Acarbose, an α-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation

Several epidemiological studies have revealed that subjects with postprandial hyperglycemia are at increased risk of cardiovascular disease. However, the impact of postprandial hyperglycemia and its treatment on endothelial function has not been clarified yet. In this study, Goto-Kakizaki (GK) rats,...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-06, Vol.345 (2), p.688-693
Hauptverfasser:	Azuma, Kosuke, Toyofuku, Yukiko, Iesaki, Takafumi, Otsuka, Aiko, Tanaka, Atsuko, Mita, Tomoya, Hirose, Takahisa, Tanaka, Yasushi, Daida, Hiroyuki, Kawamori, Ryuzo, Watada, Hirotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Acarbose - therapeutic use Acetylcholine - pharmacology Animals Aorta - pathology Blood Glucose - metabolism Cardiovascular disease Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Endothelial dysfunction Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Enzyme Inhibitors - therapeutic use Hyperglycemia - drug therapy Hypoglycemic Agents - therapeutic use Models, Animal Postprandial hyperglycemia Postprandial Period - drug effects Rats Time Factors Tunica Intima - pathology Type 2 diabetes mellitus
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