Rapid antidepressant response after nocturnal TRH administration in patients with bipolar type I and bipolar type II major depression

Thyrotropin-releasing hormone (TRH) is a tripeptide that produces endocrine and behavioral effects in animals and humans. Some studies have shown transient antidepressant activity after morning administration of TRH. We hypothesized that nocturnal administration of TRH, when the circadian sensitivit...

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Veröffentlicht in:	Journal of clinical psychopharmacology 2005-08, Vol.25 (4), p.325-330
Hauptverfasser:	SZUBA, Martin P, AMSTERDAM, Jay D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Bipolar Disorder - blood Bipolar Disorder - drug therapy Chronotherapy Double-Blind Method Female Humans Infusions, Intravenous Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Psychological Tests Thyroid Hormones - blood Thyrotropin - blood Thyrotropin-Releasing Hormone - administration & dosage Time Factors Treatment Outcome
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