The ICln interactome
The many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain...
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| Veröffentlicht in: | Acta Physiologica 2006-05, Vol.187 (1-2), p.43-49 |
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| container_issue | 1-2 |
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| container_title | Acta Physiologica |
| container_volume | 187 |
| creator | Fürst, J. Bottà, G. Saino, S. Dopinto, S. Gandini, R. Dossena, S. Vezzoli, V. Rodighiero, S. Bazzini, C. Garavaglia, M. L. Meyer, G. Jakab, M. Ritter, M. Wappl-Kornherr, E. Paulmichl, M. |
| description | The many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one‐protein–one‐function base. Therefore, the study of the interactome of the different proteins is of utmost importance. Here, we describe the present knowledge of the ICln interactome. ICln is a protein, we cloned and whose function was reported to be as divers as (i) ion permeation, (ii) cytoskeletal organization, and (iii) RNA processing. The role of ICln in these different functional modules can be described best as being a ‘connector hub’ with ‘date hub’ function. |
| doi_str_mv | 10.1111/j.1748-1716.2006.01549.x |
| format | Article |
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ICln is a protein, we cloned and whose function was reported to be as divers as (i) ion permeation, (ii) cytoskeletal organization, and (iii) RNA processing. The role of ICln in these different functional modules can be described best as being a ‘connector hub’ with ‘date hub’ function.</description><identifier>ISSN: 1748-1708</identifier><identifier>EISSN: 1748-1716</identifier><identifier>DOI: 10.1111/j.1748-1716.2006.01549.x</identifier><identifier>PMID: 16734741</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Binding Sites ; Cell Membrane - metabolism ; Cells - metabolism ; Humans ; ICln ; interactomics ; Ion Channel Gating ; ion channels ; Ion Channels - metabolism ; methylosome ; Proteomics ; RNA-processing ; Signal Transduction - physiology ; Structure-Activity Relationship ; volume regulation</subject><ispartof>Acta Physiologica, 2006-05, Vol.187 (1-2), p.43-49</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4069-eb0091945dc77c2b4a919859006e10bf29eb331637122a6a33003b60808caef93</citedby><cites>FETCH-LOGICAL-c4069-eb0091945dc77c2b4a919859006e10bf29eb331637122a6a33003b60808caef93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1748-1716.2006.01549.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1748-1716.2006.01549.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16734741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fürst, J.</creatorcontrib><creatorcontrib>Bottà, G.</creatorcontrib><creatorcontrib>Saino, S.</creatorcontrib><creatorcontrib>Dopinto, S.</creatorcontrib><creatorcontrib>Gandini, R.</creatorcontrib><creatorcontrib>Dossena, S.</creatorcontrib><creatorcontrib>Vezzoli, V.</creatorcontrib><creatorcontrib>Rodighiero, S.</creatorcontrib><creatorcontrib>Bazzini, C.</creatorcontrib><creatorcontrib>Garavaglia, M. L.</creatorcontrib><creatorcontrib>Meyer, G.</creatorcontrib><creatorcontrib>Jakab, M.</creatorcontrib><creatorcontrib>Ritter, M.</creatorcontrib><creatorcontrib>Wappl-Kornherr, E.</creatorcontrib><creatorcontrib>Paulmichl, M.</creatorcontrib><title>The ICln interactome</title><title>Acta Physiologica</title><addtitle>Acta Physiol (Oxf)</addtitle><description>The many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one‐protein–one‐function base. Therefore, the study of the interactome of the different proteins is of utmost importance. Here, we describe the present knowledge of the ICln interactome. ICln is a protein, we cloned and whose function was reported to be as divers as (i) ion permeation, (ii) cytoskeletal organization, and (iii) RNA processing. The role of ICln in these different functional modules can be described best as being a ‘connector hub’ with ‘date hub’ function.</description><subject>Binding Sites</subject><subject>Cell Membrane - metabolism</subject><subject>Cells - metabolism</subject><subject>Humans</subject><subject>ICln</subject><subject>interactomics</subject><subject>Ion Channel Gating</subject><subject>ion channels</subject><subject>Ion Channels - metabolism</subject><subject>methylosome</subject><subject>Proteomics</subject><subject>RNA-processing</subject><subject>Signal Transduction - physiology</subject><subject>Structure-Activity Relationship</subject><subject>volume regulation</subject><issn>1748-1708</issn><issn>1748-1716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PwkAQhjdGIwS5eTacvLXOfnS3ezEhRIEEP6IYvE22ZRuLLcVuifDvbS3Bq3OZmew7z-y8hAwo-LSOm5VPlQg9qqj0GYD0gQZC-7sT0j0-nB5rCDuk79wKACijXDB2TjpUKi6UoF1yOf-wg-koWw_SdWVLE1dFbi_IWWIyZ_uH3CNv93fz0cSbPY2no-HMiwVI7dkIQFMtgmWsVMwiYeouDHT9J0shSpi2EedUckUZM9JwDsAjCSGEsbGJ5j1y3XI3ZfG1ta7CPHWxzTKztsXWoQyBaQmNMGyFcVk4V9oEN2Wam3KPFLAxBVfY3IvN7diYgr-m4K4evTrs2Ea5Xf4NHiyoBbet4DvN7P7fYBw-T4ZNWQO8FpC6yu6OAFN-Yr1DBbh4HONc8NeHd7bAF_4DveB7ew</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Fürst, J.</creator><creator>Bottà, G.</creator><creator>Saino, S.</creator><creator>Dopinto, S.</creator><creator>Gandini, R.</creator><creator>Dossena, S.</creator><creator>Vezzoli, V.</creator><creator>Rodighiero, S.</creator><creator>Bazzini, C.</creator><creator>Garavaglia, M. L.</creator><creator>Meyer, G.</creator><creator>Jakab, M.</creator><creator>Ritter, M.</creator><creator>Wappl-Kornherr, E.</creator><creator>Paulmichl, M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>The ICln interactome</title><author>Fürst, J. ; Bottà, G. ; Saino, S. ; Dopinto, S. ; Gandini, R. ; Dossena, S. ; Vezzoli, V. ; Rodighiero, S. ; Bazzini, C. ; Garavaglia, M. L. ; Meyer, G. ; Jakab, M. ; Ritter, M. ; Wappl-Kornherr, E. ; Paulmichl, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4069-eb0091945dc77c2b4a919859006e10bf29eb331637122a6a33003b60808caef93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Binding Sites</topic><topic>Cell Membrane - metabolism</topic><topic>Cells - metabolism</topic><topic>Humans</topic><topic>ICln</topic><topic>interactomics</topic><topic>Ion Channel Gating</topic><topic>ion channels</topic><topic>Ion Channels - metabolism</topic><topic>methylosome</topic><topic>Proteomics</topic><topic>RNA-processing</topic><topic>Signal Transduction - physiology</topic><topic>Structure-Activity Relationship</topic><topic>volume regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fürst, J.</creatorcontrib><creatorcontrib>Bottà, G.</creatorcontrib><creatorcontrib>Saino, S.</creatorcontrib><creatorcontrib>Dopinto, S.</creatorcontrib><creatorcontrib>Gandini, R.</creatorcontrib><creatorcontrib>Dossena, S.</creatorcontrib><creatorcontrib>Vezzoli, V.</creatorcontrib><creatorcontrib>Rodighiero, S.</creatorcontrib><creatorcontrib>Bazzini, C.</creatorcontrib><creatorcontrib>Garavaglia, M. 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Here, we describe the present knowledge of the ICln interactome. ICln is a protein, we cloned and whose function was reported to be as divers as (i) ion permeation, (ii) cytoskeletal organization, and (iii) RNA processing. The role of ICln in these different functional modules can be described best as being a ‘connector hub’ with ‘date hub’ function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16734741</pmid><doi>10.1111/j.1748-1716.2006.01549.x</doi><tpages>7</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Binding Sites Cell Membrane - metabolism Cells - metabolism Humans ICln interactomics Ion Channel Gating ion channels Ion Channels - metabolism methylosome Proteomics RNA-processing Signal Transduction - physiology Structure-Activity Relationship volume regulation |
| title | The ICln interactome |
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