Age-Related Expression of α-Gustducin in the Rat Larynx
Objectives: The age-related changes in distribution of α-gustducin–immunoreactive structures in the larynx of Sprague-Dawley rats were studied. Methods: For this purpose, tissues obtained from 12 male rats ranging in age from 5 to 21 weeks were compared with respect to the distribution and morpholog...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2006-05, Vol.115 (5), p.387-393 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Nishio, Takeshi Koike, Shinobu Okano, Hiroyuki Bamba, Hitoshi Hisa, Yasuo |
| description | Objectives:
The age-related changes in distribution of α-gustducin–immunoreactive structures in the larynx of Sprague-Dawley rats were studied.
Methods:
For this purpose, tissues obtained from 12 male rats ranging in age from 5 to 21 weeks were compared with respect to the distribution and morphology of laryngeal taste buds immunoreactive for α-gustducin, the α-subunit of a taste cell–specific G protein.
Results:
Three different morphological types of α-gustducin–immunoreactive structures were seen: typical gemmal forms, clusters composed of 2 or 3 cells, and isolated immunoreactive cells not associated with taste buds. α-Gustducin–immunoreactive structures were most abundant in the epiglottis in all age groups. α-Gustducin–immunoreactive cells in rats seem to be located along the lateral food channels, in which they may come in contact with food. The total number of these α-gustducin–immunoreactive structures did not show any age-related changes, but the percentage of solitary immunoreactive cells in 5-week-old rats was significantly larger than the percentages in 8-, 14-, and 21-week-old animals.
Conclusions:
Solitary α-gustducin–immunoreactive cells, which are abundant in 5-week-old rats but are found in fewer numbers along the base of the epiglottis in mature rats, may be nociceptic in function, whereas the chemosensory clusters or buds that contain α-gustducin–positive cells and are distributed along the lateral food channels on the pharyngeal side of the larynx may have a role in gustatory reception. |
| doi_str_mv | 10.1177/000348940611500512 |
| format | Article |
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The age-related changes in distribution of α-gustducin–immunoreactive structures in the larynx of Sprague-Dawley rats were studied.
Methods:
For this purpose, tissues obtained from 12 male rats ranging in age from 5 to 21 weeks were compared with respect to the distribution and morphology of laryngeal taste buds immunoreactive for α-gustducin, the α-subunit of a taste cell–specific G protein.
Results:
Three different morphological types of α-gustducin–immunoreactive structures were seen: typical gemmal forms, clusters composed of 2 or 3 cells, and isolated immunoreactive cells not associated with taste buds. α-Gustducin–immunoreactive structures were most abundant in the epiglottis in all age groups. α-Gustducin–immunoreactive cells in rats seem to be located along the lateral food channels, in which they may come in contact with food. The total number of these α-gustducin–immunoreactive structures did not show any age-related changes, but the percentage of solitary immunoreactive cells in 5-week-old rats was significantly larger than the percentages in 8-, 14-, and 21-week-old animals.
Conclusions:
Solitary α-gustducin–immunoreactive cells, which are abundant in 5-week-old rats but are found in fewer numbers along the base of the epiglottis in mature rats, may be nociceptic in function, whereas the chemosensory clusters or buds that contain α-gustducin–positive cells and are distributed along the lateral food channels on the pharyngeal side of the larynx may have a role in gustatory reception.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940611500512</identifier><identifier>PMID: 16739672</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aging - metabolism ; Animals ; Biological and medical sciences ; Biomarkers - metabolism ; Larynx - cytology ; Larynx - growth & development ; Larynx - metabolism ; Male ; Medical sciences ; Otorhinolaryngology. Stomatology ; Rats ; Rats, Sprague-Dawley ; Transducin - biosynthesis</subject><ispartof>Annals of otology, rhinology & laryngology, 2006-05, Vol.115 (5), p.387-393</ispartof><rights>2006 SAGE Publications</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-25cf71ee3582f24ec7e2ab714735b272b4d9731e8d5efd88098008f033871043</citedby><cites>FETCH-LOGICAL-c371t-25cf71ee3582f24ec7e2ab714735b272b4d9731e8d5efd88098008f033871043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000348940611500512$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000348940611500512$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>309,310,314,778,782,787,788,21802,23913,23914,25123,27907,27908,43604,43605</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17781871$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16739672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishio, Takeshi</creatorcontrib><creatorcontrib>Koike, Shinobu</creatorcontrib><creatorcontrib>Okano, Hiroyuki</creatorcontrib><creatorcontrib>Bamba, Hitoshi</creatorcontrib><creatorcontrib>Hisa, Yasuo</creatorcontrib><title>Age-Related Expression of α-Gustducin in the Rat Larynx</title><title>Annals of otology, rhinology & laryngology</title><addtitle>Ann Otol Rhinol Laryngol</addtitle><description>Objectives:
The age-related changes in distribution of α-gustducin–immunoreactive structures in the larynx of Sprague-Dawley rats were studied.
Methods:
For this purpose, tissues obtained from 12 male rats ranging in age from 5 to 21 weeks were compared with respect to the distribution and morphology of laryngeal taste buds immunoreactive for α-gustducin, the α-subunit of a taste cell–specific G protein.
Results:
Three different morphological types of α-gustducin–immunoreactive structures were seen: typical gemmal forms, clusters composed of 2 or 3 cells, and isolated immunoreactive cells not associated with taste buds. α-Gustducin–immunoreactive structures were most abundant in the epiglottis in all age groups. α-Gustducin–immunoreactive cells in rats seem to be located along the lateral food channels, in which they may come in contact with food. The total number of these α-gustducin–immunoreactive structures did not show any age-related changes, but the percentage of solitary immunoreactive cells in 5-week-old rats was significantly larger than the percentages in 8-, 14-, and 21-week-old animals.
Conclusions:
Solitary α-gustducin–immunoreactive cells, which are abundant in 5-week-old rats but are found in fewer numbers along the base of the epiglottis in mature rats, may be nociceptic in function, whereas the chemosensory clusters or buds that contain α-gustducin–positive cells and are distributed along the lateral food channels on the pharyngeal side of the larynx may have a role in gustatory reception.</description><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Larynx - cytology</subject><subject>Larynx - growth & development</subject><subject>Larynx - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Transducin - biosynthesis</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtKw0AUBuBBFFurL-BCstFd7Fx7JssitQoFoXThLkwmZ2pKmtRMAvWxfBGfySkNdCEIA4eB71z4Cbll9JExgDGlVEidSDphTFGqGD8jQ5ZIESvg7-dkeADxQQzIlfeb8JWK8ksyYBMQyQT4kOjpGuMllqbFPJrtdw16X9RVVLvo5zued77NO1tUUXjtB0ZL00YL03xV-2ty4Uzp8aavI7J6nq2eXuLF2_z1abqIrQDWxlxZBwxRKM0dl2gBucmASRAq48AzmScgGOpcocu1pommVDsqhAZGpRiRh-PYXVN_dujbdFt4i2VpKqw7n050oKBogPwIbVN736BLd02xDaemjKaHuNK_cYWmu356l20xP7X0-QRw3wPjrSldYypb-JMD0CwcGtz46LxZY7qpu6YKofy3-hf2LX1D</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Nishio, Takeshi</creator><creator>Koike, Shinobu</creator><creator>Okano, Hiroyuki</creator><creator>Bamba, Hitoshi</creator><creator>Hisa, Yasuo</creator><general>SAGE Publications</general><general>Annals Publishing Compagny</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20060501</creationdate><title>Age-Related Expression of α-Gustducin in the Rat Larynx</title><author>Nishio, Takeshi ; Koike, Shinobu ; Okano, Hiroyuki ; Bamba, Hitoshi ; Hisa, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-25cf71ee3582f24ec7e2ab714735b272b4d9731e8d5efd88098008f033871043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Larynx - cytology</topic><topic>Larynx - growth & development</topic><topic>Larynx - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Transducin - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishio, Takeshi</creatorcontrib><creatorcontrib>Koike, Shinobu</creatorcontrib><creatorcontrib>Okano, Hiroyuki</creatorcontrib><creatorcontrib>Bamba, Hitoshi</creatorcontrib><creatorcontrib>Hisa, Yasuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishio, Takeshi</au><au>Koike, Shinobu</au><au>Okano, Hiroyuki</au><au>Bamba, Hitoshi</au><au>Hisa, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-Related Expression of α-Gustducin in the Rat Larynx</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>115</volume><issue>5</issue><spage>387</spage><epage>393</epage><pages>387-393</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>Objectives:
The age-related changes in distribution of α-gustducin–immunoreactive structures in the larynx of Sprague-Dawley rats were studied.
Methods:
For this purpose, tissues obtained from 12 male rats ranging in age from 5 to 21 weeks were compared with respect to the distribution and morphology of laryngeal taste buds immunoreactive for α-gustducin, the α-subunit of a taste cell–specific G protein.
Results:
Three different morphological types of α-gustducin–immunoreactive structures were seen: typical gemmal forms, clusters composed of 2 or 3 cells, and isolated immunoreactive cells not associated with taste buds. α-Gustducin–immunoreactive structures were most abundant in the epiglottis in all age groups. α-Gustducin–immunoreactive cells in rats seem to be located along the lateral food channels, in which they may come in contact with food. The total number of these α-gustducin–immunoreactive structures did not show any age-related changes, but the percentage of solitary immunoreactive cells in 5-week-old rats was significantly larger than the percentages in 8-, 14-, and 21-week-old animals.
Conclusions:
Solitary α-gustducin–immunoreactive cells, which are abundant in 5-week-old rats but are found in fewer numbers along the base of the epiglottis in mature rats, may be nociceptic in function, whereas the chemosensory clusters or buds that contain α-gustducin–positive cells and are distributed along the lateral food channels on the pharyngeal side of the larynx may have a role in gustatory reception.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>16739672</pmid><doi>10.1177/000348940611500512</doi><tpages>7</tpages></addata></record> |
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| ispartof | Annals of otology, rhinology & laryngology, 2006-05, Vol.115 (5), p.387-393 |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Aging - metabolism Animals Biological and medical sciences Biomarkers - metabolism Larynx - cytology Larynx - growth & development Larynx - metabolism Male Medical sciences Otorhinolaryngology. Stomatology Rats Rats, Sprague-Dawley Transducin - biosynthesis |
| title | Age-Related Expression of α-Gustducin in the Rat Larynx |
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