Effects of pH, Temperature, and Sucrose on Benzyl Alcohol-Induced Aggregation of Recombinant Human Granulocyte Colony Stimulating Factor

Antimicrobial preservatives (e.g., benzyl alcohol), which are required in multidose formulations, can induce protein aggregation. In this study, the mechanism of benzyl alcohol-induced aggregation of recombinant human granulocyte colony-stimulating factor (rhGCSF) was investigated by determining the...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2006-07, Vol.95 (7), p.1480-1497
Hauptverfasser:	Thirumangalathu, Renuka, Krishnan, Sampathkumar, Brems, David N., Randolph, Theodore W., Carpenter, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation benzyl alcohol Benzyl Alcohol - chemistry Biological and medical sciences Chromatography, Gel Circular Dichroism Deuterium Exchange Measurement General pharmacology Granulocyte Colony-Stimulating Factor - chemistry Humans Hydrogen-Ion Concentration Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins rhGCSF Spectrophotometry, Infrared Sucrose - chemistry Temperature
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