Mini-peritoneal equilibration test: A simple and fast method to assess free water and small solute transport across the peritoneal membrane
Mini-peritoneal equilibration test: A simple and fast method to assess free water and small solute transport across the peritoneal membrane. Loss of ultrafiltration (UF) of peritoneal membrane is one of the most important causes of peritoneal dialysis failure. UF is determined by osmotic forces acti...
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| Veröffentlicht in: | Kidney international 2005-08, Vol.68 (2), p.840-846 |
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| creator | La Milia, Vincenzo Di Filippo, Salvatore Crepaldi, Monica Del Vecchio, Lucia Dell'Oro, Cesare Andrulli, Simeone Locatelli, Francesco |
| description | Mini-peritoneal equilibration test: A simple and fast method to assess free water and small solute transport across the peritoneal membrane.
Loss of ultrafiltration (UF) of peritoneal membrane is one of the most important causes of peritoneal dialysis failure. UF is determined by osmotic forces acting mainly across small pores (UFSP) and ultrasmall pores or free water transport. At present, only semiquantitative estimates or complicated computer simulations are available to assess free water transport. The aim of this study was to assess free water transport during a 3.86% peritoneal equilibration test lasting 1 hour. In this condition, sodium transport is mainly due to convection, allowing the estimate of ultrafiltration of small pores and then of free water transport (total UF - UFSP).
In 52 peritoneal dialysis patients we performed a 3.86% peritoneal equilibration test (4 hours) and a 3.86% mini-peritoneal equilibration test (1 hour) and compared UF and small solute transports obtained with the two methods.
During the 3.86% mini-peritoneal equilibration test, UFSP and free water transport were 279 ± 142mL and 215 ± 86mL , respectively; free water transport well correlated to total UF during the 3.86% peritoneal equilibration test (r = 0.67). The groups of peritoneal transporters, categorized according to glucose dialysate ratio (D/D0) and to creatinine/plasma ratio (D/PCreat), were in good agreement for the two peritoneal equilibration tests (weighted κ 0.62 and 0.61, respectively).
The 3.86% mini-peritoneal equilibration test is a simple and fast method to assess free water transport. It also gives information about total UF and small solute transports and it is in good agreement with the 3.86% peritoneal equilibration test. |
| doi_str_mv | 10.1111/j.1523-1755.2005.00465.x |
| format | Article |
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Loss of ultrafiltration (UF) of peritoneal membrane is one of the most important causes of peritoneal dialysis failure. UF is determined by osmotic forces acting mainly across small pores (UFSP) and ultrasmall pores or free water transport. At present, only semiquantitative estimates or complicated computer simulations are available to assess free water transport. The aim of this study was to assess free water transport during a 3.86% peritoneal equilibration test lasting 1 hour. In this condition, sodium transport is mainly due to convection, allowing the estimate of ultrafiltration of small pores and then of free water transport (total UF - UFSP).
In 52 peritoneal dialysis patients we performed a 3.86% peritoneal equilibration test (4 hours) and a 3.86% mini-peritoneal equilibration test (1 hour) and compared UF and small solute transports obtained with the two methods.
During the 3.86% mini-peritoneal equilibration test, UFSP and free water transport were 279 ± 142mL and 215 ± 86mL , respectively; free water transport well correlated to total UF during the 3.86% peritoneal equilibration test (r = 0.67). The groups of peritoneal transporters, categorized according to glucose dialysate ratio (D/D0) and to creatinine/plasma ratio (D/PCreat), were in good agreement for the two peritoneal equilibration tests (weighted κ 0.62 and 0.61, respectively).
The 3.86% mini-peritoneal equilibration test is a simple and fast method to assess free water transport. It also gives information about total UF and small solute transports and it is in good agreement with the 3.86% peritoneal equilibration test.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1111/j.1523-1755.2005.00465.x</identifier><identifier>PMID: 16014064</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; aquaporin ; Biological and medical sciences ; Dialysis Solutions - pharmacokinetics ; Emergency and intensive care: renal failure. Dialysis management ; Female ; free water transport ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - diagnosis ; Kidney Failure, Chronic - metabolism ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; Models, Biological ; Nephrology. Urinary tract diseases ; Osmotic Pressure ; Peritoneal Dialysis ; peritoneal equilibration test ; peritoneal transport ; Peritoneum - metabolism ; Water - metabolism</subject><ispartof>Kidney international, 2005-08, Vol.68 (2), p.840-846</ispartof><rights>2005 International Society of Nephrology</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-87d86e95c97e963ac663187a726d975e941373ce058203cd29c2265cd09f5d5e3</citedby><cites>FETCH-LOGICAL-c479t-87d86e95c97e963ac663187a726d975e941373ce058203cd29c2265cd09f5d5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210118118?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,64361,64363,64365,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17008627$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16014064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>La Milia, Vincenzo</creatorcontrib><creatorcontrib>Di Filippo, Salvatore</creatorcontrib><creatorcontrib>Crepaldi, Monica</creatorcontrib><creatorcontrib>Del Vecchio, Lucia</creatorcontrib><creatorcontrib>Dell'Oro, Cesare</creatorcontrib><creatorcontrib>Andrulli, Simeone</creatorcontrib><creatorcontrib>Locatelli, Francesco</creatorcontrib><title>Mini-peritoneal equilibration test: A simple and fast method to assess free water and small solute transport across the peritoneal membrane</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Mini-peritoneal equilibration test: A simple and fast method to assess free water and small solute transport across the peritoneal membrane.
Loss of ultrafiltration (UF) of peritoneal membrane is one of the most important causes of peritoneal dialysis failure. UF is determined by osmotic forces acting mainly across small pores (UFSP) and ultrasmall pores or free water transport. At present, only semiquantitative estimates or complicated computer simulations are available to assess free water transport. The aim of this study was to assess free water transport during a 3.86% peritoneal equilibration test lasting 1 hour. In this condition, sodium transport is mainly due to convection, allowing the estimate of ultrafiltration of small pores and then of free water transport (total UF - UFSP).
In 52 peritoneal dialysis patients we performed a 3.86% peritoneal equilibration test (4 hours) and a 3.86% mini-peritoneal equilibration test (1 hour) and compared UF and small solute transports obtained with the two methods.
During the 3.86% mini-peritoneal equilibration test, UFSP and free water transport were 279 ± 142mL and 215 ± 86mL , respectively; free water transport well correlated to total UF during the 3.86% peritoneal equilibration test (r = 0.67). The groups of peritoneal transporters, categorized according to glucose dialysate ratio (D/D0) and to creatinine/plasma ratio (D/PCreat), were in good agreement for the two peritoneal equilibration tests (weighted κ 0.62 and 0.61, respectively).
The 3.86% mini-peritoneal equilibration test is a simple and fast method to assess free water transport. It also gives information about total UF and small solute transports and it is in good agreement with the 3.86% peritoneal equilibration test.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>aquaporin</subject><subject>Biological and medical sciences</subject><subject>Dialysis Solutions - pharmacokinetics</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>free water transport</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - diagnosis</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Osmotic Pressure</subject><subject>Peritoneal Dialysis</subject><subject>peritoneal equilibration test</subject><subject>peritoneal transport</subject><subject>Peritoneum - metabolism</subject><subject>Water - metabolism</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkctuFSEYgInR2GP1FQwx0d2MXAaYcVcbb0mbbnRNKPyTcsIMU2C0PoMvLecSa7opISGEj__2IYQpaWld77ctFYw3VAnRMkJES0gnRXv3BG3-PTxFG0J60TDB-xP0IuctqfeBk-fohEpCOyK7Dfpz6WffLJB8iTOYgOF29cFfJ1N8nHGBXD7gM5z9tATAZnZ4NLngCcpNdLhEbHKGnPGYAPAvUyDtoTyZEHCOYS2ASzJzXmIq2NgUK1xuAP-XcoKp5pvhJXo2mpDh1fE8RT8-f_p-_rW5uPry7fzsorGdGkrTK9dLGIQdFAySGyslp70yikk3KAFDR7niFojoGeHWscEyJoV1ZBiFE8BP0btD3CXF27V2qCefLYRQa4hr1rInTAnaVfDNA3Ab1zTX2jSjhNK-7gr1B2jfW4JRL8lPJv3WlOidLb3VOyl6J0XvbOm9LX1Xv74-xl-vJ3D3H496KvD2CJhsTRjrlKzP95yqRiVTlft44KCO7aeHpLP1MFtwPoEt2kX_eDV_Aae5tEo</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>La Milia, Vincenzo</creator><creator>Di Filippo, Salvatore</creator><creator>Crepaldi, Monica</creator><creator>Del Vecchio, Lucia</creator><creator>Dell'Oro, Cesare</creator><creator>Andrulli, Simeone</creator><creator>Locatelli, Francesco</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Mini-peritoneal equilibration test: A simple and fast method to assess free water and small solute transport across the peritoneal membrane</title><author>La Milia, Vincenzo ; Di Filippo, Salvatore ; Crepaldi, Monica ; Del Vecchio, Lucia ; Dell'Oro, Cesare ; Andrulli, Simeone ; Locatelli, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-87d86e95c97e963ac663187a726d975e941373ce058203cd29c2265cd09f5d5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>aquaporin</topic><topic>Biological and medical sciences</topic><topic>Dialysis Solutions - pharmacokinetics</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>free water transport</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - diagnosis</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Nephrology. 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Loss of ultrafiltration (UF) of peritoneal membrane is one of the most important causes of peritoneal dialysis failure. UF is determined by osmotic forces acting mainly across small pores (UFSP) and ultrasmall pores or free water transport. At present, only semiquantitative estimates or complicated computer simulations are available to assess free water transport. The aim of this study was to assess free water transport during a 3.86% peritoneal equilibration test lasting 1 hour. In this condition, sodium transport is mainly due to convection, allowing the estimate of ultrafiltration of small pores and then of free water transport (total UF - UFSP).
In 52 peritoneal dialysis patients we performed a 3.86% peritoneal equilibration test (4 hours) and a 3.86% mini-peritoneal equilibration test (1 hour) and compared UF and small solute transports obtained with the two methods.
During the 3.86% mini-peritoneal equilibration test, UFSP and free water transport were 279 ± 142mL and 215 ± 86mL , respectively; free water transport well correlated to total UF during the 3.86% peritoneal equilibration test (r = 0.67). The groups of peritoneal transporters, categorized according to glucose dialysate ratio (D/D0) and to creatinine/plasma ratio (D/PCreat), were in good agreement for the two peritoneal equilibration tests (weighted κ 0.62 and 0.61, respectively).
The 3.86% mini-peritoneal equilibration test is a simple and fast method to assess free water transport. It also gives information about total UF and small solute transports and it is in good agreement with the 3.86% peritoneal equilibration test.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16014064</pmid><doi>10.1111/j.1523-1755.2005.00465.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy aquaporin Biological and medical sciences Dialysis Solutions - pharmacokinetics Emergency and intensive care: renal failure. Dialysis management Female free water transport Humans Intensive care medicine Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Models, Biological Nephrology. Urinary tract diseases Osmotic Pressure Peritoneal Dialysis peritoneal equilibration test peritoneal transport Peritoneum - metabolism Water - metabolism |
| title | Mini-peritoneal equilibration test: A simple and fast method to assess free water and small solute transport across the peritoneal membrane |
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