Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: Implications on diabetic neuropathy
Aspartoacylase (ASPA) hydrolyzes N-acetylaspartic acid (NAA) into aspartate and acetate. Normal hydrolysis of NAA is important to maintain healthy neurons. Since enteric neuropathy is one of the events seen in diabetes, whether ASPA activity is affected in diabetic condition is not known. In order t...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2006-07, Vol.345 (3), p.973-975 |
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| creator | Surendran, Sankar Matalon, Reuben Tyring, Stephen K. |
| description | Aspartoacylase (ASPA) hydrolyzes
N-acetylaspartic acid (NAA) into aspartate and acetate. Normal hydrolysis of NAA is important to maintain healthy neurons. Since enteric neuropathy is one of the events seen in diabetes, whether ASPA activity is affected in diabetic condition is not known. In order to investigate the possibility, ASPA activity was examined in the duodenum and brain of obesity induced diabetes model mouse. Aspartoacylase activity was high in the diabetic mouse duodenum compared to control duodenum. The same result was also observed by immunostaining of the mouse duodenum. The activity of ASPA was found to be elevated in the brain of diabetic mouse compared to the control brain. These data suggest that normal hydrolysis of NAA is affected by ASPA activity seen in the type 2 diabetes model mouse and this change is likely to contribute to neuropathy seen in diabetes, if documented also in patients with type 2 diabetes. |
| doi_str_mv | 10.1016/j.bbrc.2006.04.179 |
| format | Article |
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N-acetylaspartic acid (NAA) into aspartate and acetate. Normal hydrolysis of NAA is important to maintain healthy neurons. Since enteric neuropathy is one of the events seen in diabetes, whether ASPA activity is affected in diabetic condition is not known. In order to investigate the possibility, ASPA activity was examined in the duodenum and brain of obesity induced diabetes model mouse. Aspartoacylase activity was high in the diabetic mouse duodenum compared to control duodenum. The same result was also observed by immunostaining of the mouse duodenum. The activity of ASPA was found to be elevated in the brain of diabetic mouse compared to the control brain. These data suggest that normal hydrolysis of NAA is affected by ASPA activity seen in the type 2 diabetes model mouse and this change is likely to contribute to neuropathy seen in diabetes, if documented also in patients with type 2 diabetes.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2006.04.179</identifier><identifier>PMID: 16707098</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amidohydrolases - biosynthesis ; Animals ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Aspartoacylase ; Brain - metabolism ; Diabetes Mellitus, Experimental - enzymology ; Diabetic Neuropathies - enzymology ; Disease Models, Animal ; Duodenum ; Duodenum - enzymology ; Hydrolysis ; Mice ; Mice, Transgenic ; Neuropathy ; Obesity - enzymology ; Obesity induced diabetes ; Type 2 diabetes ; Up-Regulation</subject><ispartof>Biochemical and biophysical research communications, 2006-07, Vol.345 (3), p.973-975</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-716fe95cd87313809893a5b3c0005bfb4a82ab18e7f2e2a4a8f89dd974b452af3</citedby><cites>FETCH-LOGICAL-c385t-716fe95cd87313809893a5b3c0005bfb4a82ab18e7f2e2a4a8f89dd974b452af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X06009880$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16707098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Surendran, Sankar</creatorcontrib><creatorcontrib>Matalon, Reuben</creatorcontrib><creatorcontrib>Tyring, Stephen K.</creatorcontrib><title>Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: Implications on diabetic neuropathy</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Aspartoacylase (ASPA) hydrolyzes
N-acetylaspartic acid (NAA) into aspartate and acetate. Normal hydrolysis of NAA is important to maintain healthy neurons. Since enteric neuropathy is one of the events seen in diabetes, whether ASPA activity is affected in diabetic condition is not known. In order to investigate the possibility, ASPA activity was examined in the duodenum and brain of obesity induced diabetes model mouse. Aspartoacylase activity was high in the diabetic mouse duodenum compared to control duodenum. The same result was also observed by immunostaining of the mouse duodenum. The activity of ASPA was found to be elevated in the brain of diabetic mouse compared to the control brain. These data suggest that normal hydrolysis of NAA is affected by ASPA activity seen in the type 2 diabetes model mouse and this change is likely to contribute to neuropathy seen in diabetes, if documented also in patients with type 2 diabetes.</description><subject>Amidohydrolases - biosynthesis</subject><subject>Animals</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Aspartoacylase</subject><subject>Brain - metabolism</subject><subject>Diabetes Mellitus, Experimental - enzymology</subject><subject>Diabetic Neuropathies - enzymology</subject><subject>Disease Models, Animal</subject><subject>Duodenum</subject><subject>Duodenum - enzymology</subject><subject>Hydrolysis</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Neuropathy</subject><subject>Obesity - enzymology</subject><subject>Obesity induced diabetes</subject><subject>Type 2 diabetes</subject><subject>Up-Regulation</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rFTEUxYNY7GvrP-BCsnI3403mM-JGitpCwU0L3YV83LF5zEzGJFN4G__25jkP3OkqhPs7h3vPIeQdg5IBaz_uS62DKTlAW0Jdsk68IjsGAgrOoH5NdpAnBRfs8ZxcxLgHYKxuxRtyztoOOhD9jvx-WAL-XEeVnJ-pH6iKiwrJK3MYVUSqTHLPLh2om2l6QmpXb3FepyPqNcZtZFeDllqnNCaMdPJrxE_0dlpGZ_44R5rdt7kzdMY1-EWlp8MVORvUGPHt6b0kD9--3l_fFHc_vt9ef7krTNU3qehYO6BojO27ilV93lxUqtGVyRc2etC16rnSrMdu4MhV_g69sFZ0ta4brobqknzYfJfgf60Yk5xcNDiOasa8rGx74CLn81-QdZxD0zQZ5Btogo8x4CCX4CYVDpKBPNYj9_JYjzzWI6HOSpFF70_uq57Q_pWc-sjA5w3AHMazwyCjcTjndF1Ak6T17l_-LxR5o-E</recordid><startdate>20060707</startdate><enddate>20060707</enddate><creator>Surendran, Sankar</creator><creator>Matalon, Reuben</creator><creator>Tyring, Stephen K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060707</creationdate><title>Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: Implications on diabetic neuropathy</title><author>Surendran, Sankar ; Matalon, Reuben ; Tyring, Stephen K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-716fe95cd87313809893a5b3c0005bfb4a82ab18e7f2e2a4a8f89dd974b452af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Amidohydrolases - biosynthesis</topic><topic>Animals</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Aspartoacylase</topic><topic>Brain - metabolism</topic><topic>Diabetes Mellitus, Experimental - enzymology</topic><topic>Diabetic Neuropathies - enzymology</topic><topic>Disease Models, Animal</topic><topic>Duodenum</topic><topic>Duodenum - enzymology</topic><topic>Hydrolysis</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Neuropathy</topic><topic>Obesity - enzymology</topic><topic>Obesity induced diabetes</topic><topic>Type 2 diabetes</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Surendran, Sankar</creatorcontrib><creatorcontrib>Matalon, Reuben</creatorcontrib><creatorcontrib>Tyring, Stephen K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Surendran, Sankar</au><au>Matalon, Reuben</au><au>Tyring, Stephen K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: Implications on diabetic neuropathy</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2006-07-07</date><risdate>2006</risdate><volume>345</volume><issue>3</issue><spage>973</spage><epage>975</epage><pages>973-975</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Aspartoacylase (ASPA) hydrolyzes
N-acetylaspartic acid (NAA) into aspartate and acetate. Normal hydrolysis of NAA is important to maintain healthy neurons. Since enteric neuropathy is one of the events seen in diabetes, whether ASPA activity is affected in diabetic condition is not known. In order to investigate the possibility, ASPA activity was examined in the duodenum and brain of obesity induced diabetes model mouse. Aspartoacylase activity was high in the diabetic mouse duodenum compared to control duodenum. The same result was also observed by immunostaining of the mouse duodenum. The activity of ASPA was found to be elevated in the brain of diabetic mouse compared to the control brain. These data suggest that normal hydrolysis of NAA is affected by ASPA activity seen in the type 2 diabetes model mouse and this change is likely to contribute to neuropathy seen in diabetes, if documented also in patients with type 2 diabetes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16707098</pmid><doi>10.1016/j.bbrc.2006.04.179</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amidohydrolases - biosynthesis Animals Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Aspartoacylase Brain - metabolism Diabetes Mellitus, Experimental - enzymology Diabetic Neuropathies - enzymology Disease Models, Animal Duodenum Duodenum - enzymology Hydrolysis Mice Mice, Transgenic Neuropathy Obesity - enzymology Obesity induced diabetes Type 2 diabetes Up-Regulation |
| title | Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: Implications on diabetic neuropathy |
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