Directed meta-Metalation Using Alkali-Metal-Mediated Zincation
Move over directed ortho‐metalation, here comes directed meta‐metalation. The unprecedented meta‐zincation of two anilides by a synergic mixed sodium/zinc dialkyl–amide base is presented. The orientation of the deprotonation of the anilides is remarkably switched to the meta site using this heterome...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2006-06, Vol.45 (23), p.3775-3778 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Armstrong, David R. Clegg, William Dale, Sophie H. Hevia, Eva Hogg, Lorna M. Honeyman, Gordon W. Mulvey, Robert E. |
| description | Move over directed ortho‐metalation, here comes directed meta‐metalation. The unprecedented meta‐zincation of two anilides by a synergic mixed sodium/zinc dialkyl–amide base is presented. The orientation of the deprotonation of the anilides is remarkably switched to the meta site using this heterometallic mixed‐metal system. |
| doi_str_mv | 10.1002/anie.200600720 |
| format | Article |
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| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | anilides deprotonation metalation sodium zincation |
| title | Directed meta-Metalation Using Alkali-Metal-Mediated Zincation |
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