Evaluation of Solution Oxygenation Requirements for Azonitrile-Based Oxidative Forced Degradation Studies of Pharmaceutical Compounds

AIBN and ACVA oxidative forced degradation models are examined for two drug molecules whose predominant oxidation chemistries arise from different reaction mechanisms (i.e., free radical vs. nucleophilic). Stress was conducted under a variety of initiator concentrations, and under ambient and pressu...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2006-07, Vol.95 (7), p.1527-1539
Hauptverfasser:	Nelson, Eric D., Harmon, Paul A., Szymanik, Renee C., Teresk, Martin G., Li, Li, Seburg, Randal A., Reed, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles - chemistry ACVA AIBN Azo Compounds - chemistry Biological and medical sciences forced degradation General pharmacology Medical sciences Nitriles - chemistry oxidation Oxidation-Reduction oxygen Oxygen - analysis Oxygen - chemistry Peroxides - chemistry pharmaceutical Pharmaceutical Preparations Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Valerates - chemistry
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