Hypoxia regulates PDGF-B interactions between glomerular capillary endothelial and mesangial cells

Hypoxia regulates PDGF-B interactions between glomerular capillary endothelial and mesangial cells. Platelet-derived growth factor (PDGF)-B regulates mesangial cell and vessel development during embryogenesis, and contributes to the pathogenesis of adult renal and vascular diseases. Endothelial cell...

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Veröffentlicht in:	Kidney international 2005-08, Vol.68 (2), p.695-703
Hauptverfasser:	Eng, Eudora, Holgren, Cory, Hubchak, Susan, Naaz, Parveen, Schnaper, H. William
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cattle Cell Communication - physiology Cell Membrane - metabolism Cell Movement - physiology Cells, Cultured Endothelial Cells - cytology Endothelial Cells - metabolism glomerular endothelial cell Glomerular Mesangium - cytology Glomerular Mesangium - metabolism hypoxia Hypoxia - metabolism Hypoxia - pathology Hypoxia - physiopathology Hypoxia-Inducible Factor 1, alpha Subunit Kidney Glomerulus - blood supply Kidney Glomerulus - cytology Kidney Glomerulus - metabolism Medical sciences mesangial cell Nephrology. Urinary tract diseases PDGF-B PDGF-β receptor Protein Binding - physiology Proto-Oncogene Proteins c-sis - genetics Proto-Oncogene Proteins c-sis - metabolism Receptor, Platelet-Derived Growth Factor beta - metabolism renal organogenesis specific binding capacity Transcription Factors - metabolism Transcription, Genetic - physiology Vascular Endothelial Growth Factor A - metabolism vessel formation
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