Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties

Synthesis and biological activity of novel methionine aminopeptidase type -2 inhibitors having a sulfonamide bond are reported. We have screened molecules for inhibition of MetAP2 as a novel approach toward antiangiogenesis and anticancer therapy using affinity selection/mass spectrometry (ASMS) emp...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-07, Vol.16 (13), p.3574-3577
Hauptverfasser:	Kawai, Megumi, BaMaung, Nwe Y., Fidanze, Steve D., Erickson, Scott A., Tedrow, Jason S., Sanders, William J., Vasudevan, Anil, Park, Chang, Hutchins, Charles, Comess, Kenneth M., Kalvin, Douglas, Wang, Jieyi, Zhang, Qian, Lou, Pingping, Tucker-Garcia, Lora, Bouska, Jennifer, Bell, Randy L., Lesniewski, Richard, Henkin, Jack, Sheppard, George S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopeptidases - antagonists & inhibitors Angiogenesis Inhibitors - chemical synthesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferative Binding Sites Biological and medical sciences Cell Line Cell Proliferation - drug effects Crystallography, X-Ray Drug Screening Assays, Antitumor General aspects Glycoproteins - antagonists & inhibitors Humans Manganese - chemistry Mass Spectrometry - methods Medical sciences MetAP2 Models, Molecular Molecular Structure Pharmacology. Drug treatments Sensitivity and Specificity Stereoisomerism Structure-Activity Relationship Sulfonamide Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
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