Primary Mucosal Melanoma of Head and Neck: Prognostic Value of Clear Margins
Background: Primary mucosal melanomas of the head and neck (MMHN) are rare and carry a poor outcome. The impact of different treatments on survival is not yet clearly established. Methods: Twenty patients treated from 1991 to 2004 at a single referral center were retrospectively reviewed. Results: P...
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| Veröffentlicht in: | The Laryngoscope 2006-06, Vol.116 (6), p.993-995 |
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| creator | Penel, Nicolas Mallet, Yann Mirabel, Xavier Van, Jean Ton Lefebvre, Jean-Louis |
| description | Background: Primary mucosal melanomas of the head and neck (MMHN) are rare and carry a poor outcome. The impact of different treatments on survival is not yet clearly established.
Methods: Twenty patients treated from 1991 to 2004 at a single referral center were retrospectively reviewed.
Results: Primary sites were oral mucosa in 14 cases, paranasal sinuses in three cases, and nasal cavities in three cases. The sex ratio was equal to 1, and the median age at diagnosis was 63 years (range, 17–77 y). At presentation, one patient had lymph node metastases, one patient had distant metastases, and one patient had both. Surgery was performed with curative intent in 19 cases (and achieved clear margins in 14 cases). Postoperative radiation therapy was delivered in four cases. The actuarial 2‐year and 5‐year survival rates were 13/19 and 7/16. The risk factors for death were male gender (RR = 9.3 [1.2–72], P = .024) and positive margins (RR = 21 [1.9–47], P = .013). In addition, we observed three metachromous cancers (one breast cancer, one kidney cancer and one lymphoma) during the follow‐up period.
Conclusion: The present study suggests that obtaining clear margins must be the goal in the treatment of MMNH. |
| doi_str_mv | 10.1097/01.mlg.0000217236.06585.a9 |
| format | Article |
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Methods: Twenty patients treated from 1991 to 2004 at a single referral center were retrospectively reviewed.
Results: Primary sites were oral mucosa in 14 cases, paranasal sinuses in three cases, and nasal cavities in three cases. The sex ratio was equal to 1, and the median age at diagnosis was 63 years (range, 17–77 y). At presentation, one patient had lymph node metastases, one patient had distant metastases, and one patient had both. Surgery was performed with curative intent in 19 cases (and achieved clear margins in 14 cases). Postoperative radiation therapy was delivered in four cases. The actuarial 2‐year and 5‐year survival rates were 13/19 and 7/16. The risk factors for death were male gender (RR = 9.3 [1.2–72], P = .024) and positive margins (RR = 21 [1.9–47], P = .013). In addition, we observed three metachromous cancers (one breast cancer, one kidney cancer and one lymphoma) during the follow‐up period.
Conclusion: The present study suggests that obtaining clear margins must be the goal in the treatment of MMNH.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/01.mlg.0000217236.06585.a9</identifier><identifier>PMID: 16735914</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Dermatology ; Female ; Head and neck cancers ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - surgery ; Humans ; Lymphatic Metastasis ; Male ; Medical sciences ; Melanoma - mortality ; Melanoma - pathology ; Melanoma - surgery ; Middle Aged ; mucosal melanoma ; Neoplasm Metastasis ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Prognosis ; second cancers ; surgical margins ; Survival Rate ; Tumors ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>The Laryngoscope, 2006-06, Vol.116 (6), p.993-995</ispartof><rights>Copyright © 2006 The Triological Society</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5149-79755b08db46bb7a7cc9af7156e347713d7a154842b9fb1da56d392230a0ffcc3</citedby><cites>FETCH-LOGICAL-c5149-79755b08db46bb7a7cc9af7156e347713d7a154842b9fb1da56d392230a0ffcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2F01.mlg.0000217236.06585.a9$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2F01.mlg.0000217236.06585.a9$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17848148$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16735914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penel, Nicolas</creatorcontrib><creatorcontrib>Mallet, Yann</creatorcontrib><creatorcontrib>Mirabel, Xavier</creatorcontrib><creatorcontrib>Van, Jean Ton</creatorcontrib><creatorcontrib>Lefebvre, Jean-Louis</creatorcontrib><title>Primary Mucosal Melanoma of Head and Neck: Prognostic Value of Clear Margins</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Background: Primary mucosal melanomas of the head and neck (MMHN) are rare and carry a poor outcome. The impact of different treatments on survival is not yet clearly established.
Methods: Twenty patients treated from 1991 to 2004 at a single referral center were retrospectively reviewed.
Results: Primary sites were oral mucosa in 14 cases, paranasal sinuses in three cases, and nasal cavities in three cases. The sex ratio was equal to 1, and the median age at diagnosis was 63 years (range, 17–77 y). At presentation, one patient had lymph node metastases, one patient had distant metastases, and one patient had both. Surgery was performed with curative intent in 19 cases (and achieved clear margins in 14 cases). Postoperative radiation therapy was delivered in four cases. The actuarial 2‐year and 5‐year survival rates were 13/19 and 7/16. The risk factors for death were male gender (RR = 9.3 [1.2–72], P = .024) and positive margins (RR = 21 [1.9–47], P = .013). In addition, we observed three metachromous cancers (one breast cancer, one kidney cancer and one lymphoma) during the follow‐up period.
Conclusion: The present study suggests that obtaining clear margins must be the goal in the treatment of MMNH.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Female</subject><subject>Head and neck cancers</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - mortality</subject><subject>Melanoma - pathology</subject><subject>Melanoma - surgery</subject><subject>Middle Aged</subject><subject>mucosal melanoma</subject><subject>Neoplasm Metastasis</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>second cancers</subject><subject>surgical margins</subject><subject>Survival Rate</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtv1DAURi0EokPhL6AICXYJvvEr7q4adTpFmVLxLCvrxnFGoXkUeyLaf4-HjJg13tiSz_38-RDyBmgGVKv3FLK-22Y0rhxUzmRGpShEhvoJWYBgkHKtxVOyiPcsLUR-e0JehPCTUlBM0OfkBGQ8aOALUt74tkf_mGwmOwbsko3rcBh7TMYmWTusExzq5NrZu7Pkxo_bYQy71ibfsJvcHll2Dn2yQb9th_CSPGuwC-7VYT8lX1cXX5brtPx4ebU8L1MrgOtUaSVERYu64rKqFCprNTYKhHSMKwWsVgiCFzyvdFNBjULWTOc5o0ibxlp2St7Nufd-_DW5sDN9G6zrYnM3TsHIgjKhOI_g2QxaP4bgXWPu5-8aoGbv0lAw0aU5ujR_XRrUcfj14ZWp6l19HD3Ii8DbA4DBYtd4HGwbjpwqeAG8iNxq5n63nXv8jwqmPP_0QwgOIKnM943SOagNO_fwLwj9nYmdlDDfry_Nag2fPxS3YEr2B0nSn_g</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Penel, Nicolas</creator><creator>Mallet, Yann</creator><creator>Mirabel, Xavier</creator><creator>Van, Jean Ton</creator><creator>Lefebvre, Jean-Louis</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200606</creationdate><title>Primary Mucosal Melanoma of Head and Neck: Prognostic Value of Clear Margins</title><author>Penel, Nicolas ; Mallet, Yann ; Mirabel, Xavier ; Van, Jean Ton ; Lefebvre, Jean-Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5149-79755b08db46bb7a7cc9af7156e347713d7a154842b9fb1da56d392230a0ffcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Female</topic><topic>Head and neck cancers</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - mortality</topic><topic>Melanoma - pathology</topic><topic>Melanoma - surgery</topic><topic>Middle Aged</topic><topic>mucosal melanoma</topic><topic>Neoplasm Metastasis</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>second cancers</topic><topic>surgical margins</topic><topic>Survival Rate</topic><topic>Tumors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penel, Nicolas</creatorcontrib><creatorcontrib>Mallet, Yann</creatorcontrib><creatorcontrib>Mirabel, Xavier</creatorcontrib><creatorcontrib>Van, Jean Ton</creatorcontrib><creatorcontrib>Lefebvre, Jean-Louis</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penel, Nicolas</au><au>Mallet, Yann</au><au>Mirabel, Xavier</au><au>Van, Jean Ton</au><au>Lefebvre, Jean-Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary Mucosal Melanoma of Head and Neck: Prognostic Value of Clear Margins</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2006-06</date><risdate>2006</risdate><volume>116</volume><issue>6</issue><spage>993</spage><epage>995</epage><pages>993-995</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Background: Primary mucosal melanomas of the head and neck (MMHN) are rare and carry a poor outcome. The impact of different treatments on survival is not yet clearly established.
Methods: Twenty patients treated from 1991 to 2004 at a single referral center were retrospectively reviewed.
Results: Primary sites were oral mucosa in 14 cases, paranasal sinuses in three cases, and nasal cavities in three cases. The sex ratio was equal to 1, and the median age at diagnosis was 63 years (range, 17–77 y). At presentation, one patient had lymph node metastases, one patient had distant metastases, and one patient had both. Surgery was performed with curative intent in 19 cases (and achieved clear margins in 14 cases). Postoperative radiation therapy was delivered in four cases. The actuarial 2‐year and 5‐year survival rates were 13/19 and 7/16. The risk factors for death were male gender (RR = 9.3 [1.2–72], P = .024) and positive margins (RR = 21 [1.9–47], P = .013). In addition, we observed three metachromous cancers (one breast cancer, one kidney cancer and one lymphoma) during the follow‐up period.
Conclusion: The present study suggests that obtaining clear margins must be the goal in the treatment of MMNH.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>16735914</pmid><doi>10.1097/01.mlg.0000217236.06585.a9</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Dermatology Female Head and neck cancers Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - surgery Humans Lymphatic Metastasis Male Medical sciences Melanoma - mortality Melanoma - pathology Melanoma - surgery Middle Aged mucosal melanoma Neoplasm Metastasis Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Prognosis second cancers surgical margins Survival Rate Tumors Tumors of the skin and soft tissue. Premalignant lesions |
| title | Primary Mucosal Melanoma of Head and Neck: Prognostic Value of Clear Margins |
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