Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A

RNA helicase A (RHA), a member of the DEXH box helicase family of proteins, is an integral component of protein complexes that regulate transcription and splicing. The EWS-FLI1 oncoprotein is expressed as a result of the chromosomal translocation t(11;22) that occurs in patients with the Ewing'...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-06, Vol.66 (11), p.5574-5581
Hauptverfasser:	TORETSKY, Jeffrey A, ERKIZAN, Verda, LEVENSON, Amy, ABAAN, Ogan D, PARVIN, Jeffrey D, CRIPE, Timothy P, RICE, Anna M, SEAN BONG LEE, ÜREN, Aykut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Autoantigens - biosynthesis Autoantigens - genetics Autoantigens - metabolism Biological and medical sciences Cell Adhesion - physiology Cell Growth Processes - physiology Cell Line, Tumor DEAD-box RNA Helicases Humans Medical sciences Mice Mice, Nude Neoplasm Proteins Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Peptide Library Peptides - metabolism Pharmacology. Drug treatments Promoter Regions, Genetic Protein Binding Proto-Oncogene Protein c-fli-1 - genetics Proto-Oncogene Protein c-fli-1 - metabolism Recombinant Proteins - metabolism RNA Helicases - biosynthesis RNA Helicases - genetics RNA Helicases - metabolism RNA-Binding Protein EWS Sarcoma, Ewing - enzymology Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Transcriptional Activation Transplantation, Heterologous Tumors
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