gl0CqVNWTIEIpiDTtwOkedCnmnHxrNin0No1GgLlrb-7am4f2u8G7g3m77H3zHz_E3gHVHrgJnR-f0Jn666erx3K-34Y8-NuHrU2_jZ7RTJmfF6fm7OM3IRZwZRb0D-0Pnb8</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Lipnicka, Urszula</creator><creator>Regiec, Andrzej</creator><creator>Sułkowski, Emil</creator><creator>Zimecki, Michał</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>New Amides of 5-Acylamino-3-Methyl-4-Isothiazolecarboxylic Acid and their Immunotropic Activity</title><author>Lipnicka, Urszula ; Regiec, Andrzej ; Sułkowski, Emil ; Zimecki, Michał</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4123-733b611c8020418c24f5df12e1925d96d90063286b21c29cf7d4130cc2128f0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>5-amino-3-methylisothiazolecarboxamides</topic><topic>Amides - chemical synthesis</topic><topic>Amides - immunology</topic><topic>Amides - pharmacology</topic><topic>Animals</topic><topic>Antibody Formation - drug effects</topic><topic>Antibody Formation - immunology</topic><topic>Cell Proliferation - drug effects</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Chemistry, Pharmaceutical - trends</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - immunology</topic><topic>Hypersensitivity, Delayed - drug therapy</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immunotropic activity</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Sheep</topic><topic>Spleen - cytology</topic><topic>Synthesis</topic><topic>Thiazoles - chemical synthesis</topic><topic>Thiazoles - immunology</topic><topic>Thiazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lipnicka, Urszula</creatorcontrib><creatorcontrib>Regiec, Andrzej</creatorcontrib><creatorcontrib>Sułkowski, Emil</creatorcontrib><creatorcontrib>Zimecki, Michał</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archiv der Pharmazie (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lipnicka, Urszula</au><au>Regiec, Andrzej</au><au>Sułkowski, Emil</au><au>Zimecki, Michał</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Amides of 5-Acylamino-3-Methyl-4-Isothiazolecarboxylic Acid and their Immunotropic Activity</atitle><jtitle>Archiv der Pharmazie (Weinheim)</jtitle><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><date>2005-07</date><risdate>2005</risdate><volume>338</volume><issue>7</issue><spage>322</spage><epage>328</epage><pages>322-328</pages><issn>0365-6233</issn><eissn>1521-4184</eissn><abstract>Several new amides 4 of 5‐substituted 3‐methyl‐4‐isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino‐acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells (SRBCs) in vivo.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>15952244</pmid><doi>10.1002/ardp.200400903</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0365-6233 |
| ispartof | Archiv der Pharmazie (Weinheim), 2005-07, Vol.338 (7), p.322-328 |
| issn | 0365-6233 1521-4184 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68035859 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 5-amino-3-methylisothiazolecarboxamides Amides - chemical synthesis Amides - immunology Amides - pharmacology Animals Antibody Formation - drug effects Antibody Formation - immunology Cell Proliferation - drug effects Chemistry, Pharmaceutical - methods Chemistry, Pharmaceutical - trends Erythrocytes - drug effects Erythrocytes - immunology Hypersensitivity, Delayed - drug therapy Hypersensitivity, Delayed - immunology Immunotropic activity Male Mice Mice, Inbred CBA Sheep Spleen - cytology Synthesis Thiazoles - chemical synthesis Thiazoles - immunology Thiazoles - pharmacology |
| title | New Amides of 5-Acylamino-3-Methyl-4-Isothiazolecarboxylic Acid and their Immunotropic Activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A19%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20Amides%20of%205-Acylamino-3-Methyl-4-Isothiazolecarboxylic%20Acid%20and%20their%20Immunotropic%20Activity&rft.jtitle=Archiv%20der%20Pharmazie%20(Weinheim)&rft.au=Lipnicka,%20Urszula&rft.date=2005-07&rft.volume=338&rft.issue=7&rft.spage=322&rft.epage=328&rft.pages=322-328&rft.issn=0365-6233&rft.eissn=1521-4184&rft_id=info:doi/10.1002/ardp.200400903&rft_dat=%3Cproquest_cross%3E20813363%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20813363&rft_id=info:pmid/15952244&rfr_iscdi=true |