Thrombin generation and phenotypic correlation in haemophilia A

The clinical phenotype of patients with haemophilia A (HA) often differs between individuals with the same factor VIII (FVIII) gene defect (e.g. within the same family) or the same coagulant activity of FVIII (FVIII:C). We proposed that because the thrombin generation assay in platelet‐poor plasma o...

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Veröffentlicht in:	Haemophilia : the official journal of the World Federation of Hemophilia 2005-07, Vol.11 (4), p.326-334
Hauptverfasser:	Beltrán-Miranda, C. P., Khan, A., Jaloma-Cruz, A. R., Laffan, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation - physiology endogenous thrombin potential Factor V - genetics Factor VIII - analysis Factor VIII - physiology factor VIII coagulant activity Family Health FVIII-deficient plasma haemophilia A Hemophilia A - genetics Hemophilia A - physiopathology Humans Phenotype platelet-poor plasma Polymorphism, Genetic - genetics Prothrombin - genetics Severity of Illness Index Thrombin - physiology thrombin generation assay Thromboplastin - genetics
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